Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw4104 |
STRUCTURAL BIOLOGY Structural basis for eIF2B inhibition in integrated stress response | |
Kashiwagi, Kazuhiro; Yokoyama, Takeshi; Nishimoto, Madoka; Takahashi, Mari; Sakamoto, Ayako; Yonemochi, Mayumi; Shirouzu, Mikako; Ito, Takuhiro | |
2019-05-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:495-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | A core event in the integrated stress response, an adaptive pathway common to all eukaryotic cells in response to various stress stimuli, is the phosphorylation of eukaryotic translation initiation factor 2 (eIF2). Normally, unphosphorylated eIF2 transfers the methionylated initiator tRNA to the ribosome in a guanosine 5'-triphosphate-dependent manner. By contrast, phosphorylated eIF2 inhibits its specific guanine nucleotide exchange factor, eIF2B. To elucidate how the eIF2 phosphorylation status regulates the eIF2B activity, we determined cryo-electron microscopic and crystallographic structures of eIF2B in complex with unphosphorylated or phosphorylated eIF2. The unphosphorylated and phosphorylated forms of eIF2 bind to eIF2B in completely different manners: the nucleotide exchange-active and -inactive modes, respectively. These structures explain how phosphorylated eIF2 dominantly inhibits the nucleotide exchange activity of eIF2B. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600036 |
WOS关键词 | NUCLEOTIDE-EXCHANGE FACTOR ; FACTOR 2B EIF2B ; CRYSTAL-STRUCTURE ; INITIATION-FACTOR-2 EIF2-ALPHA ; TRANSLATIONAL REGULATION ; CATALYTIC DOMAIN ; EPSILON-SUBUNIT ; ALPHA-SUBUNIT ; REVEALS ; BINDING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201345 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | RIKEN Ctr Biosyst Dynam Res, Tsurumi Ku, Suehiro Cho, Yokohama, Kanagawa 2300045, Japan |
推荐引用方式 GB/T 7714 | Kashiwagi, Kazuhiro,Yokoyama, Takeshi,Nishimoto, Madoka,et al. STRUCTURAL BIOLOGY Structural basis for eIF2B inhibition in integrated stress response[J]. SCIENCE,2019,364(6439):495-+. |
APA | Kashiwagi, Kazuhiro.,Yokoyama, Takeshi.,Nishimoto, Madoka.,Takahashi, Mari.,Sakamoto, Ayako.,...&Ito, Takuhiro.(2019).STRUCTURAL BIOLOGY Structural basis for eIF2B inhibition in integrated stress response.SCIENCE,364(6439),495-+. |
MLA | Kashiwagi, Kazuhiro,et al."STRUCTURAL BIOLOGY Structural basis for eIF2B inhibition in integrated stress response".SCIENCE 364.6439(2019):495-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论