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Using a newly introduced framework to measure ecological stressor interactions 期刊论文
ECOLOGY LETTERS, 2020
作者:  Tekin, Elif;  Diamant, Eleanor S.;  Cruz-Loya, Mauricio;  Enriquez, Vivien;  Singh, Nina;  Savage, Van M.;  Yeh, Pamela J.
收藏  |  浏览/下载：7/0  |  提交时间：2020/07/06
Antagonism  antibiotics  food webs  multiple stressors  synergy  
Measuring Coevolutionary Dynamics in Species-Rich Communities 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2020, 35 (6) : 539-550
作者:  Hall, Alex R.;  Ashby, Ben;  Bascompte, Jordi;  King, Kayla C.
收藏  |  浏览/下载：5/0  |  提交时间：2020/05/13
Antagonistic cooperativity between crystal growth modifiers 期刊论文
NATURE, 2020, 577 (7791) : 497-+
作者:  Ma, Wenchuan;  Lutsko, James F.;  Rimer, Jeffrey D.;  Vekilov, Peter G.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/03

Inhibitor pairs that suppress the crystallization of haematin, which is a part of malaria parasites'  physiology, show unexpected antagonism due to attenuation of step pinning by kink blockers.


Ubiquitous processes in nature and the industry exploit crystallization from multicomponent environments(1-5)  however, laboratory efforts have focused on the crystallization of pure solutes(6,7) and the effects of single growth modifiers(8,9). Here we examine the molecular mechanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11). We use a combination of scanning probe microscopy and molecular modelling to demonstrate that inhibitor pairs, whose constituents adopt distinct mechanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor combination and applied concentrations. Synergism between two crystal growth modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not reflected in current crystal growth models. We demonstrate that kink blockers reduce the line tension of step edges, which facilitates both the nucleation of crystal layers and step propagation through the gates created by step pinners. The molecular viewpoint on cooperativity between crystallization modifiers provides guidance on the pairing of modifiers in the synthesis of crystalline materials. The proposed mechanisms indicate strategies to understand and control crystallization in both natural and engineered systems, which occurs in complex multicomponent media(1-3,8,9). In a broader context, our results highlight the complexity of crystal-modifier interactions mediated by the structure and dynamics of the crystal interface.


  
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion 期刊论文
SCIENCE, 2019, 366 (6468) : 1013-+
作者:  Leone, Robert D.;  Zhao, Liang;  Englert, Judson M.;  Sun, Im-Meng;  Oh, Min-Hee;  Sun, Im-Hong;  Arwood, Matthew L.;  Bettencourt, Ian A.;  Patel, Chirag H.;  Wen, Jiayu;  Tam, Ada;  Blosser, Richard L.;  Prchalova, Eva;  Alt, Jesse;  Rais, Rana;  Slusher, Barbara S.;  Powell, Jonathan D.
收藏  |  浏览/下载：13/0  |  提交时间：2020/02/17
Stochastic antagonism between two proteins governs a bacterial cell fate switch 期刊论文
SCIENCE, 2019, 366 (6461) : 116-+
作者:  Lord, Nathan D.;  Norman, Thomas M.;  Yuan, Ruoshi;  Bakshi, Somenath;  Losick, Richard;  Paulsson, Johan
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Wilson, Mike R.;  Reske, Jake J.;  Holladay, Jeanne;  Wilber, Genna E.;  Rhodes, Mary;  Koeman, Julie;  Adams, Marie;  Johnson, Ben;  Su, Ren-Wei;  Joshi, Niraj R.;  Patterson, Amanda L.;  Shen, Hui;  Leach, Richard E.;  Teixeira, Jose M.;  Fazleabas, Asgerally T.;  Chandler, Ronald L.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Interactions between wind and fire disturbance in forests: Competing amplifying and buffering effects 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 436: 117-128
作者:  Cannon, Jeffery B.;  Henderson, Suzanne K.;  Bailey, Michael H.;  Peterson, Chris J.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Amplifying effects  Antagonism  Buffering effects  Disturbance interactions  Prescribed fire  Synergism  Tornado  Wind damage  
Reply to 'Antipsychotics with similar association kinetics at dopamine D-2 receptors differ in extrapyramidal side-effects' 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Sykes, David A.;  Lane, J. Robert;  Szabo, Monika;  Capuano, Ben;  Javitch, Jonathan A.;  Charlton, Steven J.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Facilitation promotes invasions in plant-associated microbial communities 期刊论文
ECOLOGY LETTERS, 2019, 22 (1) : 149-158
作者:  Li, Mei;  Wei, Zhong;  Wang, Jianing;  Jousset, Alexandre;  Friman, Ville-Petri;  Xu, Yangchun;  Shen, Qirong;  Pommier, Thomas
收藏  |  浏览/下载：17/0  |  提交时间：2019/04/09
Antagonism  community ecology  facilitation  invasion resistance  microbe-microbe-plant interactions  rhizosphere  
Bacterial antagonism in host-associated microbial communities 期刊论文
SCIENCE, 2018, 361 (6408)
作者:  Garcia-Bayona, Leonor;  Comstock, Laurie E.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27