Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav2588 |
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion | |
Leone, Robert D.1; Zhao, Liang1; Englert, Judson M.1; Sun, Im-Meng1; Oh, Min-Hee1; Sun, Im-Hong1; Arwood, Matthew L.1; Bettencourt, Ian A.1; Patel, Chirag H.1; Wen, Jiayu1; Tam, Ada1; Blosser, Richard L.1; Prchalova, Eva2; Alt, Jesse2; Rais, Rana2; Slusher, Barbara S.2; Powell, Jonathan D.1 | |
2019-11-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6468页码:1013-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment of tumors. We demonstrate that glutamine blockade in tumor-bearing mice suppresses oxidative and glycolytic metabolism of cancer cells, leading to decreased hypoxia, acidosis, and nutrient depletion. By contrast, effector T cells responded to glutamine antagonism by markedly up-regulating oxidative metabolism and adopting a long-lived, highly activated phenotype. These divergent changes in cellular metabolism and programming form the basis for potent antitumor responses. Glutamine antagonism therefore exposes a previously undefined difference in metabolic plasticity between cancer cells and effector T cells that can be exploited as a "metabolic checkpoint" for tumor immunotherapy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000498849000045 |
WOS关键词 | PYRUVATE-CARBOXYLASE ; PHASE-II ; 6-DIAZO-5-OXO-L-NORLEUCINE DON ; T-CELLS ; CANCER ; MYC ; INHIBITION ; REGULATOR ; DELIVERY ; PRODRUG |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226249 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Johns Hopkins, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD 21287 USA; 2.Johns Hopkins Sch Med, Johns Hopkins Drug Discovery, Baltimore, MD 21205 USA |
推荐引用方式 GB/T 7714 | Leone, Robert D.,Zhao, Liang,Englert, Judson M.,et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion[J]. SCIENCE,2019,366(6468):1013-+. |
APA | Leone, Robert D..,Zhao, Liang.,Englert, Judson M..,Sun, Im-Meng.,Oh, Min-Hee.,...&Powell, Jonathan D..(2019).Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.SCIENCE,366(6468),1013-+. |
MLA | Leone, Robert D.,et al."Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion".SCIENCE 366.6468(2019):1013-+. |
条目包含的文件 | 条目无相关文件。 |
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