DOI | 10.1038/s41586-019-1918-4
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| Antagonistic cooperativity between crystal growth modifiers |
| Ma, Wenchuan1; Lutsko, James F.2; Rimer, Jeffrey D.1,3; Vekilov, Peter G.1,3
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| 2020-01-02
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发表期刊 | NATURE
![](/C666/image/waiting.gif) |
ISSN | 0028-0836
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EISSN | 1476-4687
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出版年 | 2020
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卷号 | 577期号:7791页码:497-+ |
文章类型 | Article
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语种 | 英语
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国家 | USA; Belgium |
英文关键词 | Inhibitor pairs that suppress the crystallization of haematin, which is a part of malaria parasites'
physiology, show unexpected antagonism due to attenuation of step pinning by kink blockers.
Ubiquitous processes in nature and the industry exploit crystallization from multicomponent environments(1-5)
however, laboratory efforts have focused on the crystallization of pure solutes(6,7) and the effects of single growth modifiers(8,9). Here we examine the molecular mechanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11). We use a combination of scanning probe microscopy and molecular modelling to demonstrate that inhibitor pairs, whose constituents adopt distinct mechanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor combination and applied concentrations. Synergism between two crystal growth modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not reflected in current crystal growth models. We demonstrate that kink blockers reduce the line tension of step edges, which facilitates both the nucleation of crystal layers and step propagation through the gates created by step pinners. The molecular viewpoint on cooperativity between crystallization modifiers provides guidance on the pairing of modifiers in the synthesis of crystalline materials. The proposed mechanisms indicate strategies to understand and control crystallization in both natural and engineered systems, which occurs in complex multicomponent media(1-3,8,9). In a broader context, our results highlight the complexity of crystal-modifier interactions mediated by the structure and dynamics of the crystal interface.
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领域 | 地球科学
; 气候变化
; 资源环境
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收录类别 | SCI-E
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WOS记录号 | WOS:000509200100012
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WOS关键词 | HEMATIN CRYSTALLIZATION
; MOLECULAR-MECHANISMS
; QUINOLINE ANTIMALARIALS
; MORPHOLOGIES
; KINETICS
; DESIGN
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WOS类目 | Multidisciplinary Sciences
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WOS研究方向 | Science & Technology - Other Topics
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引用统计 |
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文献类型 | 期刊论文
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条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281411
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专题 | 地球科学 资源环境科学 气候变化
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作者单位 | 1.Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77004 USA; 2.Univ Libre Bruxelles, Ctr Nonlinear Phenomena & Complex Syst, Brussels, Belgium; 3.Univ Houston, Dept Chem, Houston, TX 77004 USA
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推荐引用方式 GB/T 7714 |
Ma, Wenchuan,Lutsko, James F.,Rimer, Jeffrey D.,et al. Antagonistic cooperativity between crystal growth modifiers[J].
NATURE,2020,577(7791):497-+.
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APA |
Ma, Wenchuan,Lutsko, James F.,Rimer, Jeffrey D.,&Vekilov, Peter G..(2020).Antagonistic cooperativity between crystal growth modifiers.NATURE,577(7791),497-+.
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MLA |
Ma, Wenchuan,et al."Antagonistic cooperativity between crystal growth modifiers".NATURE 577.7791(2020):497-+.
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