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A noncoding RNA modulator potentiates phenylalanine metabolism in mice 期刊论文
Science, 2021
作者:  Yajuan Li;  Zhi Tan;  Yaohua Zhang;  Zhao Zhang;  Qingsong Hu;  Ke Liang;  Yao Jun;  Youqiong Ye;  Yi-Chuan Li;  Chunlai Li;  Lan Liao;  Jianming Xu;  Zhen Xing;  Yinghong Pan;  Sujash S. Chatterjee;  Tina K. Nguyen;  Heidi Hsiao;  Sergey D. Egranov;  Nagireddy Putluri;  Cristian Coarfa;  David H. Hawke;  Preethi H. Gunaratne;  Kuang-Lei Tsai;  Leng Han;  Mien-Chie Hung;  George A. Calin;  Fares Namour;  Jean-Louis Guéant;  Ania C. Muntau;  Nenad Blau;  V. Reid Sutton;  Manuel Schiff;  François Feillet;  Shuxing Zhang;  Chunru Lin;  Liuqing Yang
收藏  |  浏览/下载:16/0  |  提交时间:2021/08/10
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
Echolocation in soft-furred tree mice 期刊论文
Science, 2021
作者:  Kai He;  Qi Liu;  Dong-Ming Xu;  Fei-Yan Qi;  Jing Bai;  Shui-Wang He;  Peng Chen;  Xin Zhou;  Wan-Zhi Cai;  Zhong-Zheng Chen;  Zhen Liu;  Xue-Long Jiang;  Peng Shi
收藏  |  浏览/下载:11/0  |  提交时间:2021/06/24
Reversible fusion and fission of graphene oxide–based fibers 期刊论文
Science, 2021
作者:  Dan Chang;  Jingran Liu;  Bo Fang;  Zhen Xu;  Zheng Li;  Yilun Liu;  Laurence Brassart;  Fan Guo;  Weiwei Gao;  Chao Gao
收藏  |  浏览/下载:18/0  |  提交时间:2021/05/14
Reviewing global estimates of surface reactive nitrogen concentration and deposition using satellite retrievals 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Lei Liu, Xiuying Zhang, Wen Xu, Xuejun Liu, Xuehe Lu, Jing Wei, Yi Li, Yuyu Yang, Zhen Wang, and Anthony Y. H. Wong
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/09
Substrate regulation leads to differential responses of microbial ammonia-oxidizing communities to ocean warming 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Zheng, Zhen-Zhen;  Zheng, Li-Wei;  Xu, Min Nina;  Tan, Ehui;  Hutchins, David A.;  Deng, Wenchao;  Zhang, Yao;  Shi, Dalin;  Dai, Minhan;  Kao, Shuh-Ji
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/21
Inverse modeling of SO2 and NOx emissions over China using multisensor satellite data - Part 1: Formulation and sensitivity analysis 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 6631-6650
作者:  Wang, Yi;  Wang, Jun;  Xu, Xiaoguang;  Henze, Daven K.;  Qu, Zhen;  Yang, Kai
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Large loss of CO2 in winter observed across the northern permafrost region 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (11) : 852-+
作者:  Natali, Susan M.;  Watts, Jennifer D.;  Rogers, Brendan M.;  Potter, Stefano;  Ludwig, Sarah M.;  Selbmann, Anne-Katrin;  Sullivan, Patrick F.;  Abbott, Benjamin W.;  Arndt, Kyle A.;  Birch, Leah;  Bjorkman, Mats P.;  Bloom, A. Anthony;  Celis, Gerardo;  Christensen, Torben R.;  Christiansen, Casper T.;  Commane, Roisin;  Cooper, Elisabeth J.;  Crill, Patrick;  Czimczik, Claudia;  Davydov, Sergey;  Du, Jinyang;  Egan, Jocelyn E.;  Elberling, Bo;  Euskirchen, Eugenie S.;  Friborg, Thomas;  Genet, Helene;  Goeckede, Mathias;  Goodrich, Jordan P.;  Grogan, Paul;  Helbig, Manuel;  Jafarov, Elchin E.;  Jastrow, Julie D.;  Kalhori, Aram A. M.;  Kim, Yongwon;  Kimball, John S.;  Kutzbach, Lars;  Lara, Mark J.;  Larsen, Klaus S.;  Lee, Bang-Yong;  Liu, Zhihua;  Loranty, Michael M.;  Lund, Magnus;  Lupascu, Massimo;  Madani, Nima;  Malhotra, Avni;  Matamala, Roser;  McFarland, Jack;  McGuire, A. David;  Michelsen, Anders;  Minions, Christina;  Oechel, Walter C.;  Olefeldt, David;  Parmentier, Frans-Jan W.;  Pirk, Norbert;  Poulter, Ben;  Quinton, William;  Rezanezhad, Fereidoun;  Risk, David;  Sachs, Torsten;  Schaefer, Kevin;  Schmidt, Niels M.;  Schuur, Edward A. G.;  Semenchuk, Philipp R.;  Shaver, Gaius;  Sonnentag, Oliver;  Starr, Gregory;  Treat, Claire C.;  Waldrop, Mark P.;  Wang, Yihui;  Welker, Jeffrey;  Wille, Christian;  Xu, Xiaofeng;  Zhang, Zhen;  Zhuang, Qianlai;  Zona, Donatella
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27