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The animal origin of SARS-CoV-2 期刊论文
Science, 2021
作者:  Spyros Lytras;  Wei Xia;  Joseph Hughes;  Xiaowei Jiang;  David L. Robertson
收藏  |  浏览/下载:24/0  |  提交时间:2021/08/30
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
A small climate-amplifying effect of climate-carbon cycle feedback 期刊论文
Nature Communications, 2021
作者:  Xuanze Zhang;  Ying-Ping Wang;  Peter J. Rayner;  Philippe Ciais;  Kun Huang;  Yiqi Luo;  Shilong Piao;  Zhonglei Wang;  Jianyang Xia;  Wei Zhao;  Xiaogu Zheng;  Jing Tian;  Yongqiang Zhang
收藏  |  浏览/下载:14/0  |  提交时间:2021/06/07
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity 期刊论文
Science, 2021
作者:  Wei Hui;  Lingfeng Chao;  Hui Lu;  Fei Xia;  Qi Wei;  Zhenhuang Su;  Tingting Niu;  Lei Tao;  Bin Du;  Deli Li;  Yue Wang;  He Dong;  Shouwei Zuo;  Bixin Li;  Wei Shi;  Xueqin Ran;  Ping Li;  Hui Zhang;  Zhongbin Wu;  Chenxin Ran;  Lin Song;  Guichuan Xing;  Xingyu Gao;  Jing Zhang;  Yingdong Xia;  Yonghua Chen;  Wei Huang
收藏  |  浏览/下载:21/0  |  提交时间:2021/04/06
Long‐term, amplified responses of soil organic carbon to nitrogen addition worldwide 期刊论文
Global Change Biology, 2021
作者:  Chonghua Xu;  Xia Xu;  Chenghui Ju;  Han Y. H. Chen;  Brian J. Wilsey;  Yiqi Luo;  Wei Fan
收藏  |  浏览/下载:12/0  |  提交时间:2021/01/22
Surface brightening in eastern and central China since the implementation of the Clean Air Action in 2013: causes and implications 期刊论文
Geophysical Research Letters, 2020
作者:  Hongrong Shi;  Jinqiang Zhang;  Bin Zhao;  Xiangao Xia;  Bo Hu;  Hongbin Chen;  Jing Wei;  Mengqi Liu;  Yuxuan Bian;  Disong Fu;  Yu Gu;  Kuo‐;  Nan Liou
收藏  |  浏览/下载:15/0  |  提交时间:2021/01/22
Significant production of ClNO2 and possible source of Cl-2 from N2O5 uptake at a suburban site in eastern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 6147-6158
作者:  Xia, Men;  Peng, Xiang;  Wang, Weihao;  Yu, Chuan;  Sun, Peng;  Li, Yuanyuan;  Liu, Yuliang;  Xu, Zhengning;  Wang, Zhe;  Xu, Zheng;  Nie, Wei;  Ding, Aijun;  Wang, Tao
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/01
Importance of Resolving Mesoscale Eddies in the Model Simulation of Ningaloo Niño 期刊论文
Geophysical Research Letters, 2020
作者:  Yaru Guo;  Yuanlong Li;  Fan Wang;  Yuntao Wei;  Qiong Xia
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/25
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
CRISPR screen in regulatory T cells reveals modulators of Foxp3 期刊论文
NATURE, 2020
作者:  Xu, Daqian;  Wang, Zheng;  Xia, Yan;  Shao, Fei;  Xia, Weiya;  Wei, Yongkun;  Li, Xinjian;  Qian, Xu;  Lee, Jong-Ho;  Du, Linyong;  Zheng, Yanhua;  Lv, Guishuai;  Leu, Jia-shiun;  Wang, Hongyang;  Xing, Dongming;  Liang, Tingbo;  Hung, Mien-Chie;  Lu, Zhimin
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

Regulatory T (T-reg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumour immunity(1). Conversely, T-reg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties(2), can promote autoimmunity and/or facilitate more effective tumour immunity(3,4). A comprehensive understanding of the pathways that regulate Foxp3 could lead to more effective T-reg therapies for autoimmune disease and cancer. The availability of new functional genetic tools has enabled the possibility of systematic dissection of the gene regulatory programs that modulate Foxp3 expression. Here we developed a CRISPR-based pooled screening platform for phenotypes in primary mouse T-reg cells and applied this technology to perform a targeted loss-of-function screen of around 500 nuclear factors to identify gene regulatory programs that promote or disrupt Foxp3 expression. We identified several modulators of Foxp3 expression, including ubiquitin-specific peptidase 22 (Usp22) and ring finger protein 20 (Rnf20). Usp22, a member of the deubiquitination module of the SAGA chromatin-modifying complex, was revealed to be a positive regulator that stabilized Foxp3 expression  whereas the screen suggested that Rnf20, an E3 ubiquitin ligase, can serve as a negative regulator of Foxp3. T-reg-specific ablation of Usp22 in mice reduced Foxp3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunity but protected against tumour growth in multiple cancer models. Foxp3 destabilization in Usp22-deficient T-reg cells could be rescued by ablation of Rnf20, revealing a reciprocal ubiquitin switch in T-reg cells. These results reveal previously unknown modulators of Foxp3 and demonstrate a screening method that can be broadly applied to discover new targets for T-reg immunotherapies for cancer and autoimmune disease.


A CRISPR-based screening platform was used to identify previously uncharacterized genes that regulate the regulatory T cell-specific master transcription factor Foxp3, indicating that this screening method may be broadly applicable for the discovery of other genes involved in autoimmunity and immune responses to cancer.