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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 期刊论文
Science, 2021
作者:  Tia A. Tummino;  Veronica V. Rezelj;  Benoit Fischer;  Audrey Fischer;  Matthew J. O’Meara;  Blandine Monel;  Thomas Vallet;  Kris M. White;  Ziyang Zhang;  Assaf Alon;  Heiko Schadt;  Henry R. O’Donnell;  Jiankun Lyu;  Romel Rosales;  Briana L. McGovern;  Raveen Rathnasinghe;  Sonia Jangra;  Michael Schotsaert;  Jean-René Galarneau;  Nevan J. Krogan;  Laszlo Urban;  Kevan M. Shokat;  Andrew C. Kruse;  Adolfo García-Sastre;  Olivier Schwartz;  Francesca Moretti;  Marco Vignuzzi;  Francois Pognan;  Brian K. Shoichet
收藏  |  浏览/下载:24/0  |  提交时间:2021/08/10
Using DNA to reunify separated migrant families 期刊论文
Science, 2021
作者:  Elizabeth Barnert;  Sara H. Katsanis;  Ranit Mishori;  Jennifer K. Wagner;  Richard F. Selden;  Diana Madden;  Dan Berger;  Henry Erlich;  Kathryn Hampton;  Andreas Kleiser;  Alessandra La Vaccara;  Thomas J. Parsons;  Fredy A. Peccerelli;  Mariana Herrera Piñero;  Michael J. Stebbins;  Patricia Vásquez;  Curren W. Warf;  Thomas J. White;  Eric Stover;  M. Veronica Svetaz
收藏  |  浏览/下载:15/0  |  提交时间:2021/06/15
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease 期刊论文
Science, 2021
作者:  Sebastian Günther;  Patrick Y. A. Reinke;  Yaiza Fernández-García;  Julia Lieske;  Thomas J. Lane;  Helen M. Ginn;  Faisal H. M. Koua;  Christiane Ehrt;  Wiebke Ewert;  Dominik Oberthuer;  Oleksandr Yefanov;  Susanne Meier;  Kristina Lorenzen;  Boris Krichel;  Janine-Denise Kopicki;  Luca Gelisio;  Wolfgang Brehm;  Ilona Dunkel;  Brandon Seychell;  Henry Gieseler;  Brenna Norton-Baker;  Beatriz Escudero-Pérez;  Martin Domaracky;  Sofiane Saouane;  Alexandra Tolstikova;  Thomas A. White;  Anna Hänle;  Michael Groessler;  Holger Fleckenstein;  Fabian Trost;  Marina Galchenkova;  Yaroslav Gevorkov;  Chufeng Li;  Salah Awel;  Ariana Peck;  Miriam Barthelmess;  Frank Schlünzen;  P. Lourdu Xavier;  Nadine Werner;  Hina Andaleeb;  Najeeb Ullah;  Sven Falke;  Vasundara Srinivasan;  Bruno Alves França;  Martin Schwinzer;  Hévila Brognaro;  Cromarte Rogers;  Diogo Melo;  Joanna J. Zaitseva-Doyle;  Juraj Knoska;  Gisel E. Peña-Murillo;  Aida Rahmani Mashhour;  Vincent Hennicke;  Pontus Fischer;  Johanna Hakanpää;  Jan Meyer;  Philip Gribbon;  Bernhard Ellinger;  Maria Kuzikov;  Markus Wolf;  Andrea R. Beccari;  Gleb Bourenkov;  David von Stetten;  Guillaume Pompidor;  Isabel Bento;  Saravanan Panneerselvam;  Ivars Karpics;  Thomas R. Schneider;  Maria Marta Garcia-Alai;  Stephan Niebling;  Christian Günther;  Christina Schmidt;  Robin Schubert;  Huijong Han;  Juliane Boger;  Diana C. F. Monteiro;  Linlin Zhang;  Xinyuanyuan Sun;  Jonathan Pletzer-Zelgert;  Jan Wollenhaupt;  Christian G. Feiler;  Manfred S. Weiss;  Eike-Christian Schulz;  Pedram Mehrabi;  Katarina Karničar;  Aleksandra Usenik;  Jure Loboda;  Henning Tidow;  Ashwin Chari;  Rolf Hilgenfeld;  Charlotte Uetrecht;  Russell Cox;  Andrea Zaliani;  Tobias Beck;  Matthias Rarey;  Stephan Günther;  Dusan Turk;  Winfried Hinrichs;  Henry N. Chapman;  Arwen R. Pearson;  Christian Betzel;  Alke Meents
收藏  |  浏览/下载:13/0  |  提交时间:2021/05/14
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A 期刊论文
Science, 2021
作者:  Kris M. White;  Romel Rosales;  Soner Yildiz;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Sonia Jangra;  Melissa B. Uccellini;  Raveen Rathnasinghe;  Lynda Coughlan;  Carles Martinez-Romero;  Jyoti Batra;  Ajda Rojc;  Mehdi Bouhaddou;  Jacqueline M. Fabius;  Kirsten Obernier;  Marion Dejosez;  María José Guillén;  Alejandro Losada;  Pablo Avilés;  Michael Schotsaert;  Thomas Zwaka;  Marco Vignuzzi;  Kevan M. Shokat;  Nevan J. Krogan;  Adolfo García-Sastre
收藏  |  浏览/下载:12/0  |  提交时间:2021/03/02
Nanoscale localized contacts for high fill factors in polymer-passivated perovskite solar cells 期刊论文
Science, 2021
作者:  Jun Peng;  Daniel Walter;  Yuhao Ren;  Mike Tebyetekerwa;  Yiliang Wu;  The Duong;  Qiaoling Lin;  Juntao Li;  Teng Lu;  Md Arafat Mahmud;  Olivier Lee Cheong Lem;  Shenyou Zhao;  Wenzhu Liu;  Yun Liu;  Heping Shen;  Li Li;  Felipe Kremer;  Hieu T. Nguyen;  Duk-Yong Choi;  Klaus J. Weber;  Kylie R. Catchpole;  Thomas P. White
收藏  |  浏览/下载:13/0  |  提交时间:2021/01/28
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike 期刊论文
Science, 2020
作者:  Michael Schoof;  Bryan Faust;  Reuben A. Saunders;  Smriti Sangwan;  Veronica Rezelj;  Nick Hoppe;  Morgane Boone;  Christian B. Billesbølle;  Cristina Puchades;  Caleigh M. Azumaya;  Huong T. Kratochvil;  Marcell Zimanyi;  Ishan Deshpande;  Jiahao Liang;  Sasha Dickinson;  Henry C. Nguyen;  Cynthia M. Chio;  Gregory E. Merz;  Michael C. Thompson;  Devan Diwanji;  Kaitlin Schaefer;  Aditya A. Anand;  Niv Dobzinski;  Beth Shoshana Zha;  Camille R. Simoneau;  Kristoffer Leon;  Kris M. White;  Un Seng Chio;  Meghna Gupta;  Mingliang Jin;  Fei Li;  Yanxin Liu;  Kaihua Zhang;  David Bulkley;  Ming Sun;  Amber M. Smith;  Alexandrea N. Rizo;  Frank Moss;  Axel F. Brilot;  Sergei Pourmal;  Raphael Trenker;  Thomas Pospiech;  Sayan Gupta;  Benjamin Barsi-Rhyne;  Vladislav Belyy;  Andrew W. Barile-Hill;  Silke Nock;  Yuwei Liu;  Nevan J. Krogan;  Corie Y. Ralston;  Danielle L. Swaney;  Adolfo García-Sastre;  Melanie Ott;  Marco Vignuzzi;  QCRG Structural Biology Consortium4‡;  Peter Walter;  Aashish Manglik
收藏  |  浏览/下载:14/0  |  提交时间:2020/12/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:24/0  |  提交时间:2020/12/07
Understanding and managing connected extreme events 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (7) : 611-621
作者:  Raymond, Colin;  Horton, Radley M.;  Zscheischler, Jakob;  Martius, Olivia;  AghaKouchak, Amir;  Balch, Jennifer;  Bowen, Steven G.;  Camargo, Suzana J.;  Hess, Jeremy;  Kornhuber, Kai;  Oppenheimer, Michael;  Ruane, Alex C.;  Wahl, Thomas;  White, Kathleen
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/22
Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/25
Asynchronous carbon sink saturation in African and Amazonian tropical forests 期刊论文
NATURE, 2020, 579 (7797) : 80-+
作者:  Wannes Hubau;  Simon L. Lewis;  Oliver L. Phillips;  Kofi Affum-Baffoe;  Hans Beeckman;  Aida Cuní;  -Sanchez;  Armandu K. Daniels;  Corneille E. N. Ewango;  Sophie Fauset;  Jacques M. Mukinzi;  Douglas Sheil;  Bonaventure Sonké;  Martin J. P. Sullivan;  Terry C. H. Sunderland;  Hermann Taedoumg;  Sean C. Thomas;  Lee J. T. White;  Katharine A. Abernethy;  Stephen Adu-Bredu;  Christian A. Amani;  Timothy R. Baker;  Lindsay F. Banin;  Fidè;  le Baya;  Serge K. Begne;  Amy C. Bennett;  Fabrice Benedet;  Robert Bitariho;  Yannick E. Bocko;  Pascal Boeckx;  Patrick Boundja;  Roel J. W. Brienen;  Terry Brncic;  Eric Chezeaux;  George B. Chuyong;  Connie J. Clark;  Murray Collins;  James A. Comiskey;  David A. Coomes;  Greta C. Dargie;  Thales de Haulleville;  Marie Noel Djuikouo Kamdem;  Jean-Louis Doucet;  Adriane Esquivel-Muelbert;  Ted R. Feldpausch;  Alusine Fofanah;  Ernest G. Foli;  Martin Gilpin;  Emanuel Gloor;  Christelle Gonmadje;  Sylvie Gourlet-Fleury;  Jefferson S. Hall;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Mireille B. N. Hockemba;  Annette Hladik;  Suspense A. Ifo;  Kathryn J. Jeffery;  Tommaso Jucker;  Emmanuel Kasongo Yakusu;  Elizabeth Kearsley;  David Kenfack;  Alexander Koch;  Miguel E. Leal;  Aurora Levesley;  Jeremy A. Lindsell;  Janvier Lisingo;  Gabriela Lopez-Gonzalez;  Jon C. Lovett;  Jean-Remy Makana;  Yadvinder Malhi;  Andrew R. Marshall;  Jim Martin;  Emanuel H. Martin;  Faustin M. Mbayu;  Vincent P. Medjibe;  Vianet Mihindou;  Edward T. A. Mitchard;  Sam Moore;  Pantaleo K. T. Munishi;  Natacha Nssi Bengone;  Lucas Ojo;  Fidè;  le Evouna Ondo;  Kelvin S.-H. Peh;  Georgia C. Pickavance;  Axel Dalberg Poulsen;  John R. Poulsen;  Lan Qie;  Jan Reitsma;  Francesco Rovero;  Michael D. Swaine;  Joey Talbot;  James Taplin;  David M. Taylor;  Duncan W. Thomas;  Benjamin Toirambe;  John Tshibamba Mukendi;  Darlington Tuagben;  Peter M. Umunay;  Geertje M. F. van der Heijden;  Hans Verbeeck;  Jason Vleminckx;  Simon Willcock;  Hannsjö;  rg Wö;  ll;  John T. Woods;  Lise Zemagho
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13

Structurally intact tropical forests sequestered about half of the global terrestrial carbon uptake over the 1990s and early 2000s, removing about 15 per cent of anthropogenic carbon dioxide emissions(1-3). Climate-driven vegetation models typically predict that this tropical forest '  carbon sink'  will continue for decades(4,5). Here we assess trends in the carbon sink using 244 structurally intact African tropical forests spanning 11 countries, compare them with 321 published plots from Amazonia and investigate the underlying drivers of the trends. The carbon sink in live aboveground biomass in intact African tropical forests has been stable for the three decades to 2015, at 0.66 tonnes of carbon per hectare per year (95 per cent confidence interval 0.53-0.79), in contrast to the long-term decline in Amazonian forests(6). Therefore the carbon sink responses of Earth'  s two largest expanses of tropical forest have diverged. The difference is largely driven by carbon losses from tree mortality, with no detectable multi-decadal trend in Africa and a long-term increase in Amazonia. Both continents show increasing tree growth, consistent with the expected net effect of rising atmospheric carbon dioxide and air temperature(7-9). Despite the past stability of the African carbon sink, our most intensively monitored plots suggest a post-2010 increase in carbon losses, delayed compared to Amazonia, indicating asynchronous carbon sink saturation on the two continents. A statistical model including carbon dioxide, temperature, drought and forest dynamics accounts for the observed trends and indicates a long-term future decline in the African sink, whereas the Amazonian sink continues to weaken rapidly. Overall, the uptake of carbon into Earth'  s intact tropical forests peaked in the 1990s. Given that the global terrestrial carbon sink is increasing in size, independent observations indicating greater recent carbon uptake into the Northern Hemisphere landmass(10) reinforce our conclusion that the intact tropical forest carbon sink has already peaked. This saturation and ongoing decline of the tropical forest carbon sink has consequences for policies intended to stabilize Earth'  s climate.