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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling 期刊论文
Science, 2021
作者:  Evan W. Weber;  Kevin R. Parker;  Elena Sotillo;  Rachel C. Lynn;  Hima Anbunathan;  John Lattin;  Zinaida Good;  Julia A. Belk;  Bence Daniel;  Dorota Klysz;  Meena Malipatlolla;  Peng Xu;  Malek Bashti;  Sabine Heitzeneder;  Louai Labanieh;  Panayiotis Vandris;  Robbie G. Majzner;  Yanyan Qi;  Katalin Sandor;  Ling-Chun Chen;  Snehit Prabhu;  Andrew J. Gentles;  Thomas J. Wandless;  Ansuman T. Satpathy;  Howard Y. Chang;  Crystal L. Mackall
收藏  |  浏览/下载:16/0  |  提交时间:2021/04/06
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody 期刊论文
Science, 2020
作者:  Zhe Lv;  Yong-Qiang Deng;  Qing Ye;  Lei Cao;  Chun-Yun Sun;  Changfa Fan;  Weijin Huang;  Shihui Sun;  Yao Sun;  Ling Zhu;  Qi Chen;  Nan Wang;  Jianhui Nie;  Zhen Cui;  Dandan Zhu;  Neil Shaw;  Xiao-Feng Li;  Qianqian Li;  Liangzhi Xie;  Youchun Wang;  Zihe Rao;  Cheng-Feng Qin;  Xiangxi Wang
收藏  |  浏览/下载:16/0  |  提交时间:2020/09/22
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
Science, 2020
作者:  Lu Zhang;  Yao Zhao;  Yan Gao;  Lijie Wu;  Ruogu Gao;  Qi Zhang;  Yinan Wang;  Chengyao Wu;  Fangyu Wu;  Sudagar S. Gurcha;  Natacha Veerapen;  Sarah M. Batt;  Wei Zhao;  Ling Qin;  Xiuna Yang;  Manfu Wang;  Yan Zhu;  Bing Zhang;  Lijun Bi;  Xian’en Zhang;  Haitao Yang;  Luke W. Guddat;  Wenqing Xu;  Quan Wang;  Jun Li;  Gurdyal S. Besra;  Zihe Rao
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/16
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Fossil fuel combustion and biomass burning sources of global black carbon from GEOS-Chem simulation and carbon isotope measurements 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (17) : 11545-11557
作者:  Qi, Ling;  Wang, Shuxiao
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Schultz, Mark L.;  Krus, Kelsey L.;  Kaushik, Susmita;  Dang, Derek;  Chopra, Ravi;  Qi, Ling;  Shakkottai, Vikram G.;  Cuervo, Ana Maria;  Lieberman, Andrew P.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
A Eu3+-Eu2+ ion redox shuttle imparts operational durability to Pb-I perovskite solar cells 期刊论文
SCIENCE, 2019, 363 (6424) : 265-+
作者:  Wang, Ligang;  Zhou, Huanping;  Hu, Junnan;  Huang, Bolong;  Sun, Mingzi;  Dong, Bowei;  Zheng, Guanghaojie;  Huang, Yuan;  Chen, Yihua;  Li, Liang;  Xu, Ziqi;  Li, Nengxu;  Liu, Zheng;  Chen, Qi;  Sun, Ling-Dong;  Yan, Chun-Hua
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Modeling the impact of chlorine emissions from coal combustion and prescribed waste incineration on tropospheric ozone formation in China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (4) : 2709-2724
作者:  Liu, Yiming;  Fan, Qi;  Chen, Xiaoyang;  Zhao, Jun;  Ling, Zhenhao;  Hong, Yingying;  Li, Weibiao;  Chen, Xunlai;  Wang, Mingjie;  Wei, Xiaolin
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
A supramolecular lanthanide separation approach based on multivalent cooperative enhancement of metal ion selectivity 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Li, Xiao-Zhen;  Zhou, Li-Peng;  Yan, Liang-Liang;  Dong, Ya-Min;  Bai, Zhuan-Ling;  Sun, Xiao-Qi;  Juan Diwu;  Shuao Wang;  Bunzli, Jean-Claude;  Sun, Qing-Fu
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27