3D genomics across the tree of life reveals condensin II as a determinant of architecture type

doi:10.1126/science.abe2218

GSTDTAP > 气候变化

DOI	10.1126/science.abe2218
	3D genomics across the tree of life reveals condensin II as a determinant of architecture type
	Claire Hoencamp; Olga Dudchenko; Ahmed M. O. Elbatsh; Sumitabha Brahmachari; Jonne A. Raaijmakers; Tom van Schaik; Ángela Sedeño Cacciatore; Vinícius G. Contessoto; Roy G. H. P. van Heesbeen; Bram van den Broek; Aditya N. Mhaskar; Hans Teunissen; Brian Glenn St Hilaire; David Weisz; Arina D. Omer; Melanie Pham; Zane Colaric; Zhenzhen Yang; Suhas S. P. Rao; Namita Mitra; Christopher Lui; Weijie Yao; Ruqayya Khan; Leonid L. Moroz; Andrea Kohn; Judy St. Leger; Alexandria Mena; Karen Holcroft; Maria Cristina Gambetta; Fabian Lim; Emma Farley; Nils Stein; Alexander Haddad; Daniel Chauss; Ayse Sena Mutlu; Meng C. Wang; Neil D. Young; Evin Hildebrandt; Hans H. Cheng; Christopher J. Knight; Theresa L. U. Burnham; Kevin A. Hovel; Andrew J. Beel; Pierre-Jean Mattei; Roger D. Kornberg; Wesley C. Warren; Gregory Cary; José Luis Gómez-Skarmeta; Veronica Hinman; Kerstin Lindblad-Toh; Federica Di Palma; Kazuhiro Maeshima; Asha S. Multani; Sen Pathak; Liesl Nel-Themaat; Richard R. Behringer; Parwinder Kaur; René H. Medema; Bas van Steensel; Elzo de Wit; José N. Onuchic; Michele Di Pierro; Erez Lieberman Aiden; Benjamin D. Rowland
	2021-05-28
发表期刊	Science
出版年	2021
英文摘要	The conformation of chromosomes within the nucleus can reflect a cell's type or state. However, studies of the conservation and evolutionary history of the mechanisms regulating genome structure across species are lacking. Hoencamp et al. mapped three-dimensional (3D) genome organization in 24 eukaryote species, including animals, fungi, and plants. At interphase, species' telomeres and centromeres either clustered across chromosomes or oriented in a polarized state maintaining individual chromosomal territories within the cell, a difference attributed to condensin II. An experimental loss of condensin II in human cells promotes the formation of centromere clusters but has no effect on loop or compartment formation. Whether the structure of the 3D genome varies across species may thus depend on whether they carry a functional condensin II gene. Science , abe2218, this issue p. [984][1] We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes. [1]: /lookup/doi/10.1126/science.abe2218
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/328872
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Claire Hoencamp,Olga Dudchenko,Ahmed M. O. Elbatsh,et al. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type[J]. Science,2021.
APA	Claire Hoencamp.,Olga Dudchenko.,Ahmed M. O. Elbatsh.,Sumitabha Brahmachari.,Jonne A. Raaijmakers.,...&Benjamin D. Rowland.(2021).3D genomics across the tree of life reveals condensin II as a determinant of architecture type.Science.
MLA	Claire Hoencamp,et al."3D genomics across the tree of life reveals condensin II as a determinant of architecture type".Science (2021).