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The role of terrestrial productivity and hydrology in regulating aquatic dissolved organic carbon concentrations in boreal catchments 期刊论文
Global Change Biology, 2022
作者:  Xudan Zhu;  Liang Chen;  Jukka Pumpanen;  Anne Ojala;  John Zobitz;  Xuan Zhou;  Hjalmar Laudon;  Marjo Palviainen;  Kimmo Neitola;  Frank Berninger
收藏  |  浏览/下载：11/0  |  提交时间：2022/02/23
Wintertime submesoscale offshore events overcoming wind-driven onshore currents in the East China Sea 期刊论文
Geophysical Research Letters, 2021
作者:  Jiliang Xuan;  Ruibin Ding;  Xiaobo Ni;  Daji Huang;  Jianfang Chen;  Feng Zhou
收藏  |  浏览/下载：16/0  |  提交时间：2021/11/23
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase 期刊论文
Science, 2020
作者:  Hai Zheng;  Yilun Qi;  Shibin Hu;  Xuan Cao;  Congling Xu;  Zhinang Yin;  Xizi Chen;  Yan Li;  Weida Liu;  Jie Li;  Jiawei Wang;  Gang Wei;  Kaiwei Liang;  Fei Xavier Chen;  Yanhui Xu
收藏  |  浏览/下载：10/0  |  提交时间：2020/11/30
Spatial and temporal variability of brown carbon in United States: implications for direct radiative effects 期刊论文
Geophysical Research Letters, 2020
作者:  Nicole June;  Xuan Wang;  L.‐;  W. Antony Chen;  Judith C. Chow;  John G. Watson;  Xiaoliang Wang;  Barron H. Henderson;  Yiqi Zheng;  Jingqiu Mao
收藏  |  浏览/下载：5/0  |  提交时间：2020/11/24
DNA vaccine protection against SARS-CoV-2 in rhesus macaques 期刊论文
Science, 2020
作者:  Jingyou Yu;  Lisa H. Tostanoski;  Lauren Peter;  Noe B. Mercado;  Katherine McMahan;  Shant H. Mahrokhian;  Joseph P. Nkolola;  Jinyan Liu;  Zhenfeng Li;  Abishek Chandrashekar;  David R. Martinez;  Carolin Loos;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Yuezhou Chen;  Adam Zuiani;  Felipe J. N. Lelis;  Meghan Travers;  Shaghayegh Habibi;  Laurent Pessaint;  Alex Van Ry;  Kelvin Blade;  Renita Brown;  Anthony Cook;  Brad Finneyfrock;  Alan Dodson;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Marinela Kirilova;  Nicole Kordana;  Zijin Lin;  Lori F. Maxfield;  Felix Nampanya;  Ramya Nityanandam;  John D. Ventura;  Huahua Wan;  Yongfei Cai;  Bing Chen;  Aaron G. Schmidt;  Duane R. Wesemann;  Ralph S. Baric;  Galit Alter;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载：17/0  |  提交时间：2020/08/18
Constraining remote oxidation capacity with ATom observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7753-7781
作者:  Travis, Katherine R.;  Heald, Colette L.;  Allen, Hannah M.;  Apel, Eric C.;  Arnold, Stephen R.;  Blake, Donald R.;  Brune, William H.;  Chen, Xin;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  Elkins, James W.;  Evans, Mathew J.;  Hall, Samuel R.;  Hintsa, Eric J.;  Hornbrook, Rebecca S.;  Kasibhatla, Prasad S.;  Kim, Michelle J.;  Luo, Gan;  McKain, Kathryn;  Millet, Dylan B.;  Moore, Fred L.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  Sherwen, Tomas;  Thames, Alexander B.;  Ullmann, Kirk;  Wang, Xuan;  Wennberg, Paul O.;  Wolfe, Glenn M.;  Yu, Fangqun
收藏  |  浏览/下载：48/0  |  提交时间：2020/08/18
Partitioning of hydrogen peroxide in gas-liquid and gas-aerosol phases 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5513-5526
作者:  Xuan, Xiaoning;  Chen, Zhongming;  Gong, Yiwei;  Shen, Hengqing;  Chen, Shiyi
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Insight Into Major Active Faults in Central Myanmar and the Related Geodynamic Sources 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (8)
作者:  Mon, Chit Thet;  Gong, Xuan;  Wen, Yun;  Jiang, Mingming;  Chen, Qi-Fu;  Zhang, Miao;  Hou, Guangbing;  Thant, Myo;  Sein, Kyaing;  He, Yumei
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/02
earthquake relocation  Myanmar crustal seismicity  Kabaw Fault Zone  Sagaing Fault  Central Basin  
Estimation of Secondary Organic Aerosol Formation During a Photochemical Smog Episode in Shanghai, China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (7)
作者:  Wang, Hongli;  Wang, Qian;  Gao, Yaqin;  Zhou, Min;  Jing, Shengao;  Qiao, Liping;  Yuan, Bin;  Huang, Dandan;  Huang, Cheng;  Lou, Shengrong;  Yan, Rusha;  de Gouw, Joost A.;  Zhang, Xuan;  Chen, Jianmin;  Chen, Changhong;  Tao, Shikang;  An, Jingyu;  Li, Yingjie
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
photochemistry  volatile organic compounds  secondary organic aerosols  Shanghai