Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

doi:10.1038/s41467-019-12212-7

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-019-12212-7
	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
	Wang, Yidong 1,2,3; Wu, Bingruo 1,2,3; Lu, Pengfei 1,2,3; Zhang, Donghong 1,2,3; Wu, Brian 1,2,3; Varshney, Shweta 4; del Monte-Nieto, Gonzalo 5,6; Zhuang, Zhenwu 7; Charafeddine, Rabab 8; Kramer, Adam H.8; Sibinga, Nicolas E.9,10,11; Frangogiannis, Nikolaos G.12,13; Kitsis, Richard N.14; Adams, Ralf H.15,16; Alitalo, Kari 17; Sharp, David J.8; Harvey, Richard P.5,6,18; Stanley, Pamela 4; Zhou, Bin 1,2,3,19
	2019-09-30
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	USA; Australia; Germany; Finland; Peoples R China
英文摘要	Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary artery formation remain ill-defined. Here we identify an angiogenic cell population for coronary artery formation in mice. Regulated by a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis, these angiogenic cells generate mature coronary arteries. The NOTCH modulator POFUT1 critically regulates this signaling axis. POFUT1 inactivation disrupts signaling events and results in excessive angiogenic cell proliferation and plexus formation, leading to anomalous coronary arteries, myocardial infarction and heart failure. Simultaneous VEGFR2 inactivation fully rescues these defects. These findings show that dysregulated angiogenic precursors link coronary anomalies to ischemic heart disease.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000411024900014
WOS关键词	PROTEIN O-FUCOSYL-TRANSFERASE-1 ; VENOUS SPECIFICATION ; CRE RECOMBINASE ; O-FUCOSE ; NOTCH ; VEGF ; EXPRESSION ; CELLS ; TIP ; JAGGED1
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204571
专题	资源环境科学
作者单位	1.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Genet, Bronx, NY 10461 USA; 2.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Pediat, Bronx, NY 10461 USA; 3.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Med Cardiol, Bronx, NY 10461 USA; 4.Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA; 5.Victor Chang Cardiac Res Inst, Dev & Stem Cell Biol Div, Darlinghurst, NSW 2010, Australia; 6.Univ New South Wales, St Vincents Clin Sch, Kensington, NSW 2052, Australia; 7.Yale Univ, Dept Med, New Haven, CT 06510 USA; 8.Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10461 USA; 9.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Med, Bronx, NY 10461 USA; 10.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Dev, Bronx, NY 10461 USA; 11.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Mol Biol, Bronx, NY 10461 USA; 12.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Microbiol, Bronx, NY 10461 USA; 13.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Immunol, Bronx, NY 10461 USA; 14.Albert Einstein Coll Med, Wilf Cardiovasc Res Inst, Dept Cell Biol, Bronx, NY 10461 USA; 15.Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, Rontgenstr 20, D-48149 Munster, Germany; 16.Univ Munster, Fac Med, D-48149 Munster, Germany; 17.Biomedicum Helsinki, Wihuri Res Inst, Haartmaninkatu 8, FI-00290 Helsinki, Finland; 18.Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW 2052, Australia; 19.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yidong,Wu, Bingruo,Lu, Pengfei,et al. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1[J]. NATURE COMMUNICATIONS,2019,8.
APA	Wang, Yidong.,Wu, Bingruo.,Lu, Pengfei.,Zhang, Donghong.,Wu, Brian.,...&Zhou, Bin.(2019).Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.NATURE COMMUNICATIONS,8.
MLA	Wang, Yidong,et al."Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1".NATURE COMMUNICATIONS 8(2019).