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Chesapeake Bay acidification buffered by spatially decoupled carbonate mineral cycling 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 441-+
作者:  Su, Jianzhong;  Cai, Wei-Jun;  Brodeur, Jean;  Chen, Baoshan;  Hussain, Najid;  Yao, Yichen;  Ni, Chaoying;  Testa, Jeremy M.;  Li, Ming;  Xie, Xiaohui;  Ni, Wenfei;  Scaboo, K. Michael;  Xu, Yuan-yuan;  Cornwell, Jeffrey;  Gurbisz, Cassie;  Owens, Michael S.;  Waldbusser, George G.;  Dai, Minhan;  Kemp, W. Michael
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/09
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Comprehensive Observations of Substorm-Enhanced Plasmaspheric Hiss Generation, Propagation, and Dissipation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (2)
作者:  Liu, Nigang;  Su, Zhenpeng;  Gao, Zhonglei;  Zheng, Huinan;  Wang, Yuming;  Wang, Shui;  Miyoshi, Yoshizumi;  Shinohara, Iku;  Kasahara, Yoshiya;  Tsuchiya, Fuminori;  Kumamoto, Atsushi;  Matsuda, Shoya;  Shoji, Masafumi;  Mitani, Takefumi;  Takashima, Takeshi;  Kazama, Yoichi;  Wang, Bo-Jhou;  Wang, Shiang-Yu;  Jun, Chae-Woo;  Chang, Tzu-Fang;  Tam, Sunny W. Y.;  Kasahara, Satoshi;  Yokota, Shoichiro;  Keika, Kunihiro;  Hori, Tomoaki;  Matsuoka, Ayako
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
plasmaspheric hiss  radiation belt  plasmasphere  wave generation  wave propagation  wave dissipation  
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome 期刊论文
SCIENCE, 2019, 366 (6467) : 843-+
作者:  Zhu, Ping Jun;  Khatiwada, Sanjeev;  Cui, Ya;  Reineke, Lucas C.;  Dooling, Sean W.;  Kim, Jean J.;  Li, Wei;  Walter, Peter;  Costa-Mattioli, Mauro
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
Shisa7 isa GABA(A) receptor auxiliary subunit controlling benzodiazepine actions 期刊论文
SCIENCE, 2019, 366 (6462) : 246-+
作者:  Han, Wenyan;  Li, Jun;  Pelkey, Kenneth A.;  Pandey, Saurabh;  Chen, Xiumin;  Wang, Ya-Xian;  Wu, Kunwei;  Ge, Lihao;  Li, Tianming;  Castellano, David;  Liu, Chengyu;  Wu, Ling-Gang;  Petralia, Ronald S.;  Lynch, Joseph W.;  McBain, Chris J.;  Lu, Wei
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Seconds-scale coherence on an optical clock transition in a tweezer array 期刊论文
SCIENCE, 2019, 366 (6461) : 93-+
作者:  Norcia, Matthew A.;  Young, Aaron W.;  Eckner, William J.;  Oelker, Eric;  Ye, Jun;  Kaufman, Adam M.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Device-independent quantum random-number generation 期刊论文
NATURE, 2018, 562 (7728) : 548-+
作者:  Liu, Yang;  Zhao, Qi;  Li, Ming-Han;  Guan, Jian-Yu;  Zhang, Yanbao;  Bai, Bing;  Zhang, Weijun;  Liu, Wen-Zhao;  Wu, Cheng;  Yuan, Xiao;  Li, Hao;  Munro, W. J.;  Wang, Zhen;  You, Lixing;  Zhang, Jun;  Ma, Xiongfeng;  Fan, Jingyun;  Zhang, Qiang;  Pan, Jian-Wei
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Characteristics of Satellite Sampling Errors in Total Precipitable Water from SSMIS, HIRS, and COSMIC Observations 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (13) : 6966-6981
作者:  Xue, Yunheng;  Li, Jun;  Menzel, W. Paul;  Borbas, Eva;  Ho, Shu-Peng;  Li, Zhenglong;  Li, Jinlong
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
TPW variation  remote sensing  sampling error  
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Shungin, Dmitry;  Hawort, Simon;  Divaris, Kimon;  Agler, Cary S.;  Kamatani, Yoichiro;  Lee, Myoung Keun;  Grinde, Kelsey;  Hindy, George;  Alaraudanjoki, Viivi;  Pesonen, Paula;  Teumer, Alexander;  Holtfreter, Birte;  Sakaue, Saori;  Hirata, Jun;  Yu, Yau-Hua;  Ridker, Paul M.;  Giulianini, Franco;  Chasman, Daniel, I;  Magnusson, Patrik K. E.;  Sudo, Takeaki;  Okada, Yukinori;  Voelker, Uwe;  Kocher, Thomas;  Anttonen, Vuokko;  Laitala, Marja-Liisa;  Orho-Melander, Marju;  Sofer, Tamar;  Shaffer, John R.;  Vieira, Alexandre;  Marazita, Mary L.;  Kubo, Michiaki;  Furuichi, Yasushi;  North, Kari E.;  Offenbacher, Steve;  Ingelsson, Erik;  FrankS, Paul W.;  Timpson, Nicholas J.;  Johansson, Ingegerd
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27