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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 期刊论文
Science, 2020
作者:  Thomas W. Linsky;  Renan Vergara;  Nuria Codina;  Jorgen W. Nelson;  Matthew J. Walker;  Wen Su;  Christopher O. Barnes;  Tien-Ying Hsiang;  Katharina Esser-Nobis;  Kevin Yu;  Z. Beau Reneer;  Yixuan J. Hou;  Tanu Priya;  Masaya Mitsumoto;  Avery Pong;  Uland Y. Lau;  Marsha L. Mason;  Jerry Chen;  Alex Chen;  Tania Berrocal;  Hong Peng;  Nicole S. Clairmont;  Javier Castellanos;  Yu-Ru Lin;  Anna Josephson-Day;  Ralph S. Baric;  Deborah H. Fuller;  Carl D. Walkey;  Ted M. Ross;  Ryan Swanson;  Pamela J. Bjorkman;  Michael Gale;  Luis M. Blancas-Mejia;  Hui-Ling Yen;  Daniel-Adriano Silva
收藏  |  浏览/下载:11/0  |  提交时间:2020/12/07
Centennial response of Greenland鈥檚 three largest outlet glaciers 期刊论文
Nature Communications, 2020
作者:  Shfaqat A. Khan;  Anders A. Bjø;  rk;  Jonathan L. Bamber;  Mathieu Morlighem;  Michael Bevis;  Kurt H. Kjæ;  r;  ;  ;  mie Mouginot;  Anja Lø;  kkegaard;  David M. Holland;  Andy Aschwanden;  Bao Zhang;  Veit Helm;  Niels J. Korsgaard;  William Colgan;  Nicolaj K. Larsen;  Lin Liu;  Karina Hansen;  Valentina Barletta;  Trine S. Dahl-Jensen;  Anne Sofie Sø;  ndergaard;  Beata M. Csatho;  Ingo Sasgen;  Jason Box;  Toni Schenk
收藏  |  浏览/下载:12/0  |  提交时间:2020/11/24
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes 期刊论文
Science, 2020
作者:  Ching-Lin Hsieh;  Jory A. Goldsmith;  Jeffrey M. Schaub;  Andrea M. DiVenere;  Hung-Che Kuo;  Kamyab Javanmardi;  Kevin C. Le;  Daniel Wrapp;  Alison G. Lee;  Yutong Liu;  Chia-Wei Chou;  Patrick O. Byrne;  Christy K. Hjorth;  Nicole V. Johnson;  John Ludes-Meyers;  Annalee W. Nguyen;  Juyeon Park;  Nianshuang Wang;  Dzifa Amengor;  Jason J. Lavinder;  Gregory C. Ippolito;  Jennifer A. Maynard;  Ilya J. Finkelstein;  Jason S. McLellan
收藏  |  浏览/下载:14/0  |  提交时间:2020/09/22
Expanding the space of protein geometries by computational design of de novo fold families 期刊论文
Science, 2020
作者:  Xingjie Pan;  Michael C. Thompson;  Yang Zhang;  Lin Liu;  James S. Fraser;  Mark J. S. Kelly;  Tanja Kortemme
收藏  |  浏览/下载:10/0  |  提交时间:2020/09/08
Architecture and function of human uromodulin filaments in urinary tract infections 期刊论文
Science, 2020
作者:  Gregor L. Weiss;  Jessica J. Stanisich;  Maximilian M. Sauer;  Chia-Wei Lin;  Jonathan Eras;  Dawid S. Zyla;  Johannes Trück;  Olivier Devuyst;  Markus Aebi;  Martin Pilhofer;  Rudi Glockshuber
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/25
DNA vaccine protection against SARS-CoV-2 in rhesus macaques 期刊论文
Science, 2020
作者:  Jingyou Yu;  Lisa H. Tostanoski;  Lauren Peter;  Noe B. Mercado;  Katherine McMahan;  Shant H. Mahrokhian;  Joseph P. Nkolola;  Jinyan Liu;  Zhenfeng Li;  Abishek Chandrashekar;  David R. Martinez;  Carolin Loos;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Yuezhou Chen;  Adam Zuiani;  Felipe J. N. Lelis;  Meghan Travers;  Shaghayegh Habibi;  Laurent Pessaint;  Alex Van Ry;  Kelvin Blade;  Renita Brown;  Anthony Cook;  Brad Finneyfrock;  Alan Dodson;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Marinela Kirilova;  Nicole Kordana;  Zijin Lin;  Lori F. Maxfield;  Felix Nampanya;  Ramya Nityanandam;  John D. Ventura;  Huahua Wan;  Yongfei Cai;  Bing Chen;  Aaron G. Schmidt;  Duane R. Wesemann;  Ralph S. Baric;  Galit Alter;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
收藏  |  浏览/下载:18/0  |  提交时间:2020/08/18
Broad neutralization of SARS-related viruses by human monoclonal antibodies 期刊论文
Science, 2020
作者:  Anna Z. Wec;  Daniel Wrapp;  Andrew S. Herbert;  Daniel P. Maurer;  Denise Haslwanter;  Mrunal Sakharkar;  Rohit K. Jangra;  M. Eugenia Dieterle;  Asparouh Lilov;  Deli Huang;  Longping V. Tse;  Nicole V. Johnson;  Ching-Lin Hsieh;  Nianshuang Wang;  Juergen H. Nett;  Elizabeth Champney;  Irina Burnina;  Michael Brown;  Shu Lin;  Melanie Sinclair;  Carl Johnson;  Sarat Pudi;  Robert Bortz;  Ariel S. Wirchnianski;  Ethan Laudermilch;  Catalina Florez;  J. Maximilian Fels;  Cecilia M. O’Brien;  Barney S. Graham;  David Nemazee;  Dennis R. Burton;  Ralph S. Baric;  James E. Voss;  Kartik Chandran;  John M. Dye;  Jason S. McLellan;  Laura M. Walker
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Coseismic uplift of the 1999 M w7.6 Chi‐Chi earthquake and implication to topographic change in frontal mountain belts 期刊论文
Geophysical Research Letters, 2020
作者:  R. Y. Chuang;  C. H. Lu;  C. J. Yang;  Y. S. Lin;  T. Y. Lee
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/09
Climate change considerations are fundamental to management of deep‐sea resource extraction 期刊论文
Global Change Biology, 2020
作者:  Lisa A. Levin;  Chih‐;  Lin Wei;  Daniel C. Dunn;  Diva J. Amon;  Oliver S. Ashford;  William W. L. Cheung;  Ana Colaç;  o;  Carlos Dominguez‐;  Carrió;  Elva G. Escobar;  Harriet R. Harden‐;  Davies;  Jeffrey C. Drazen;  Khaira Ismail;  Daniel O. B. Jones;  David E. Johnson;  Jennifer T. Le;  Franck Lejzerowicz;  Satoshi Mitarai;  Telmo Morato;  Sandor Mulsow;  Paul V. R. Snelgrove;  Andrew K. Sweetman;  Moriaki Yasuhara
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/09
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).