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Increase of High Molecular Weight Organosulfate With Intensifying Urban Air Pollution in the Megacity Beijing 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (10)
作者:  Xie, Qiaorong;  Li, Ying;  Yue, Siyao;  Su, Sihui;  Cao, Dong;  Xu, Yisheng;  Chen, Jing;  Tong, Haijie;  Su, Hang;  Cheng, Yafang;  Zhao, Wanyu;  Hu, Wei;  Wang, Zhe;  Yang, Ting;  Pan, Xiaole;  Sun, Yele;  Wang, Zifa;  Liu, Cong-Qiang;  Kawamura, Kimitaka;  Jiang, Guibin;  Shiraiwa, Manabu;  Fu, Pingqing
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/02
Organic aerosol  Organosulfates  FT-ICR MS  Secondary organic aerosol  Volatile organic compounds  
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
The evolutionary history of 2,658 cancers 期刊论文
NATURE, 2020, 578 (7793) : 122-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

Cancer develops through a process of somatic evolution(1,2). Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes(3). Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(4), we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.


  
A study of energy literacy among nursing students to examine implications on energy conservation efforts in Taiwan 期刊论文
ENERGY POLICY, 2019, 135
作者:  Lee, Lung-Sheng;  Lee, Yi-Fang;  Wu, Ming-Jivan;  Pan, Ying-Ju
收藏  |  浏览/下载:13/0  |  提交时间:2020/02/17
Energy literacy  Nursing education  Energy conservation behavior  Energy affect  Energy knowledge  
Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Hu, Shichen;  Guo, Yujiao;  Wang, Yingli;  Li, Ying;  Fu, Tao;  Zhou, Zixuan;  Wang, Yaru;  Liu, Jianping;  Pan, Lifeng
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Developing a two-step algorithm to estimate the leaf area index of forests with complex structures based on CHRIS/PROBA data 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 441: 57-70
作者:  Lin, Jie;  Pan, Ying;  Lyu, Heng;  Zhu, Xi;  Li, Xiao;  Dong, Bo;  Li, Haidong
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/26
The two-step method  Forest LAI  PROSAIL model  PROBA/CHRIS data  
Ezh2 phosphorylation state determines its capacity to maintain CD8(+) T memory precursors for antitumor immunity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  He, Shan;  Liu, Yongnian;  Meng, Lijun;  Sun, Hongxing;  Wang, Ying;  Ji, Yun;  Purushe, Janaki;  Chen, Pan;  Li, Changhong;  Madzo, Jozef;  Issa, Jean-Pierre;  Soboloff, Jonathan;  Reshef, Ran;  Moore, Bethany;  Gattinoni, Luca;  Zhang, Yi
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Enhanced agricultural sustainability through within-species diversification 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (1) : 46-52
作者:  Yang, Li-Na;  Pan, Zhe-Chao;  Zhu, Wen;  Wu, E-Jiao;  He, Dun-Chun;  Yuan, Xiao;  Qin, Yan-Yu;  Wang, Ying;  Chen, Ruey-Shyang;  Thrall, Peter H.;  Burdon, Jeremy J.;  Shang, Li-Ping;  Sui, Qi-Jun;  Zhan, Jiasui
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/19
Joint effects of several factors on cloud-to-ground lightning and rainfall in Nanning (China) 期刊论文
ATMOSPHERIC RESEARCH, 2018, 212: 23-32
作者:  Li, Xiong;  Pan, Ying;  Mo, Zhaoyu
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Lightning  Rainfall  Aerosol  Humidity  Joint effect  
Forecasting severe convective storms with WRF-based RTFDDA radar data assimilation in Guangdong, China 期刊论文
ATMOSPHERIC RESEARCH, 2018, 209: 131-143
作者:  Huang, Yongjie;  Liu, Yubao;  Xu, Mei;  Liu, Yuewei;  Pan, Linlin;  Wang, Haoliang;  Cheng, Will Y. Y.;  Jiang, Ying;  Lan, Hongping;  Yang, Honglong;  Wei, Xiaolin;  Zong, Rong;  Cao, Chunyan
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Severe convective storms  RTFDDA  Radar data assimilation  Latent heating  Nowcasting