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DOI | 10.1038/s41467-017-01879-5 |
Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering | |
Hu, Shichen; Guo, Yujiao; Wang, Yingli; Li, Ying; Fu, Tao; Zhou, Zixuan; Wang, Yaru; Liu, Jianping; Pan, Lifeng | |
2019-08-01 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Myosin VI plays crucial roles in diverse cellular processes. In autophagy, Myosin VI can facilitate the maturation of autophagosomes through interactions with Tom1 and the autophagy receptors, Optineurin, NDP52 and TAX1BP1. Here, we report the high-resolution crystal structure of the C-terminal cargo-binding domain (CBD) of Myosin VI in complex with Tom1, which elucidates the mechanistic basis underpinning the specific interaction between Myosin VI and Tom1, and uncovers that the C-terminal CBD of Myosin VI adopts a unique cargo recognition mode to interact with Tom1 for tethering. Furthermore, we show that Myosin VI can serve as a bridging adaptor to simultaneously interact with Tom1 and autophagy receptors through two distinct interfaces. In all, our findings provide mechanistic insights into the interactions of Myosin VI with Tom1 and relevant autophagy receptors, and are valuable for further understanding the functions of these proteins in autophagy and the cargo recognition modes of Myosin VI. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000478014000001 |
WOS关键词 | AUTOPHAGY RECEPTOR ; UBIQUITIN RECOGNITION ; BINDING ; PROTEIN ; ACTIN ; OPTINEURIN ; ENDOCYTOSIS ; MOTOR ; MITOCHONDRIA ; DIMERIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203535 |
专题 | 资源环境科学 |
作者单位 | Univ Chinese Acad Sci, Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,State Key Lab Bioorgan &, Shanghai 200032, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, Shichen,Guo, Yujiao,Wang, Yingli,et al. Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Hu, Shichen.,Guo, Yujiao.,Wang, Yingli.,Li, Ying.,Fu, Tao.,...&Pan, Lifeng.(2019).Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.NATURE COMMUNICATIONS,10. |
MLA | Hu, Shichen,et al."Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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