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Methane emissions responsible for record-breaking atmospheric methane growth rates in 2020 and 2021 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Liang Feng, Paul I. Palmer, Robert J. Parker, Mark F. Lunt, and Hartmut Boesch
收藏  |  浏览/下载:10/0  |  提交时间:2022/06/24
Application of the high spatiotemporal resolution soil fugitive dust emission inventory compilation method based on CAMx model 期刊论文
Atmospheric Research, 2021
作者:  Tingkun Li, Simeng Ma, Weizhao Liang, Linxuan Li, ... Yinchang Feng
收藏  |  浏览/下载:7/0  |  提交时间:2021/07/27
A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载:12/0  |  提交时间:2020/12/22
Large Chinese land carbon sink estimated from atmospheric carbon dioxide data 期刊论文
Nature, 2020
作者:  Jing Wang;  Liang Feng;  Paul I. Palmer;  Yi Liu;  Shuangxi Fang;  Hartmut Bö;  sch;  Christopher W. O’;  Dell;  Xiaoping Tang;  Dongxu Yang;  Lixin Liu;  ChaoZong Xia
收藏  |  浏览/下载:13/0  |  提交时间:2020/11/09
Changing characteristics of atmospheric CH4 on the Tibetan Plateau, records from 1994 to 2017 at Mount Waliguan station 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Shuo Liu, Shuangxi Fang, Peng Liu, Miao Liang, Minrui Guo, and Zhaozhong Feng
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/09
Raindrop size distribution and microphysical characteristics of a great rainstorm in 2016 in Beijing, China 期刊论文
ATMOSPHERIC RESEARCH, 2020, 239
作者:  Luo, Li;  Xiao, Hui;  Yang, Huiling;  Chen, Haonan;  Guo, Jia;  Sun, Yue;  Feng, Liang
收藏  |  浏览/下载:12/0  |  提交时间:2020/08/18
Great rainstorm  Northern China  Raindrop size distribution  Precipitation microphysics  Z-R relation  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03
Dietary modifications for enhanced cancer therapy 期刊论文
NATURE, 2020, 579 (7800) : 507-517
作者:  Keller, Matthew D.;  Ching, Krystal L.;  Liang, Feng-Xia;  Dhabaria, Avantika;  Tam, Kayan;  Ueberheide, Beatrix M.;  Unutmaz, Derya;  Torres, Victor J.;  Cadwell, Ken
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host'  s diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.


  
A self-activating orphan receptor 期刊论文
NATURE, 2020, 579 (7797) : 35-35
作者:  Wang, Lin;  Wu, Juehui;  Li, Jun;  Yang, Hua;  Tang, Tianqi;  Liang, Haijiao;  Zuo, Mianyong;  Wang, Jie;  Liu, Haipeng;  Liu, Feng;  Chen, Jianxia;  Liu, Zhonghua;  Wang, Yang;  Peng, Cheng;  Wu, Xiangyang;  Zheng, Ruijuan;  Huang, Xiaochen;  Ran, Yajun;  Rao, Zihe;  Ge, Baoxue
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics.