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Stimulation of soil respiration by elevated CO2 is enhanced under nitrogen limitation in a decade-long grassland study 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Qun Gao;  Gangsheng Wang;  Kai Xue;  Yunfeng Yang;  Jianping Xie;  Hao Yu;  Shijie Bai;  Feifei Liu;  Zhili He;  Daliang Ning;  Sarah E. Hobbie;  Peter B. Reich;  Jizhong Zhou
收藏  |  浏览/下载:13/0  |  提交时间:2020/12/22
Global COVID-19 pandemic demands joint interventions for the suppression of future waves 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Ruiyun Li;  Bin Chen;  Tao Zhang;  Zhehao Ren;  Yimeng Song;  Yixiong Xiao;  Lin Hou;  Jun Cai;  Bo Xu;  Miao Li;  Karen Kie Yan Chan;  Ying Tu;  Mu Yang;  Jing Yang;  Zhaoyang Liu;  Chong Shen;  Che Wang;  Lei Xu;  Qiyong Liu;  Shuming Bao;  Jianqin Zhang;  Yuhai Bi;  Yuqi Bai;  Ke Deng;  Wusheng Zhang;  Wenyu Huang;  Jason D. Whittington;  Nils Chr. Stenseth;  Dabo Guan;  Peng Gong;  Bing Xu
收藏  |  浏览/下载:14/0  |  提交时间:2020/10/12
Nitrogen‐induced acidification, not N‐nutrient, dominates suppressive N effects on arbuscular mycorrhizal fungi 期刊论文
Global Change Biology, 2020
作者:  Shang Pan;  Yang Wang;  Yunpeng Qiu;  Dima Chen;  Lin Zhang;  Chenglong Ye;  Hui Guo;  Weixing Zhu;  Aiqun Chen;  Guohua Xu;  Yi Zhang;  Yongfei Bai;  Shuijin Hu
收藏  |  浏览/下载:8/0  |  提交时间:2020/09/30
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
Science, 2020
作者:  Wenhao Dai;  Bing Zhang;  Xia-Ming Jiang;  Haixia Su;  Jian Li;  Yao Zhao;  Xiong Xie;  Zhenming Jin;  Jingjing Peng;  Fengjiang Liu;  Chunpu Li;  You Li;  Fang Bai;  Haofeng Wang;  Xi Cheng;  Xiaobo Cen;  Shulei Hu;  Xiuna Yang;  Jiang Wang;  Xiang Liu;  Gengfu Xiao;  Hualiang Jiang;  Zihe Rao;  Lei-Ke Zhang;  Yechun Xu;  Haitao Yang;  Hong Liu
收藏  |  浏览/下载:18/0  |  提交时间:2020/06/22
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
Phosphorus alleviation of nitrogen-suppressed methane sink in global grasslands 期刊论文
ECOLOGY LETTERS, 2020, 23 (5) : 821-830
作者:  Zhang, Lihua;  Yuan, Fenghui;  Bai, Junhong;  Duan, Hongtao;  Gu, Xueying;  Hou, Longyu;  Huang, Yao;  Yang, Mingan;  He, Jin-Sheng;  Zhang, Zhenhua;  Yu, Lijun;  Song, Changchun;  Lipson, David A.;  Zona, Donatella;  Oechel, Walter;  Janssens, Ivan A.;  Xu, Xiaofeng
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/02
Grassland  methane  nitrogen  phosphorus  substrate competition theory  
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tang, Bai-Lu;  Yang, Jie;  Chen, Xiu-Lan;  Wang, Peng;  Zhao, Hui-Lin;  Su, Hai-Nan;  Li, Chun-Yang;  Yu, Yang;  Zhong, Shuai;  Wang, Lei;  Lidbury, Ian;  Ding, Haitao;  Wang, Min;  McMinn, Andrew;  Zhang, Xi-Ying;  Chen, Yin;  Zhang, Yu-Zhong
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
The evolutionary history of 2,658 cancers 期刊论文
NATURE, 2020, 578 (7793) : 122-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

Cancer develops through a process of somatic evolution(1,2). Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes(3). Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(4), we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.