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美国MAPP项目支持气候监测与风险评估 快报文章
气候变化快报,2022年第12期
作者:  刘燕飞
Microsoft Word(15Kb)  |  收藏  |  浏览/下载:684/0  |  提交时间:2022/06/20
Climate Program Office  climate risk monitoring  Modeling, Analysis, Predictions, and Projections (MAPP)  
Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:40/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T-reg cells 期刊论文
NATURE, 2020
作者:  Ma, Xiyu;  Claus, Lucas A. N.;  Leslie, Michelle E.;  Tao, Kai;  Wu, Zhiping;  Liu, Jun;  Yu, Xiao;  Li, Bo;  Zhou, Jinggeng;  Savatin, Daniel V.;  Peng, Junmin;  Tyler, Brett M.;  Heese, Antje;  Russinova, Eugenia;  He, Ping;  Shan, Libo
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/03

Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers(1). The functions of a large majority of disease-associated enhancers are unknown, in part owing to their distance from the genes they regulate, a lack of understanding of the cell types in which they operate, and our inability to recapitulate the biology of immune diseases in vitro. Here, using shared synteny to guide loss-of-function analysis of homologues of human enhancers in mice, we show that the prominent autoimmune and allergic disease risk locus at chromosome 11q13.5(2-7) contains a distal enhancer that is functional in CD4(+) regulatory T (T-reg) cells and required for T-reg-mediated suppression of colitis. The enhancer recruits the transcription factors STAT5 and NF-kappa B to mediate signal-driven expression of Lrrc32, which encodes the protein glycoprotein A repetitions predominant (GARP). Whereas disruption of the Lrrc32 gene results in early lethality, mice lacking the enhancer are viable but lack GARP expression in Foxp3(+) T-reg cells, which are unable to control colitis in a cell-transfer model of the disease. In human T-reg cells, the enhancer forms conformational interactions with the promoter of LRRC32 and enhancer risk variants are associated with reduced histone acetylation and GARP expression. Finally, functional fine-mapping of 11q13.5 using CRISPR-activation (CRISPRa) identifies a CRISPRa-responsive element in the vicinity of risk variant rs11236797 capable of driving GARP expression. These findings provide a mechanistic basis for association of the 11q13.5 risk locus with immune-mediated diseases and identify GARP as a potential target in their therapy.


Shared synteny guides loss-of-function analysis of human enhancer homologues in mice, identifying a distal enhancer at the autoimmune and allergic disease risk locus at chromosome 11q13.5 whose function in regulatory T cells provides a mechanistic basis for its role in disease.


  
Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.


  
Hard or soft flood adaptation? Advantages of a hybrid strategy for Shanghai 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 61
作者:  Du, Shiqiang;  Scussolini, Paolo;  Ward, Philip J.;  Zhang, Min;  Wen, Jiahong;  Wang, Luyang;  Koks, Elco;  Diaz-Loaiza, Andres;  Gao, Jun;  Ke, Qian;  Aerts, Jeroen C. J. H.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
Climate change  Nonstationarity  Coastal flood  Risk management  Cost-benefit analysis  
Policy integration: Do laws or actors integrate issues relevant to flood risk management in Switzerland? 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 61
作者:  Metz, Florence;  Angst, Mario;  Fischer, Manuel
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Policy integration  issue integration  flood risk management  adaptive governance  network analysis  bipartite network  
Random Fields Simplified: Preserving Marginal Distributions, Correlations, and Intermittency, With Applications From Rainfall to Humidity 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (2)
作者:  Papalexiou, Simon Michael;  Serinaldi, Francesco
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02
Random field simulation  Stochastic modelling  Spatiotemporal correlation structures  Precipitation simulation  Hydroclimatic processes simulation  Spatiotemporal risk analysis  
A comprehensive India-wide social vulnerability analysis: highlighting its influence on hydro-climatic risk 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (1)
作者:  Vittal, H.;  Karmakar, Subhankar;  Ghosh, Subimal;  Murtugudde, Raghu
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
data envelopment analysis  India  mortality  natural hazards  risk  social vulnerability  
Geographies of Algorithmic Violence: Redlining the Smart City 期刊论文
INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, 2019
作者:  Safransky, Sara
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
data-driven urbanism  algorithmic governance  urban planning  the post-political city  racial capitalism  racialization  risk  value  Market Value Analysis  Detroit  
Measuring security in the built environment: Evaluating urban vulnerability in a human-scale urban form 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 191
作者:  Shach-Pinsly, Dalit
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Urban security  Crime prevention  GIS analysis  Evaluation  Measurement  Risk assessment