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Internal state dynamics shape brainwide activity and foraging behaviour 期刊论文
NATURE, 2020, 577 (7789) : 239-+
作者:  Marques, Joao C.;  Li, Meng;  Schaak, Diane;  Robson, Drew N.;  Li, Jennifer M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

The brain has persistent internal states that can modulate every aspect of an animal'  s mental experience(1-4). In complex tasks such as foraging, the internal state is dynamic(5-8). Caenorhabditis elegans alternate between local search and global dispersal(5). Rodents and primates exhibit trade-offs between exploitation and exploration(6,7). However, fundamental questions remain about how persistent states are maintained in the brain, which upstream networks drive state transitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and decision-making to govern appropriate behaviour. Here, using tracking microscopy to monitor whole-brain neuronal activity at cellular resolution in freely moving zebrafish larvae(9), we show that zebrafish spontaneously alternate between two persistent internal states during foraging for live prey (Paramecia). In the exploitation state, the animal inhibits locomotion and promotes hunting, generating small, localized trajectories. In the exploration state, the animal promotes locomotion and suppresses hunting, generating long-ranging trajectories that enhance spatial dispersion. We uncover a dorsal raphe subpopulation with persistent activity that robustly encodes the exploitation state. The exploitation-state-encoding neurons, together with a multimodal trigger network that is associated with state transitions, form a stochastically activated nonlinear dynamical system. The activity of this oscillatory network correlates with a global retuning of sensorimotor transformations during foraging that leads to marked changes in both the motivation to hunt for prey and the accuracy of motor sequences during hunting. This work reveals an important hidden variable that shapes the temporal structure of motivation and decision-making.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Local and global consequences of reward-evoked striatal dopamine release 期刊论文
NATURE, 2020, 580 (7802) : 239-+
作者:  Wagner, Felix R.;  Dienemann, Christian;  Wang, Haibo;  Stuetzer, Alexandra;  Tegunov, Dimitry;  Urlaub, Henning;  Cramer, Patrick
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

The neurotransmitter dopamine is required for the reinforcement of actions by rewarding stimuli(1). Neuroscientists have tried to define the functions of dopamine in concise conceptual terms(2), but the practical implications of dopamine release depend on its diverse brain-wide consequences. Although molecular and cellular effects of dopaminergic signalling have been extensively studied(3), the effects of dopamine on larger-scale neural activity profiles are less well-understood. Here we combine dynamic dopamine-sensitive molecular imaging(4) and functional magnetic resonance imaging to determine how striatal dopamine release shapes local and global responses to rewarding stimulation in rat brains. We find that dopamine consistently alters the duration, but not the magnitude, of stimulus responses across much of the striatum, via quantifiable postsynaptic effects that vary across subregions. Striatal dopamine release also potentiates a network of distal responses, which we delineate using neurochemically dependent functional connectivity analyses. Hot spots of dopaminergic drive notably include cortical regions that are associated with both limbic and motor function. Our results reveal distinct neuromodulatory actions of striatal dopamine that extend well beyond its sites of peak release, and that result in enhanced activation of remote neural populations necessary for the performance of motivated actions. Our findings also suggest brain-wide biomarkers of dopaminergic function and could provide a basis for the improved interpretation of neuroimaging results that are relevant to learning and addiction.


Molecular and functional magnetic resonance imaging in the rat reveals distinct neuromodulatory effects of striatal dopamine that extend beyond peak release sites and activate remote neural populations necessary for performing motivated actions.


  
Aligning prosumers with the electricity wholesale market - The impact of time-varying price signals and fixed network charges on solar self-consumption 期刊论文
ENERGY POLICY, 2019, 134
作者:  Klein, Martin;  Ziade, Ahmad;  de Vries, Laurens
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
Photovoltaics  Prosumer  Market alignment  PV-battery systems  Fixed network charges  Dynamic prices  
Extreme Memory of Initial Conditions in Numerical Landscape Evolution Models 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (12) : 6563-6573
作者:  Kwang, J. S.;  Parker, G.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/26
landscape evolution modeling  dynamic equilibrium  drainage network reorganization  initial conditions  divide migration  lateral channel migration  
The Role of Restoration and Key Ecological Invasion Mechanisms in Optimal Spatial-Dynamic Management of Invasive Species 期刊论文
ECOLOGICAL ECONOMICS, 2018, 151: 44-54
作者:  Albers, Heidi J.;  Hall, Kim Meyer;  Lee, Katherine D.;  Taleghan, Majid Alkaee;  Dietterich, Thomas G.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Spatial  Dynamic optimization  Meta-population  Dispersal  Species interactions  Species competition  Bio-invasions  Invasive species  Ecology  River network  Restoration  Habitat  Riparian  
Assessing fairness of dynamic grid tariffs 期刊论文
ENERGY POLICY, 2017, 108
作者:  Neuteleers, Stijn;  Mulder, Machiel;  Hindriks, Frank
收藏  |  浏览/下载:1/0  |  提交时间:2019/04/09
Network tariffs  Fairness Dynamic prices  Peak pricing  Congestion  Acceptability  
Network analysis reveals strongly localized impacts of El Nino 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (29) : 7543-7548
作者:  Fan, Jingfang;  Meng, Jun;  Ashkenazy, Yosef;  Havlin, Shlomo;  Schellnhuber, Hans Joachim
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
climate  dynamic network  ENSO