Internal state dynamics shape brainwide activity and foraging behaviour

doi:10.1038/s41586-019-1858-z

GSTDTAP > 地球科学

DOI	10.1038/s41586-019-1858-z
	Internal state dynamics shape brainwide activity and foraging behaviour
	Marques, Joao C.1,2; Li, Meng 1,3; Schaak, Diane 1; Robson, Drew N.1,3; Li, Jennifer M.1,3
	2020-05-01
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	577 期号:7789 页码:239-+
文章类型	Article
语种	英语
国家	USA; Portugal; Germany
英文关键词	The brain has persistent internal states that can modulate every aspect of an animal' s mental experience(1-4). In complex tasks such as foraging, the internal state is dynamic(5-8). Caenorhabditis elegans alternate between local search and global dispersal(5). Rodents and primates exhibit trade-offs between exploitation and exploration(6,7). However, fundamental questions remain about how persistent states are maintained in the brain, which upstream networks drive state transitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and decision-making to govern appropriate behaviour. Here, using tracking microscopy to monitor whole-brain neuronal activity at cellular resolution in freely moving zebrafish larvae(9), we show that zebrafish spontaneously alternate between two persistent internal states during foraging for live prey (Paramecia). In the exploitation state, the animal inhibits locomotion and promotes hunting, generating small, localized trajectories. In the exploration state, the animal promotes locomotion and suppresses hunting, generating long-ranging trajectories that enhance spatial dispersion. We uncover a dorsal raphe subpopulation with persistent activity that robustly encodes the exploitation state. The exploitation-state-encoding neurons, together with a multimodal trigger network that is associated with state transitions, form a stochastically activated nonlinear dynamical system. The activity of this oscillatory network correlates with a global retuning of sensorimotor transformations during foraging that leads to marked changes in both the motivation to hunt for prey and the accuracy of motor sequences during hunting. This work reveals an important hidden variable that shapes the temporal structure of motivation and decision-making.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000506682500041
WOS关键词	SEROTONERGIC NEURONS ; LARVAL ZEBRAFISH
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281229
专题	地球科学资源环境科学气候变化
作者单位	1.Harvard Univ, Rowland Inst, Cambridge, MA USA; 2.Champalimaud Ctr Unknown, Champalimaud Res, Lisbon, Portugal; 3.Max Planck Inst Biol Cybernet, Tubingen, Germany
推荐引用方式 GB/T 7714	Marques, Joao C.,Li, Meng,Schaak, Diane,et al. Internal state dynamics shape brainwide activity and foraging behaviour[J]. NATURE,2020,577(7789):239-+.
APA	Marques, Joao C.,Li, Meng,Schaak, Diane,Robson, Drew N.,&Li, Jennifer M..(2020).Internal state dynamics shape brainwide activity and foraging behaviour.NATURE,577(7789),239-+.
MLA	Marques, Joao C.,et al."Internal state dynamics shape brainwide activity and foraging behaviour".NATURE 577.7789(2020):239-+.