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3D genomics across the tree of life reveals condensin II as a determinant of architecture type 期刊论文
Science, 2021
作者:  Claire Hoencamp;  Olga Dudchenko;  Ahmed M. O. Elbatsh;  Sumitabha Brahmachari;  Jonne A. Raaijmakers;  Tom van Schaik;  Ángela Sedeño Cacciatore;  Vinícius G. Contessoto;  Roy G. H. P. van Heesbeen;  Bram van den Broek;  Aditya N. Mhaskar;  Hans Teunissen;  Brian Glenn St Hilaire;  David Weisz;  Arina D. Omer;  Melanie Pham;  Zane Colaric;  Zhenzhen Yang;  Suhas S. P. Rao;  Namita Mitra;  Christopher Lui;  Weijie Yao;  Ruqayya Khan;  Leonid L. Moroz;  Andrea Kohn;  Judy St. Leger;  Alexandria Mena;  Karen Holcroft;  Maria Cristina Gambetta;  Fabian Lim;  Emma Farley;  Nils Stein;  Alexander Haddad;  Daniel Chauss;  Ayse Sena Mutlu;  Meng C. Wang;  Neil D. Young;  Evin Hildebrandt;  Hans H. Cheng;  Christopher J. Knight;  Theresa L. U. Burnham;  Kevin A. Hovel;  Andrew J. Beel;  Pierre-Jean Mattei;  Roger D. Kornberg;  Wesley C. Warren;  Gregory Cary;  José Luis Gómez-Skarmeta;  Veronica Hinman;  Kerstin Lindblad-Toh;  Federica Di Palma;  Kazuhiro Maeshima;  Asha S. Multani;  Sen Pathak;  Liesl Nel-Themaat;  Richard R. Behringer;  Parwinder Kaur;  René H. Medema;  Bas van Steensel;  Elzo de Wit;  José N. Onuchic;  Michele Di Pierro;  Erez Lieberman Aiden;  Benjamin D. Rowland
收藏  |  浏览/下载:13/0  |  提交时间:2021/06/07
Divergence of Arctic shrub growth associated with sea ice decline 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Agata Buchwal;  Patrick F. Sullivan;  Marc Macias-Fauria;  Eric Post;  Isla H. Myers-Smith;  Julienne C. Stroeve;  Daan Blok;  Ken D. Tape;  Bruce C. Forbes;  Pascale Ropars;  Esther Lévesque;  Bo Elberling;  Sandra Angers-Blondin;  Joseph S. Boyle;  Stéphane Boudreau;  Noémie Boulanger-Lapointe;  Cassandra Gamm;  Martin Hallinger;  Grzegorz Rachlewicz;  Amanda Young;  Pentti Zetterberg;  Jeffrey M. Welker
收藏  |  浏览/下载:13/0  |  提交时间:2020/12/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:27/0  |  提交时间:2020/12/07
A triple-star system with a misaligned and warped circumstellar disk shaped by disk tearing 期刊论文
Science, 2020
作者:  Stefan Kraus;  Alexander Kreplin;  Alison K. Young;  Matthew R. Bate;  John D. Monnier;  Tim J. Harries;  Henning Avenhaus;  Jacques Kluska;  Anna S. E. Laws;  Evan A. Rich;  Matthew Willson;  Alicia N. Aarnio;  Fred C. Adams;  Sean M. Andrews;  Narsireddy Anugu;  Jaehan Bae;  Theo ten Brummelaar;  Nuria Calvet;  Michel Curé;  Claire L. Davies;  Jacob Ennis;  Catherine Espaillat;  Tyler Gardner;  Lee Hartmann;  Sasha Hinkley;  Aaron Labdon;  Cyprien Lanthermann;  Jean-Baptiste LeBouquin;  Gail H. Schaefer;  Benjamin R. Setterholm;  David Wilner;  Zhaohuan Zhu
收藏  |  浏览/下载:8/0  |  提交时间:2020/09/08
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic 期刊论文
Science, 2020
作者:  Emily N. Chin;  Chenguang Yu;  Vincent F. Vartabedian;  Ying Jia;  Manoj Kumar;  Ana M. Gamo;  William Vernier;  Sabrina H. Ali;  Mildred Kissai;  Daniel C. Lazar;  Nhan Nguyen;  Laura E. Pereira;  Brent Benish;  Ashley K. Woods;  Sean B. Joseph;  Alan Chu;  Kristen A. Johnson;  Philipp N. Sander;  Francisco Martínez-Peña;  Eric N. Hampton;  Travis S. Young;  Dennis W. Wolan;  Arnab K. Chatterjee;  Peter G. Schultz;  H. Michael Petrassi;  John R. Teijaro;  Luke L. Lairson
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
Southern Ocean carbon sink enhanced by sea-ice feedbacks at the Antarctic Cold Reversal 期刊论文
NATURE GEOSCIENCE, 2020, 13 (7) : 489-+
作者:  Fogwill, C. J.;  Turney, C. S. M.;  Menviel, L.;  Baker, A.;  Weber, M. E.;  Ellis, B.;  Thomas, Z. A.;  Golledge, N. R.;  Etheridge, D.;  Rubino, M.;  Thornton, D. P.;  van Ommen, T. D.;  Moy, A. D.;  Curran, M. A. J.;  Davies, S.;  Bird, M., I;  Munksgaard, N. C.;  Rootes, C. M.;  Millman, H.;  Vohra, J.;  Rivera, A.;  Mackintosh, A.;  Pike, J.;  Hall, I. R.;  Bagshaw, E. A.;  Rainsley, E.;  Bronk-Ramsey, C.;  Montenari, M.;  Cage, A. G.;  Harris, M. R. P.;  Jones, R.;  Power, A.;  Love, J.;  Young, J.;  Weyrich, L. S.;  Cooper, A.
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
Partitioning of cancer therapeutics in nuclear condensates 期刊论文
Science, 2020
作者:  Isaac A. Klein;  Ann Boija;  Lena K. Afeyan;  Susana Wilson Hawken;  Mengyang Fan;  Alessandra Dall'Agnese;  Ozgur Oksuz;  Jonathan E. Henninger;  Krishna Shrinivas;  Benjamin R. Sabari;  Ido Sagi;  Victoria E. Clark;  Jesse M. Platt;  Mrityunjoy Kar;  Patrick M. McCall;  Alicia V. Zamudio;  John C. Manteiga;  Eliot L. Coffey;  Charles H. Li;  Nancy M. Hannett;  Yang Eric Guo;  Tim-Michael Decker;  Tong Ihn Lee;  Tinghu Zhang;  Jing-Ke Weng;  Dylan J. Taatjes;  Arup Chakraborty;  Phillip A. Sharp;  Young Tae Chang;  Anthony A. Hyman;  Nathanael S. Gray;  Richard A. Young
收藏  |  浏览/下载:18/0  |  提交时间:2020/06/22
Topographic Influence on the African Easterly Jet and African Easterly Wave Energetics 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (8)
作者:  Hamilton, H. L.;  Nunez Ocasio, K. M.;  Evans, J. L.;  Young, G. S.;  Fuentes, J. D.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
African Easterly Waves  African Easterly Jet  topographic influences  West African monsoon  idealized numerical modeling  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis 期刊论文
NATURE, 2020, 578 (7796) : 577-+
作者:  Bogomilov, M.;  Tsenov, R.;  Vankova-Kirilova, G.;  Song, Y. P.;  Tang, J. Y.;  Li, Z. H.;  Bertoni, R.;  Bonesini, M.;  Chignoli, F.;  Mazza, R.;  Palladino, V;  de Bari, A.;  Orestano, D.;  Tortora, L.;  Kuno, Y.;  Sakamoto, H.;  Sato, A.;  Ishimoto, S.;  Chung, M.;  Sung, C. K.;  Filthaut, F.;  Jokovic, D.;  Maletic, D.;  Savic, M.;  Jovancevic, N.;  Nikolov, J.;  Vretenar, M.;  Ramberger, S.;  Asfandiyarov, R.;  Blondel, A.;  Drielsma, F.;  Karadzhov, Y.;  Boyd, S.;  Greis, J. R.;  Lord, T.;  Pidcott, C.;  Taylor, I;  Charnley, G.;  Collomb, N.;  Dumbell, K.;  Gallagher, A.;  Grant, A.;  Griffiths, S.;  Hartnett, T.;  Martlew, B.;  Moss, A.;  Muir, A.;  Mullacrane, I;  Oates, A.;  Owens, P.;  Stokes, G.;  Warburton, P.;  White, C.;  Adams, D.;  Bayliss, V;  Boehm, J.;  Bradshaw, T. W.;  Brown, C.;  Courthold, M.;  Govans, J.;  Hills, M.;  Lagrange, J-B;  Macwaters, C.;  Nichols, A.;  Preece, R.;  Ricciardi, S.;  Rogers, C.;  Stanley, T.;  Tarrant, J.;  Tucker, M.;  Watson, S.;  Wilson, A.;  Bayes, R.;  Nugent, J. C.;  Soler, F. J. P.;  Chatzitheodoridis, G. T.;  Dick, A. J.;  Ronald, K.;  Whyte, C. G.;  Young, A. R.;  Gamet, R.;  Cooke, P.;  Blackmore, V. J.;  Colling, D.;  Dobbs, A.;  Dornan, P.;  Franchini, P.;  Hunt, C.;  Jurj, P. B.;  Kurup, A.;  Long, K.;  Martyniak, J.;  Middleton, S.;  Pasternak, J.;  Uchida, M. A.;  Cobb, J. H.;  Booth, C. N.;  Hodgson, P.;  Langlands, J.;  Overton, E.;  Pec, V;  Smith, P. J.;  Wilbur, S.;  Ellis, M.;  Gardener, R. B. S.;  Kyberd, P.;  Nebrensky, J. J.;  DeMello, A.;  Gourlay, S.;  Lambert, A.;  Li, D.;  Luo, T.;  Prestemon, S.;  Virostek, S.;  Palmer, M.;  Witte, H.;  Adey, D.;  Bross, A. D.;  Bowring, D.;  Liu, A.;  Neuffer, D.;  Popovic, M.;  Rubinov, P.;  Freemire, B.;  Hanlet, P.;  Kaplan, D. M.;  Mohayai, T. A.;  Rajaram, D.;  Snopok, P.;  Torun, Y.;  Cremaldi, L. M.;  Sanders, D. A.;  Summers, D. J.;  Coney, L. R.;  Hanson, G. G.;  Heidt, C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues(1-4). H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and cellular processes. However, whether sensors for H2O2 also exist on the cell surface remains unknown. In plant cells, H2O2 triggers an influx of Ca2+ ions, which is thought to be involved in H2O2 sensing and signalling. Here, by using forward genetic screens based on Ca2+ imaging, we isolated hydrogen-peroxide-induced Ca(2+)increases (hpca) mutants in Arabidopsis, and identified HPCA1 as a leucine-rich-repeat receptor kinase belonging to a previously uncharacterized subfamily that features two extra pairs of cysteine residues in the extracellular domain. HPCA1 is localized to the plasma membrane and is activated by H2O2 via covalent modification of extracellular cysteine residues, which leads to autophosphorylation of HPCA1. HPCA1 mediates H2O2-induced activation of Ca2+ channels in guard cells and is required for stomatal closure. Our findings help to identify how the perception of extracellular H2O2 is integrated with responses to various external stresses and internal cues in plants, and have implications for the design of crops with enhanced fitness.


HPCA1, a member of a previously uncharacterized subfamily of leucine-rich-repeat receptor-like kinases, is the hydrogen-peroxide sensor at the plasma membrane in Arabidopsis.