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In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort 期刊论文
Environmental Health Perspectives, 2021
作者:  Mingyu Zhang;  Tiange Liu;  Guoying Wang;  Jessie P. Buckley;  Eliseo Guallar;  Xiumei Hong;  Mei-Cheng Wang;  Marsha Wills-Karp;  Xiaobin Wang;  Noel T. Mueller
收藏  |  浏览/下载:13/0  |  提交时间:2021/07/27
Characteristics and source apportionment of ambient single particles in Tianjin, China: The close association between oxalic acid and biomass burning 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Xu, Jiao;  Tian, Yingze;  Cheng, Chunlei;  Wang, Chuang;  Lin, Qiuju;  Li, Mei;  Wang, Xiaofei;  Shi, Guoliang
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Single particle  Oxalic acid  Biomass burning  Source contribution  PMF  SPAMS  
Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wei, Yi-Ming;  Han, Rong;  Wang, Ce;  Yu, Biying;  Liang, Qiao-Mei;  Yuan, Xiao-Chen;  Chang, Junjie;  Zhao, Qingyu;  Liao, Hua;  Tang, Baojun;  Yan, Jinyue;  Cheng, Lijing;  Yang, Zili
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/13
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:142/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Multi-method determination of the below-cloud wet scavenging coefficients of aerosols in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (24) : 15569-15581
作者:  Xu, Danhui;  Ge, Baozhu;  Chen, Xueshun;  Sun, Yele;  Cheng, Nianliang;  Li, Mei;  Pan, Xiaole;  Ma, Zhiqiang;  Pan, Yuepeng;  Wang, Zifa
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/17
Possible heterogeneous chemistry of hydroxymethanesulfonate (HMS) in northern China winter haze 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (2) : 1357-1371
作者:  Song, Shaojie;  Gao, Meng;  Xu, Weiqi;  Sun, Yele;  Worsnop, Douglas R.;  Jayne, John T.;  Zhang, Yuzhong;  Zhu, Lei;  Li, Mei;  Zhou, Zhen;  Cheng, Chunlei;  Lv, Yibing;  Wang, Ying;  Peng, Wei;  Xu, Xiaobin;  Lin, Nan;  Wang, Yuxuan;  Wang, Shuxiao;  Munger, J. William;  Jacob, Daniel J.;  McElroy, Michael B.
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/09
Forecasting severe convective storms with WRF-based RTFDDA radar data assimilation in Guangdong, China 期刊论文
ATMOSPHERIC RESEARCH, 2018, 209: 131-143
作者:  Huang, Yongjie;  Liu, Yubao;  Xu, Mei;  Liu, Yuewei;  Pan, Linlin;  Wang, Haoliang;  Cheng, Will Y. Y.;  Jiang, Ying;  Lan, Hongping;  Yang, Honglong;  Wei, Xiaolin;  Zong, Rong;  Cao, Chunyan
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Severe convective storms  RTFDDA  Radar data assimilation  Latent heating  Nowcasting  
Incorporating geostationary lightning data into a radar reflectivity based hydrometeor retrieval method: An observing system simulation experiment 期刊论文
ATMOSPHERIC RESEARCH, 2018, 209: 1-13
作者:  Wang, Haoliang;  Liu, Yubao;  Zhao, Tianliang;  Xu, Mei;  Liu, Yuewei;  Guo, Fengxia;  Cheng, William Y. Y.;  Feng, Shuanglei;  Mansell, Edward R.;  Fierro, Alexandre O.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Lightning  Hydrometeor retrieval  Data assimilation  Numerical weather prediction  Observing system simulation experiment  
LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Liu, Cui-Yun;  Zhang, Yu-Hui;  Li, Rui-Bei;  Zhou, Lu-Yu;  An, Tao;  Zhang, Rong-Cheng;  Zhai, Mei;  Huang, Yan;  Yan, Kao-Wen;  Dong, Yan-Han;  Ponnusamy, Murugavel;  Shan, Chan;  Xu, Sheng;  Wang, Qi;  Zhang, Yan-Hui;  Zhang, Jian;  Wang, Kun
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Improving Lightning and Precipitation Prediction of Severe Convection Using Lightning Data Assimilation With NCAR WRF-RTFDDA 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2017, 122 (22)
作者:  Wang, Haoliang;  Liu, Yubao;  Cheng, William Y. Y.;  Zhao, Tianliang;  Xu, Mei;  Liu, Yuewei;  Shen, Si;  Calhoun, Kristin M.;  Fierro, Alexandre O.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
numerical weather forecast  lightning  data assimilation  cloud microphysics