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DOI | 10.1038/s41467-018-05147-y |
LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription | |
Liu, Cui-Yun1; Zhang, Yu-Hui2; Li, Rui-Bei3; Zhou, Lu-Yu1; An, Tao2; Zhang, Rong-Cheng2; Zhai, Mei2; Huang, Yan2; Yan, Kao-Wen1; Dong, Yan-Han1; Ponnusamy, Murugavel1; Shan, Chan1; Xu, Sheng1; Wang, Qi1; Zhang, Yan-Hui1; Zhang, Jian2; Wang, Kun1 | |
2018-01-02 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H2O2 and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419306000020 |
WOS关键词 | LONG NONCODING RNA ; GENE-EXPRESSION ; X-CHROMOSOME ; STRESS ; CHROMATIN ; HEART ; P53 ; DIFFERENTIATION ; CARDIOMYOCYTES ; APOPTOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203897 |
专题 | 资源环境科学 |
作者单位 | 1.Qingdao Univ, Coll Med, Inst Translat Med, Ctr Dev Cardiol, Qingdao 266021, Peoples R China; 2.Chinese Acad Med Sci, Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp,Heart Failure Ctr,State Key Lab Cardio, Beijing 100037, Peoples R China; 3.Northwestern Univ, Sch Profess Studies, Chicago, IL 60611 USA |
推荐引用方式 GB/T 7714 | Liu, Cui-Yun,Zhang, Yu-Hui,Li, Rui-Bei,et al. LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Liu, Cui-Yun.,Zhang, Yu-Hui.,Li, Rui-Bei.,Zhou, Lu-Yu.,An, Tao.,...&Wang, Kun.(2018).LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription.NATURE COMMUNICATIONS,9. |
MLA | Liu, Cui-Yun,et al."LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription".NATURE COMMUNICATIONS 9(2018). |
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