GSTDTAP

浏览/检索结果: 共25条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Approaching the motional ground state of a 10-kg object 期刊论文
Science, 2021
作者:  Chris Whittle;  Evan D. Hall;  Sheila Dwyer;  Nergis Mavalvala;  Vivishek Sudhir;  R. Abbott;  A. Ananyeva;  C. Austin;  L. Barsotti;  J. Betzwieser;  C. D. Blair;  A. F. Brooks;  D. D. Brown;  A. Buikema;  C. Cahillane;  J. C. Driggers;  A. Effler;  A. Fernandez-Galiana;  P. Fritschel;  V. V. Frolov;  T. Hardwick;  M. Kasprzack;  K. Kawabe;  N. Kijbunchoo;  J. S. Kissel;  G. L. Mansell;  F. Matichard;  L. McCuller;  T. McRae;  A. Mullavey;  A. Pele;  R. M. S. Schofield;  D. Sigg;  M. Tse;  G. Vajente;  D. C. Vander-Hyde;  Hang Yu;  Haocun Yu;  C. Adams;  R. X. Adhikari;  S. Appert;  K. Arai;  J. S. Areeda;  Y. Asali;  S. M. Aston;  A. M. Baer;  M. Ball;  S. W. Ballmer;  S. Banagiri;  D. Barker;  J. Bartlett;  B. K. Berger;  D. Bhattacharjee;  G. Billingsley;  S. Biscans;  R. M. Blair;  N. Bode;  P. Booker;  R. Bork;  A. Bramley;  K. C. Cannon;  X. Chen;  A. A. Ciobanu;  F. Clara;  C. M. Compton;  S. J. Cooper;  K. R. Corley;  S. T. Countryman;  P. B. Covas;  D. C. Coyne;  L. E. H. Datrier;  D. Davis;  C. Di Fronzo;  K. L. Dooley;  P. Dupej;  T. Etzel;  M. Evans;  T. M. Evans;  J. Feicht;  P. Fulda;  M. Fyffe;  J. A. Giaime;  K. D. Giardina;  P. Godwin;  E. Goetz;  S. Gras;  C. Gray;  R. Gray;  A. C. Green;  E. K. Gustafson;  R. Gustafson;  J. Hanks;  J. Hanson;  R. K. Hasskew;  M. C. Heintze;  A. F. Helmling-Cornell;  N. A. Holland;  J. D. Jones;  S. Kandhasamy;  S. Karki;  P. J. King;  Rahul Kumar;  M. Landry;  B. B. Lane;  B. Lantz;  M. Laxen;  Y. K. Lecoeuche;  J. Leviton;  J. Liu;  M. Lormand;  A. P. Lundgren;  R. Macas;  M. MacInnis;  D. M. Macleod;  S. Márka;  Z. Márka;  D. V. Martynov;  K. Mason;  T. J. Massinger;  R. McCarthy;  D. E. McClelland;  S. McCormick;  J. McIver;  G. Mendell;  K. Merfeld;  E. L. Merilh;  F. Meylahn;  T. Mistry;  R. Mittleman;  G. Moreno;  C. M. Mow-Lowry;  S. Mozzon;  T. J. N. Nelson;  P. Nguyen;  L. K. Nuttall;  J. Oberling;  Richard J. Oram;  C. Osthelder;  D. J. Ottaway;  H. Overmier;  J. R. Palamos;  W. Parker;  E. Payne;  R. Penhorwood;  C. J. Perez;  M. Pirello;  H. Radkins;  K. E. Ramirez;  J. W. Richardson;  K. Riles;  N. A. Robertson;  J. G. Rollins;  C. L. Romel;  J. H. Romie;  M. P. Ross;  K. Ryan;  T. Sadecki;  E. J. Sanchez;  L. E. Sanchez;  T. R. Saravanan;  R. L. Savage;  D. Schaetz;  R. Schnabel;  E. Schwartz;  D. Sellers;  T. Shaffer;  B. J. J. Slagmolen;  J. R. Smith;  S. Soni;  B. Sorazu;  A. P. Spencer;  K. A. Strain;  L. Sun;  M. J. Szczepańczyk;  M. Thomas;  P. Thomas;  K. A. Thorne;  K. Toland;  C. I. Torrie;  G. Traylor;  A. L. Urban;  G. Valdes;  P. J. Veitch;  K. Venkateswara;  G. Venugopalan;  A. D. Viets;  T. Vo;  C. Vorvick;  M. Wade;  R. L. Ward;  J. Warner;  B. Weaver;  R. Weiss;  B. Willke;  C. C. Wipf;  L. Xiao;  H. Yamamoto;  L. Zhang;  M. E. Zucker;  J. Zweizig
收藏  |  浏览/下载:16/0  |  提交时间:2021/06/24
Greenhouse Gas and Ice Volume Drive Pleistocene Indian Summer Monsoon Precipitation Isotope Variability 期刊论文
Geophysical Research Letters, 2021
作者:  S. M. McGrath;  S. C. Clemens;  Y. Haung;  M. Yamamoto
收藏  |  浏览/下载:7/0  |  提交时间:2021/02/17
Daytime dynamo electrodynamics with spiral currents driven by strong winds revealed by vapor trails and sounding rocket probes 期刊论文
Geophysical Research Letters, 2020
作者:  R. Pfaff;  M. Larsen;  T. Abe;  H. Habu;  J. Clemmons;  H. Freudenreich;  D. Rowland;  T. Bullett;  M.‐;  Y. Yamamoto;  S. Watanabe;  Y. Kakinami;  T. Yokoyama;  J. Mabie;  J. Klenzing;  R. Bishop;  R. Walterscheid;  M. Yamamoto;  Y. Yamazaki;  N. Murphy;  V. Angelopoulos
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/21
Opinion: Midwater ecosystems must be considered when evaluating environmental risks of deep-sea mining 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Jeffrey C. Drazen;  Craig R. Smith;  Kristina M. Gjerde;  Steven H. D. Haddock;  Glenn S. Carter;  C. Anela Choy;  Malcolm R. Clark;  Pierre Dutrieux;  Erica Goetze;  Chris Hauton;  Mariko Hatta;  J. Anthony Koslow;  Astrid B. Leitner;  Aude Pacini;  Jessica N. Perelman;  Thomas Peacock;  Tracey T. Sutton;  Les Watling;  Hiroyuki Yamamoto
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/14
Dilatory and Downward Development of 3-m Scale Irregularities in the Funnel-Like Region of a Rapidly Rising Equatorial Plasma Bubble 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Ram, S. Tulasi;  Ajith, K. K.;  Yokoyama, T.;  Yamamoto, M.;  Hozumi, K.;  Shiokawa, K.;  Otsuka, Y.;  Li, G.
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/16
equatorial plasma bubble  ionospheric scintillation  electric fields and model simulations  
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis 期刊论文
NATURE, 2020, 577 (7789) : 260-+
作者:  Kakiuchi, Nobuyuki;  Yoshida, Kenichi;  Uchino, Motoi;  Kihara, Takako;  Akaki, Kotaro;  Inoue, Yoshikage;  Kawada, Kenji;  Nagayama, Satoshi;  Yokoyama, Akira;  Yamamoto, Shuji;  Matsuura, Minoru;  Horimatsu, Takahiro;  Hirano, Tomonori;  Goto, Norihiro;  Takeuchi, Yasuhide;  Ochi, Yotaro;  Shiozawa, Yusuke;  Kogure, Yasunori;  Watatani, Yosaku;  Fujii, Yoichi;  Kim, Soo Ki;  Kon, Ayana;  Kataoka, Keisuke;  Yoshizato, Tetsuichi;  Nakagawa, Masahiro M.;  Yoda, Akinori;  Nanya, Yasuhito;  Makishima, Hideki;  Shiraishi, Yuichi;  Chiba, Kenichi;  Tanaka, Hiroko;  Sanada, Masashi;  Sugihara, Eiji;  Sato, Taka-aki;  Maruyama, Takashi;  Miyoshi, Hiroyuki;  Taketo, Makoto Mark;  Oishi, Jun;  Inagaki, Ryosaku;  Ueda, Yutaka;  Okamoto, Shinya;  Okajima, Hideaki;  Sakai, Yoshiharu;  Sakurai, Takaki;  Haga, Hironori;  Hirota, Seiichi;  Ikeuchi, Hiroki;  Nakase, Hiroshi;  Marusawa, Hiroyuki;  Chiba, Tsutomu;  Takeuchi, Osamu;  Miyano, Satoru;  Seno, Hiroshi;  Ogawa, Seishi
收藏  |  浏览/下载:78/0  |  提交时间:2020/07/03

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer(1-3). However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer development, remains unknown. Here we show that in patients with ulcerative colitis, the inflamed intestine undergoes widespread remodelling by pervasive clones, many of which are positively selected by acquiring mutations that commonly involve the NFKBIZ, TRAF3IP2, ZC3H12A, PIGR and HNRNPF genes and are implicated in the downregulation of IL-17 and other pro-inflammatory signals. Mutational profiles vary substantially between colitis-associated cancer and non-dysplastic tissues in ulcerative colitis, which indicates that there are distinct mechanisms of positive selection in both tissues. In particular, mutations in NFKBIZ are highly prevalent in the epithelium of patients with ulcerative colitis but rarely found in both sporadic and colitis-associated cancer, indicating that NFKBIZ-mutant cells are selected against during colorectal carcinogenesis. In further support of this negative selection, we found that tumour formation was significantly attenuated in Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells. Our results highlight common and discrete mechanisms of clonal selection in inflammatory tissues, which reveal unexpected cancer vulnerabilities that could potentially be exploited for therapeutics in colorectal cancer.


  
Sample collection from asteroid (162173) Ryugu by Hayabusa2: Implications for surface evolution 期刊论文
Science, 2020
作者:  T. Morota;  S. Sugita;  Y. Cho;  M. Kanamaru;  E. Tatsumi;  N. Sakatani;  R. Honda;  N. Hirata;  H. Kikuchi;  M. Yamada;  Y. Yokota;  S. Kameda;  M. Matsuoka;  H. Sawada;  C. Honda;  T. Kouyama;  K. Ogawa;  H. Suzuki;  K. Yoshioka;  M. Hayakawa;  N. Hirata;  M. Hirabayashi;  H. Miyamoto;  T. Michikami;  T. Hiroi;  R. Hemmi;  O. S. Barnouin;  C. M. Ernst;  K. Kitazato;  T. Nakamura;  L. Riu;  H. Senshu;  H. Kobayashi;  S. Sasaki;  G. Komatsu;  N. Tanabe;  Y. Fujii;  T. Irie;  M. Suemitsu;  N. Takaki;  C. Sugimoto;  K. Yumoto;  M. Ishida;  H. Kato;  K. Moroi;  D. Domingue;  P. Michel;  C. Pilorget;  T. Iwata;  M. Abe;  M. Ohtake;  Y. Nakauchi;  K. Tsumura;  H. Yabuta;  Y. Ishihara;  R. Noguchi;  K. Matsumoto;  A. Miura;  N. Namiki;  S. Tachibana;  M. Arakawa;  H. Ikeda;  K. Wada;  T. Mizuno;  C. Hirose;  S. Hosoda;  O. Mori;  T. Shimada;  S. Soldini;  R. Tsukizaki;  H. Yano;  M. Ozaki;  H. Takeuchi;  Y. Yamamoto;  T. Okada;  Y. Shimaki;  K. Shirai;  Y. Iijima;  H. Noda;  S. Kikuchi;  T. Yamaguchi;  N. Ogawa;  G. Ono;  Y. Mimasu;  K. Yoshikawa;  T. Takahashi;  Y. Takei;  A. Fujii;  S. Nakazawa;  F. Terui;  S. Tanaka;  M. Yoshikawa;  T. Saiki;  S. Watanabe;  Y. Tsuda
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).


  
Two Decades of Ocean Acidification in the Surface Waters of the Beaufort Gyre, Arctic Ocean: Effects of Sea Ice Melt and Retreat From 1997-2016 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Zhang, Y.;  Yamamoto-Kawai, M.;  Williams, W. J.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Dietary salt promotes cognitive impairment through tau phosphorylation (vol 574, pg 686, 2019) 期刊论文
NATURE, 2020, 578 (7793) : E9-E9
作者:  Kakiuchi, Nobuyuki;  Yoshida, Kenichi;  Uchino, Motoi;  Kihara, Takako;  Akaki, Kotaro;  Inoue, Yoshikage;  Kawada, Kenji;  Nagayama, Satoshi;  Yokoyama, Akira;  Yamamoto, Shuji;  Matsuura, Minoru;  Horimatsu, Takahiro;  Hirano, Tomonori;  Goto, Norihiro;  Takeuchi, Yasuhide;  Ochi, Yotaro;  Shiozawa, Yusuke;  Kogure, Yasunori;  Watatani, Yosaku;  Fujii, Yoichi;  Kim, Soo Ki;  Kon, Ayana;  Kataoka, Keisuke;  Yoshizato, Tetsuichi;  Nakagawa, Masahiro M.;  Yoda, Akinori;  Nanya, Yasuhito;  Makishima, Hideki;  Shiraishi, Yuichi;  Chiba, Kenichi;  Tanaka, Hiroko;  Sanada, Masashi;  Sugihara, Eiji;  Sato, Taka-Aki;  Maruyama, Takashi;  Miyoshi, Hiroyuki;  Taketo, Makoto Mark;  Oishi, Jun;  Inagaki, Ryosaku;  Ueda, Yutaka;  Okamoto, Shinya;  Okajima, Hideaki;  Sakai, Yoshiharu;  Sakurai, Takaki;  Haga, Hironori;  Hirota, Seiichi;  Ikeuchi, Hiroki;  Nakase, Hiroshi;  Marusawa, Hiroyuki;  Chiba, Tsutomu;  Takeuchi, Osamu;  Miyano, Satoru;  Seno, Hiroshi;  Ogawa, Seishi
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/03