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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection 期刊论文
Science, 2021
作者:  Jennifer M. Dan;  Jose Mateus;  Yu Kato;  Kathryn M. Hastie;  Esther Dawen Yu;  Caterina E. Faliti;  Alba Grifoni;  Sydney I. Ramirez;  Sonya Haupt;  April Frazier;  Catherine Nakao;  Vamseedhar Rayaprolu;  Stephen A. Rawlings;  Bjoern Peters;  Florian Krammer;  Viviana Simon;  Erica Ollmann Saphire;  Davey M. Smith;  Daniela Weiskopf;  Alessandro Sette;  Shane Crotty
收藏  |  浏览/下载:14/0  |  提交时间:2021/02/17
Causes of slowing‐down seasonal CO2 amplitude at Mauna Loa 期刊论文
Global Change Biology, 2020
作者:  Kai Wang;  Yilong Wang;  Xuhui Wang;  Yue He;  Xiangyi Li;  Ralph F. Keeling;  Philippe Ciais;  Martin Heimann;  Shushi Peng;  Fré;  ;  ric Chevallier;  Pierre Friedlingstein;  Stephen Sitch;  Wolfgang Buermann;  Vivek K. Arora;  Vanessa Haverd;  Atul K. Jain;  Etsushi Kato;  Sebastian Lienert;  Danica Lombardozzi;  Julia E. M. S. Nabel;  Benjamin Poulter;  Nicolas Vuichard;  Andy Wiltshire;  Ning Zeng;  Dan Zhu;  Shilong Piao
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/22
Sample collection from asteroid (162173) Ryugu by Hayabusa2: Implications for surface evolution 期刊论文
Science, 2020
作者:  T. Morota;  S. Sugita;  Y. Cho;  M. Kanamaru;  E. Tatsumi;  N. Sakatani;  R. Honda;  N. Hirata;  H. Kikuchi;  M. Yamada;  Y. Yokota;  S. Kameda;  M. Matsuoka;  H. Sawada;  C. Honda;  T. Kouyama;  K. Ogawa;  H. Suzuki;  K. Yoshioka;  M. Hayakawa;  N. Hirata;  M. Hirabayashi;  H. Miyamoto;  T. Michikami;  T. Hiroi;  R. Hemmi;  O. S. Barnouin;  C. M. Ernst;  K. Kitazato;  T. Nakamura;  L. Riu;  H. Senshu;  H. Kobayashi;  S. Sasaki;  G. Komatsu;  N. Tanabe;  Y. Fujii;  T. Irie;  M. Suemitsu;  N. Takaki;  C. Sugimoto;  K. Yumoto;  M. Ishida;  H. Kato;  K. Moroi;  D. Domingue;  P. Michel;  C. Pilorget;  T. Iwata;  M. Abe;  M. Ohtake;  Y. Nakauchi;  K. Tsumura;  H. Yabuta;  Y. Ishihara;  R. Noguchi;  K. Matsumoto;  A. Miura;  N. Namiki;  S. Tachibana;  M. Arakawa;  H. Ikeda;  K. Wada;  T. Mizuno;  C. Hirose;  S. Hosoda;  O. Mori;  T. Shimada;  S. Soldini;  R. Tsukizaki;  H. Yano;  M. Ozaki;  H. Takeuchi;  Y. Yamamoto;  T. Okada;  Y. Shimaki;  K. Shirai;  Y. Iijima;  H. Noda;  S. Kikuchi;  T. Yamaguchi;  N. Ogawa;  G. Ono;  Y. Mimasu;  K. Yoshikawa;  T. Takahashi;  Y. Takei;  A. Fujii;  S. Nakazawa;  F. Terui;  S. Tanaka;  M. Yoshikawa;  T. Saiki;  S. Watanabe;  Y. Tsuda
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13
Increased control of vegetation on global terrestrial energy fluxes 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (4) : 356-+
作者:  Forzieri, Giovanni;  Miralles, Diego G.;  Ciais, Philippe;  Alkama, Ramdane;  Ryu, Youngryel;  Duveiller, Gregory;  Zhang, Ke;  Robertson, Eddy;  Kautz, Markus;  Martens, Brecht;  Jiang, Chongya;  Arneth, Almut;  Georgievski, Goran;  Li, Wei;  Ceccherini, Guido;  Anthoni, Peter;  Lawrence, Peter;  Wiltshire, Andy;  Pongratz, Julia;  Piao, Shilong;  Sitch, Stephen;  Goll, Daniel S.;  Arora, Vivek K.;  Lienert, Sebastian;  Lombardozzi, Danica;  Kato, Etsushi;  Nabel, Julia E. M. S.;  Tian, Hanqin;  Friedlingstein, Pierre;  Cescatti, Alessandro
收藏  |  浏览/下载:15/0  |  提交时间:2020/05/13
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms 期刊论文
NATURE, 2020, 579 (7800) : 609-+
作者:  Huang, Weijiao;  Masureel, Matthieu;  Qu, Qianhui;  Janetzko, John;  Inoue, Asuka;  Kato, Hideaki E.;  Robertson, Michael J.;  Nguyen, Khanh C.;  Glenn, Jeffrey S.;  Skiniotis, Georgios;  Kobilka, Brian K.
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus, synchronizing the physiology and behaviour of animals to the light-dark cycle(1-4). The two receptors are established drug targets for aligning circadian phase to this cycle in disorders of sleep(5,6) and depression(1-4,7-9). Despite their importance, few in vivo active MT1-selective ligands have been reported(2,8,10-12), hampering both the understanding of circadian biology and the development of targeted therapeutics. Here we docked more than 150 million virtual molecules to an MT1 crystal structure, prioritizing structural fit and chemical novelty. Of these compounds, 38 high-ranking molecules were synthesized and tested, revealing ligands with potencies ranging from 470 picomolar to 6 micromolar. Structure-based optimization led to two selective MT1 inverse agonists-which were topologically unrelated to previously explored chemotypes-that acted as inverse agonists in a mouse model of circadian re-entrainment. Notably, we found that these MT1-selective inverse agonists advanced the phase of the mouse circadian clock by 1.3-1.5 h when given at subjective dusk, an agonist-like effect that was eliminated in MT1- but not in MT2-knockout mice. This study illustrates the opportunities for modulating melatonin receptor biology through MT1-selective ligands and for the discovery of previously undescribed, in vivo active chemotypes from structure-based screens of diverse, ultralarge libraries. A computational screen of an ultra-large virtual library against the structure of the melatonin receptor found nanomolar ligands, and ultimately two selective MT1 inverse agonists that induced phase advancement of the mouse circadian clock when given at subjective dusk.


  
End coronavirus stigma now 期刊论文
NATURE, 2020, 580 (7802) : 165-165
作者:  Tanaka, Yoshiki;  Hipolito, Christopher J.;  Maturana, Andres D.;  Ito, Koichi;  Kuroda, Teruo;  Higuchi, Takashi;  Katoh, Takayuki;  Kato, Hideaki E.;  Hattori, Motoyuki;  Kumazaki, Kaoru;  Tsukazaki, Tomoya;  Ishitani, Ryuichiro;  Suga, Hiroaki;  Nureki, Osamu
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

The pandemic is fuelling deplorable racism and discrimination, especially against Asian people. Education and research will also pay the price.


The pandemic is fuelling deplorable racism and discrimination, especially against Asian people. Education and research will also pay the price.


  
Caveolae in CNS arterioles mediate neurovascular coupling 期刊论文
NATURE, 2020
作者:  Huang, Weijiao;  Masureel, Matthieu;  Qu, Qianhui;  Janetzko, John;  Inoue, Asuka;  Kato, Hideaki E.;  Robertson, Michael J.;  Nguyen, Khanh C.;  Glenn, Jeffrey S.;  Skiniotis, Georgios;  Kobilka, Brian K.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

Caveolae in arteriolar endothelial cells-but not those in neighbouring smooth muscle cells-have a key role in neurovascular coupling, an essential function for meeting acute brain energy demand.


Proper brain function depends on neurovascular coupling: neural activity rapidly increases local blood flow to meet moment-to-moment changes in regional brain energy demand(1). Neurovascular coupling is the basis for functional brain imaging(2), and impaired neurovascular coupling is implicated in neurodegeneration(1). The underlying molecular and cellular mechanisms of neurovascular coupling remain poorly understood. The conventional view is that neurons or astrocytes release vasodilatory factors that act directly on smooth muscle cells (SMCs) to induce arterial dilation and increase local blood flow(1). Here, using two-photon microscopy to image neural activity and vascular dynamics simultaneously in the barrel cortex of awake mice under whisker stimulation, we found that arteriolar endothelial cells (aECs) have an active role in mediating neurovascular coupling. We found that aECs, unlike other vascular segments of endothelial cells in the central nervous system, have abundant caveolae. Acute genetic perturbations that eliminated caveolae in aECs, but not in neighbouring SMCs, impaired neurovascular coupling. Notably, caveolae function in aECs is independent of the endothelial NO synthase (eNOS)-mediated NO pathway. Ablation of both caveolae and eNOS completely abolished neurovascular coupling, whereas the single mutants exhibited partial impairment, revealing that the caveolae-mediated pathway in aECs is a major contributor to neurovascular coupling. Our findings indicate that vasodilation is largely mediated by endothelial cells that actively relay signals from the central nervous system to SMCs via a caveolae-dependent pathway.


  
Contrasting effects of CO2 fertilization, land-use change and warming on seasonal amplitude of Northern Hemisphere CO2 exchange 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (19) : 12361-12375
作者:  Bastos, Ana;  Ciais, Philippe;  Chevallier, Frederic;  Roedenbeck, Christian;  Ballantyne, Ashley P.;  Maignan, Fabienne;  Yin, Yi;  Fernandez-Martinez, Marcos;  Friedlingstein, Pierre;  Penuelas, Josep;  Piao, Shilong L.;  Sitch, Stephen;  Smith, William K.;  Wang, Xuhui;  Zhu, Zaichun;  Haverd, Vanessa;  Kato, Etsushi;  Jain, Atul K.;  Lienert, Sebastian;  Lombardozzi, Danica;  Nabel, Julia E. M. S.;  Peylin, Philippe;  Poulter, Benjamin;  Zhu, Dan
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Cortical layer-specific critical dynamics triggering perception 期刊论文
SCIENCE, 2019, 365 (6453) : 558-+
作者:  Marshel, James H.;  Kim, Yoon Seok;  Machado, Timothy A.;  Quirin, Sean;  Benson, Brandon;  Kadmon, Jonathan;  Raja, Cephra;  Chibukhchyan, Adelaida;  Ramakrishnan, Charu;  Inoue, Masatoshi;  Shane, Janelle C.;  McKnight, Douglas J.;  Yoshizawa, Susumu;  Kato, Hideaki E.;  Ganguli, Surya;  Deisseroth, Karl
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Radiative Heating Rates Computed With Clouds Derived From Satellite-Based Passive and Active Sensors and their Effects on Generation of Available Potential Energy 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (3) : 1720-1740
作者:  Kato, Seiji;  Rose, Fred G.;  Ham, Seung Hee;  Rutan, David A.;  Radkevich, Alexander;  Caldwell, Thomas E.;  Sun-Mack, Sunny;  Miller, Walter F.;  Chen, Yan
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
heating rate  radiation  clouds  available potential energy