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Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow 期刊论文
Science, 2021
作者:  H.E.S.S. Collaboration;  H. Abdalla;  F. Aharonian;  F. Ait Benkhali;  E. O. Angüner;  C. Arcaro;  C. Armand;  T. Armstrong;  H. Ashkar;  M. Backes;  V. Baghmanyan;  V. Barbosa Martins;  A. Barnacka;  M. Barnard;  Y. Becherini;  D. Berge;  K. Bernlöhr;  B. Bi;  E. Bissaldi;  M. Böttcher;  C. Boisson;  J. Bolmont;  M. de Bony de Lavergne;  M. Breuhaus;  F. Brun;  P. Brun;  M. Bryan;  M. Büchele;  T. Bulik;  T. Bylund;  S. Caroff;  A. Carosi;  S. Casanova;  T. Chand;  S. Chandra;  A. Chen;  G. Cotter;  M. Curyło;  J. Damascene Mbarubucyeye;  I. D. Davids;  J. Davies;  C. Deil;  J. Devin;  L. Dirson;  A. Djannati-Ataï;  A. Dmytriiev;  A. Donath;  V. Doroshenko;  L. Dreyer;  C. Duffy;  J. Dyks;  K. Egberts;  F. Eichhorn;  S. Einecke;  G. Emery;  J.-P. Ernenwein;  K. Feijen;  S. Fegan;  A. Fiasson;  G. Fichet de Clairfontaine;  G. Fontaine;  S. Funk;  M. Füßling;  S. Gabici;  Y. A. Gallant;  G. Giavitto;  L. Giunti;  D. Glawion;  J. F. Glicenstein;  M.-H. Grondin;  J. Hahn;  M. Haupt;  G. Hermann;  J. A. Hinton;  W. Hofmann;  C. Hoischen;  T. L. Holch;  M. Holler;  M. Hörbe;  D. Horns;  D. Huber;  M. Jamrozy;  D. Jankowsky;  F. Jankowsky;  A. Jardin-Blicq;  V. Joshi;  I. Jung-Richardt;  E. Kasai;  M. A. Kastendieck;  K. Katarzyński;  U. Katz;  D. Khangulyan;  B. Khélifi;  S. Klepser;  W. Kluźniak;  Nu. Komin;  R. Konno;  K. Kosack;  D. Kostunin;  M. Kreter;  G. Lamanna;  A. Lemière;  M. Lemoine-Goumard;  J.-P. Lenain;  F. Leuschner;  C. Levy;  T. Lohse;  I. Lypova;  J. Mackey;  J. Majumdar;  D. Malyshev;  D. Malyshev;  V. Marandon;  P. Marchegiani;  A. Marcowith;  A. Mares;  G. Martí-Devesa;  R. Marx;  G. Maurin;  P. J. Meintjes;  M. Meyer;  A. Mitchell;  R. Moderski;  L. Mohrmann;  A. Montanari;  C. Moore;  P. Morris;  E. Moulin;  J. Muller;  T. Murach;  K. Nakashima;  A. Nayerhoda;  M. de Naurois;  H. Ndiyavala;  J. Niemiec;  L. Oakes;  P. O’Brien;  H. Odaka;  S. Ohm;  L. Olivera-Nieto;  E. de Ona Wilhelmi;  M. Ostrowski;  S. Panny;  M. Panter;  R. D. Parsons;  G. Peron;  B. Peyaud;  Q. Piel;  S. Pita;  V. Poireau;  A. Priyana Noel;  D. A. Prokhorov;  H. Prokoph;  G. Pühlhofer;  M. Punch;  A. Quirrenbach;  S. Raab;  R. Rauth;  P. Reichherzer;  A. Reimer;  O. Reimer;  Q. Remy;  M. Renaud;  F. Rieger;  L. Rinchiuso;  C. Romoli;  G. Rowell;  B. Rudak;  E. Ruiz-Velasco;  V. Sahakian;  S. Sailer;  H. Salzmann;  D. A. Sanchez;  A. Santangelo;  M. Sasaki;  M. Scalici;  J. Schäfer;  F. Schüssler;  H. M. Schutte;  U. Schwanke;  M. Seglar-Arroyo;  M. Senniappan;  A. S. Seyffert;  N. Shafi;  J. N. S. Shapopi;  K. Shiningayamwe;  R. Simoni;  A. Sinha;  H. Sol;  A. Specovius;  S. Spencer;  M. Spir-Jacob;  Ł. Stawarz;  L. Sun;  R. Steenkamp;  C. Stegmann;  S. Steinmassl;  C. Steppa;  T. Takahashi;  T. Tam;  T. Tavernier;  A. M. Taylor;  R. Terrier;  J. H. E. Thiersen;  D. Tiziani;  M. Tluczykont;  L. Tomankova;  M. Tsirou;  R. Tuffs;  Y. Uchiyama;  D. J. van der Walt;  C. van Eldik;  C. van Rensburg;  B. van Soelen;  G. Vasileiadis;  J. Veh;  C. Venter;  P. Vincent;  J. Vink;  H. J. Völk;  Z. Wadiasingh;  S. J. Wagner;  J. Watson;  F. Werner;  R. White;  A. Wierzcholska;  Yu Wun Wong;  A. Yusafzai;  M. Zacharias;  R. Zanin;  D. Zargaryan;  A. A. Zdziarski;  A. Zech;  S. J. Zhu;  J. Zorn;  S. Zouari;  N. Żywucka;  P. Evans;  K. Page
收藏  |  浏览/下载：29/0  |  提交时间：2021/06/15
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9 期刊论文
NATURE, 2020, 581 (7808) : 316-+
作者:  Kokail, C.;  Maier, C.;  van Bijnen, R.;  Brydges, T.;  Joshi, M. K.;  Jurcevic, P.;  Muschik, C. A.;  Silvi, P.;  Blatt, R.;  Roos, C. F.;  Zoller, P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/03

The interaction between TASL and SLC15A4 links endolysosomal Toll-like receptors to the transcription factor IRF5, providing a mechanistic explanation for the involvement of the complex in systemic lupus erythematosus.


Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses(1-3). Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus(4,5)-interacts with the endolysosomal transporter SLC15A4, an essential but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune disease(4,6-9). Loss of this type-I-interferon-inducible protein, which we refer to as '  TLR adaptor interacting with SLC15A4 on the lysosome'  (TASL), abrogated responses to endolysosomal TLR agonists in both primary and transformed human immune cells. Deletion of SLC15A4 or TASL specifically impaired the activation of the IRF pathway without affecting NF-kappa B and MAPK signalling, which indicates that ligand recognition and TLR engagement in the endolysosome occurred normally. Extensive mutagenesis of TASL demonstrated that its localization and function relies on the interaction with SLC15A4. TASL contains a conserved pLxIS motif (in which p denotes a hydrophilic residue and x denotes any residue) that mediates the recruitment and activation of IRF5. This finding shows that TASL is an innate immune adaptor for TLR7, TLR8 and TLR9 signalling, revealing a clear mechanistic analogy with the IRF3 adaptors STING, MAVS and TRIF10,11. The identification of TASL as the component that links endolysosomal TLRs to the IRF5 transcription factor via SLC15A4 provides a mechanistic explanation for the involvement of these proteins in systemic lupus erythematosus(12-14).


  
Observed Emergence of the Climate Change Signal: From the Familiar to the Unknown 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (6)
作者:  Hawkins, E.;  Frame, D.;  Harrington, L.;  Joshi, M.;  King, A.;  Rojas, M.;  Sutton, R.
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/02
emergence  signal-to-noise  temperature  rainfall  observations  extremes  
Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data 期刊论文
NATURE GEOSCIENCE, 2020, 13 (3) : 213-+
作者:  Lognonne, P.;  Banerdt, W. B.;  Pike, W. T.;  Giardini, D.;  Christensen, U.;  Garcia, R. F.;  Kawamura, T.;  Kedar, S.;  Knapmeyer-Endrun, B.;  Margerin, L.;  Nimmo, F.;  Panning, M.;  Tauzin, B.;  Scholz, J. -R.;  Antonangeli, D.;  Barkaoui, S.;  Beucler, E.;  Bissig, F.;  Brinkman, N.;  Calvet, M.;  Ceylan, S.;  Charalambous, C.;  Davis, P.;  Van Driel, M.;  Drilleau, M.;  Fayon, L.;  Joshi, R.;  Kenda, B.;  Khan, A.;  Knapmeyer, M.;  Lekic, V.;  McClean, J.;  Mimoun, D.;  Murdoch, N.;  Pan, L.;  Perrin, C.;  Pinot, B.;  Pou, L.;  Menina, S.;  Rodriguez, S.;  Schmelzbach, C.;  Schmerr, N.;  Sollberger, D.;  Spiga, A.;  Staehler, S.;  Stott, A.;  Stutzmann, E.;  Tharimena, S.;  Widmer-Schnidrig, R.;  Andersson, F.;  Ansan, V.;  Beghein, C.;  Boese, M.;  Bozdag, E.;  Clinton, J.;  Daubar, I.;  Delage, P.;  Fuji, N.;  Golombek, M.;  Grott, M.;  Horleston, A.;  Hurst, K.;  Irving, J.;  Jacob, A.;  Knollenberg, J.;  Krasner, S.;  Krause, C.;  Lorenz, R.;  Michaut, C.;  Myhill, R.;  Nissen-Meyer, T.;  Ten Pierick, J.;  Plesa, A. -C.;  Quantin-Nataf, C.;  Robertsson, J.;  Rochas, L.;  Schimmel, M.;  Smrekar, S.;  Spohn, T.;  Teanby, N.;  Tromp, J.;  Vallade, J.;  Verdier, N.;  Vrettos, C.;  Weber, R.;  Banfield, D.;  Barrett, E.;  Bierwirth, M.;  Calcutt, S.;  Compaire, N.;  Johnson, C. L.;  Mance, D.;  Euchner, F.;  Kerjean, L.;  Mainsant, G.;  Mocquet, A.;  Rodriguez Manfredi, J. A.;  Pont, G.;  Laudet, P.;  Nebut, T.;  De Raucourt, S.;  Robert, O.;  Russell, C. T.;  Sylvestre-Baron, A.;  Tillier, S.;  Warren, T.;  Wieczorek, M.;  Yana, C.;  Zweifel, P.
收藏  |  浏览/下载：20/0  |  提交时间：2020/05/13
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Wilson, Mike R.;  Reske, Jake J.;  Holladay, Jeanne;  Wilber, Genna E.;  Rhodes, Mary;  Koeman, Julie;  Adams, Marie;  Johnson, Ben;  Su, Ren-Wei;  Joshi, Niraj R.;  Patterson, Amanda L.;  Shen, Hui;  Leach, Richard E.;  Teixeira, Jose M.;  Fazleabas, Asgerally T.;  Chandler, Ronald L.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Extended gamma-ray sources around pulsars constrain the origin of the positron flux at Earth 期刊论文
SCIENCE, 2017, 358 (6365) : 911-914
作者:  Abeysekara, A. U.;  Albert, A.;  Alfaro, R.;  Alvarez, C.;  Alvarez, J. D.;  Arceo, R.;  Arteaga-Velazquez, J. C.;  Rojas, D. Avila;  Solares, H. A. Ayala;  Barber, A. S.;  Bautista-Elivar, N.;  Becerril, A.;  Belmont-Moreno, E.;  BenZvi, S. Y.;  Berley, D.;  Bernal, A.;  Braun, J.;  Brisbois, C.;  Caballero-Mora, K. S.;  Capistran, T.;  Carraminana, A.;  Casanova, S.;  Castillo, M.;  Cotti, U.;  Cotzomi, J.;  de Leon, S. Coutino;  De Leon, C.;  De la Fuente, E.;  Dingus, B. L.;  DuVernois, M. A.;  Diaz-Velez, J. C.;  Ellsworth, R. W.;  Engel, K.;  Enriquez-Rivera, O.;  Fiorino, D. W.;  Fraija, N.;  Garcia-Gonzalez, J. A.;  Garfias, F.;  Gerhardt, M.;  Munoz, A. Gonzalez;  Gonzalez, M. M.;  Goodman, J. A.;  Hampel-Arias, Z.;  Harding, J. P.;  Hernandez, S.;  Hernandez-Almada, A.;  Hinton, J.;  Hona, B.;  Hui, C. M.;  Huntemeyer, P.;  Iriarte, A.;  Jardin-Blicq, A.;  Joshi, V.;  Kaufmann, S.;  Kieda, D.;  Lara, A.;  Lauer, R. J.;  Lee, W. H.;  Lennarz, D.;  Vargas, H. Leon;  Linnemann, J. T.;  Longinotti, A. L.;  Raya, G. Luis;  Luna-Garcia, R.;  Lopez-Coto, R.;  Malone, K.;  Marinelli, S. S.;  Martinez, O.;  Martinez-Castellanos, I.;  Martinez-Castro, J.;  Martinez-Huerta, H.;  Matthews, J. A.;  Miranda-Romagnoli, P.;  Moreno, E.;  Mostafa, M.;  Nellen, L.;  Newbold, M.;  Nisa, M. U.;  Noriega-Papaqui, R.;  Pelayo, R.;  Pretz, J.;  Perez-Perez, E. G.;  Ren, Z.;  Rho, C. D.;  Riviere, C.;  Rosa-Gonzalez, D.;  Rosenberg, M.;  Ruiz-Velasco, E.;  Salazar, H.;  Greus, F. Salesa;  Sandoval, A.;  Schneider, M.;  Schoorlemmer, H.;  Sinnis, G.;  Smith, A. J.;  Springer, R. W.;  Surajbali, P.;  Taboada, I.;  Tibolla, O.;  Tollefson, K.;  Torres, I.;  Ukwatta, T. N.;  Vianello, G.;  Weisgarber, T.;  Westerhoff, S.;  Wisher, I. G.;  Wood, J.;  Yapici, T.;  Yodh, G.;  Younk, P. W.;  Zepeda, A.;  Zhou, H.;  Guo, F.;  Hahn, J.;  Li, H.;  Zhang, H.
收藏  |  浏览/下载：25/0  |  提交时间：2019/11/27
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Joshi, Peter K.;  Pirastu, Nicola;  Kentistou, Katherine A.;  Fischer, Krista;  Hofer, Edith;  Schraut, Katharina E.;  Clark, David W.;  Nutile, Teresa;  Barnes, Catriona L. K.;  Timmers, Paul R. H. J.;  Shen, Xia;  Gandin, Ilaria;  McDaid, Aaron F.;  Hansen, Thomas Folkmann;  Gordon, Scott D.;  Giulianini, Franco;  Boutin, Thibaud S.;  Abdellaoui, Abdel;  Zhao, Wei;  Medina-Gomez, Carolina;  Bartz, Traci M.;  Trompet, Stella;  Lange, Leslie A.;  Raffield, Laura;  van der Spek, Ashley;  Galesloot, Tessel E.;  Proitsi, Petroula;  Yanek, Lisa R.;  Bielak, Lawrence F.;  Payton, Antony;  Murgia, Federico;  Concas, Maria Pina;  Biino, Ginevra;  Tajuddin, Salman M.;  Seppala, Ilkka;  Amin, Najaf;  Boerwinkle, Eric;  Borglum, Anders D.;  Campbell, Archie;  Demerath, Ellen W.;  Demuth, Ilja;  Faul, Jessica D.;  Ford, Ian;  Gialluisi, Alessandro;  Gogele, Martin;  Graff, MariaElisa;  Hingorani, Aroon;  Hottenga, Jouke-Jan;  Hougaard, David M.;  Hurme, Mikko A.;  Ikram, M. Arfan;  Jylha, Marja;  Kuh, Diana;  Ligthart, Lannie;  Lill, Christina M.;  Lindenberger, Ulman;  Lumley, Thomas;  Magi, Reedik;  Marques-Vidal, Pedro;  Medland, Sarah E.;  Milani, Lili;  Nagy, Reka;  Ollier, William E. R.;  Peyser, Patricia A.;  Pramstaller, Peter P.;  Ridker, Paul M.;  Rivadeneira, Fernando;  Ruggiero, Daniela;  Saba, Yasaman;  Schmidt, Reinhold;  Schmidt, Helena;  Slagboom, P. Eline;  Smith, Blair H.;  Smith, Jennifer A.;  Sotoodehnia, Nona;  Steinhagen-Thiessen, Elisabeth;  van Rooij, Frank J. A.;  Verbeek, Andre L.;  Vermeulen, Sita H.;  Vollenweider, Peter;  Wang, Yunpeng;  Werge, Thomas;  Whitfield, John B.;  Zonderman, Alan B.;  Lehtimaki, Terho;  Evans, Michele K.;  Pirastu, Mario;  Fuchsberger, Christian;  Bertram, Lars;  Pendleton, Neil;  Kardia, Sharon L. R.;  Ciullo, Marina;  Becker, Diane M.;  Wong, Andrew;  Psaty, Bruce M.;  van Duijn, Cornelia M.;  Wilson, James G.;  Jukema, J. Wouter;  Kiemeney, Lambertus;  Uitterlinden, Andre G.;  Franceschini, Nora;  North, Kari E.;  Weir, David R.;  Metspalu, Andres;  Boomsma, Dorret I.;  Hayward, Caroline;  Chasman, Daniel;  Martin, Nicholas G.;  Sattar, Naveed;  Campbell, Harry;  Esko, Tonu;  Kutalik, Zoltan;  Wilson, James F.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Anomalous convective activity over sub-tropical east Pacific during 2015 and associated boreal summer monsoon teleconnections 期刊论文
CLIMATE DYNAMICS, 2017, 48 (11)
作者:  Mujumdar, Milind;  Sooraj, K. P.;  Krishnan, R.;  Preethi, B.;  Joshi, Manish K.;  Varikoden, Hamza;  Singh, Bhupendra B.;  Rajeevan, M.
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
East Pacific storms  Sub-tropical east-west asymmetry  Meridional SST gradient  Pacific-monsoon teleconnection