Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

doi:10.1038/s41467-018-05104-9

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-018-05104-9
	Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
	Joshi, Peter K.1; Pirastu, Nicola 1; Kentistou, Katherine A.1,2; Fischer, Krista 3; Hofer, Edith 4,5; Schraut, Katharina E.1,2; Clark, David W.1; Nutile, Teresa 6; Barnes, Catriona L. K.1; Timmers, Paul R. H. J.1; Shen, Xia 1,7; Gandin, Ilaria 8,9; McDaid, Aaron F.10,11; Hansen, Thomas Folkmann 12,13; Gordon, Scott D.14; Giulianini, Franco 15; Boutin, Thibaud S.16; Abdellaoui, Abdel 17; Zhao, Wei 18; Medina-Gomez, Carolina 19,20; Bartz, Traci M.21,22; Trompet, Stella 23,24; Lange, Leslie A.25; Raffield, Laura 26; van der Spek, Ashley 20; Galesloot, Tessel E.27; Proitsi, Petroula 28; Yanek, Lisa R.29; Bielak, Lawrence F.18; Payton, Antony 30; Murgia, Federico 31,32; Concas, Maria Pina 33; Biino, Ginevra 34; Tajuddin, Salman M.35; Seppala, Ilkka 36,37; Amin, Najaf 20; Boerwinkle, Eric 38; Borglum, Anders D.13,39,40; Campbell, Archie 41; Demerath, Ellen W.42; Demuth, Ilja 43,44,45; Faul, Jessica D.46; Ford, Ian 47; Gialluisi, Alessandro 48; Gogele, Martin 31,32; Graff, MariaElisa 49; Hingorani, Aroon 50; Hottenga, Jouke-Jan 17; Hougaard, David M.13,51; Hurme, Mikko A.37,52; Ikram, M. Arfan 20; Jylha, Marja 53; Kuh, Diana 28; Ligthart, Lannie 17; Lill, Christina M.54; Lindenberger, Ulman 55,56; Lumley, Thomas 57; Magi, Reedik 3; Marques-Vidal, Pedro 58; Medland, Sarah E.14; Milani, Lili 3; Nagy, Reka 16; Ollier, William E. R.59; Peyser, Patricia A.18; Pramstaller, Peter P.31,32; Ridker, Paul M.15,60; Rivadeneira, Fernando 19,20; Ruggiero, Daniela 6; Saba, Yasaman 61; Schmidt, Reinhold 4; Schmidt, Helena 61; Slagboom, P. Eline 62; Smith, Blair H.63; Smith, Jennifer A.18,46; Sotoodehnia, Nona 64; Steinhagen-Thiessen, Elisabeth 43; van Rooij, Frank J. A.20; Verbeek, Andre L.27; Vermeulen, Sita H.27; Vollenweider, Peter 58; Wang, Yunpeng 13,65; Werge, Thomas 12,13; Whitfield, John B.14; Zonderman, Alan B.35; Lehtimaki, Terho 36,37; Evans, Michele K.35; Pirastu, Mario 33; Fuchsberger, Christian 31,32; Bertram, Lars 66,67; Pendleton, Neil 68; Kardia, Sharon L. R.18; Ciullo, Marina 6,48; Becker, Diane M.29; Wong, Andrew 28; Psaty, Bruce M.22,69,70,71; van Duijn, Cornelia M.20; Wilson, James G.72; Jukema, J. Wouter 24; Kiemeney, Lambertus 27; Uitterlinden, Andre G.19,20; Franceschini, Nora 49; North, Kari E.49; Weir, David R.46; Metspalu, Andres 3; Boomsma, Dorret I.17; Hayward, Caroline 16; Chasman, Daniel 15,60; Martin, Nicholas G.14; Sattar, Naveed 73; Campbell, Harry 1; Esko, Tonu 3,74; Kutalik, Zoltan 10,11; Wilson, James F.1,16
	2017-10-13
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	Scotland; Estonia; Austria; Italy; Sweden; Switzerland; Denmark; Australia; USA; Netherlands; England; Germany; Finland; New Zealand; Norway
英文摘要	Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000412871300006
WOS关键词	SUSCEPTIBILITY LOCI ; GENETIC-VARIANTS ; BLOOD-PRESSURE ; SURVIVAL ; RISK ; AGE ; POPULATION ; DISEASE ; INDIVIDUALS ; APOE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203894
专题	资源环境科学
作者单位	1.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland; 2.Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland; 3.Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia; 4.Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, A-8036 Graz, Austria; 5.Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria; 6.Inst Genet & Biophys A Buzzati Traverso, CNR, I-80131 Naples, Italy; 7.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden; 8.Univ Trieste, Dept Med Sci, I-34100 Trieste, Italy; 9.IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy; 10.Lausanne Univ Hosp, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland; 11.Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland; 12.Mental Hlth Ctr Sct Hans, Mental Hlth Serv Copenhagen, Inst Biol Psychiat, DK-4000 Roskilde, Denmark; 13.Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, DK-8000 Aarhus, Denmark; 14.QIMR Berghofer Inst Med Res, Brisbane, Qld 4006, Australia; 15.Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA; 16.Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland; 17.Vrije Univ Amsterdam, Amsterdam Publ Hlth Inst APH, Dept Biol Psychol, Netherlands Twin Register, NL-1081BT Amsterdam, Netherlands; 18.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA; 19.Erasmus Univ, Med Ctr, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands; 20.Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3015 Rotterdam, Netherlands; 21.Univ Washington, Cardiovasc Hlth Res Unit, Dept Biostat, Seattle, WA 98101 USA; 22.Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98101 USA; 23.Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, NL-2300RC Leiden, Netherlands; 24.Leiden Univ, Med Ctr, Dept Cardiol, NL-2300RC Leiden, Netherlands; 25.Univ Colorado Denver, Anschutz Med Campus, Dept Med, Aurora, CO 80045 USA; 26.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA; 27.Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6500 HB Nijmegen, Netherlands; 28.UCL, MRC Unit Lifelong Hlth & Ageing UCL, London WC1B 5JU, England; 29.Johns Hopkins Univ, Sch Med, GeneSTAR Res Program, Dept Med, Baltimore, MD 21287 USA; 30.Univ Manchester, Ctr Epidemiol, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester M13 9PL, Lancs, England; 31.European Acad Bozen Bolzano EURAC, Ctr Biomed, I-39100 Bolzano, Italy; 32.Univ Lubeck, Affiliated Inst, Lubeck, Germany; 33.Natl Res Council Italy, Inst Genet & Biomed Res Support Unity, I-07100 Sassari, Italy; 34.Natl Res Council Italy, Inst Mol Genet, I-27100 Pavia, Italy; 35.NIA, NIH, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA; 36.Univ Tampere, Fimlab Lab, Dept Clin Chem, Tampere 33014, Finland; 37.Univ Tampere, Fac Med & Life Sci, Tampere 33014, Finland; 38.Univ Texas Houston, Hlth Sci Ctr Houston, UTHlth Sch Publ, Houston, TX 77030 USA; 39.Aarhus Univ, Dept Biomed Human Genet, DK-8000 Aarhus, Denmark; 40.Aarhus Univ, Ctr Integrat Sequencing, iSEQ, DK-8000 Aarhus, Denmark; 41.Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland; 42.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA; 43.Univ Med Berlin, Res Grp Geriatr, Charite, D-13347 Berlin, Germany; 44.Univ Med Berlin, Interdisciplinary Metab Ctr, Lipid Clin, Charite, D-13353 Berlin, Germany; 45.Univ Med Berlin, Inst Med & Human Genet, Charite, D-13353 Berlin, Germany; 46.Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48014 USA; 47.Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland; 48.IRCCS Neuromed, I-86077 Pozzilli, IS, Italy; 49.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA; 50.UCL, Inst Cardiovasc Sci, London WC1E 6BT, England; 51.Statens Serum Inst, Ctr Neonatal Screening, Dept Congenital Disorders, DK-2300 Copenhagen, Denmark; 52.Univ Tampere, Fimlab Lab, Dept Microbiol & Immunol, Tampere 33014, Finland; 53.Univ Tampere, Fac Social Sci, Gerontol Res Ctr, Tampere 33104, Finland; 54.Univ Lubeck, Inst Neurogenet, Genet & Mol Epidemiol Grp, D-23562 Lubeck, Germany; 55.Max Planck Inst Human Dev, Ctr Lifespan Psychol, D-14195 Berlin, Germany; 56.Max Planck UCL Ctr Computat Psychiat & Ageing Res, D-14195 Berlin, Germany; 57.Univ Auckland, Dept Stat, Auckland 1010, New Zealand; 58.Lausanne Univ Hosp, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland; 59.Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Hlth Sci, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester M13 9PL, Lancs, England; 60.Harvard Med Sch, TH Chan Sch Publ Hlth, Boston, MA 02115 USA; 61.Med Univ Graz, Austrian Stroke Prevent Study, Inst Mol Biol & Biochem, Ctr Mol Med, A-8010 Graz, Austria; 62.Leiden Univ, Med Ctr, Sec Mol Epidemiol, Dept Med Stat, NL-2300RC Leiden, Netherlands; 63.Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee DD1 9SY, Scotland; 64.Univ Washington, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA; 65.Univ Oslo, NORMENT, KG Jebsen Ctr Psychosis Res, Inst Clin Med, N-0450 Oslo, Norway; 66.Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt, Inst Neurogenet & Cardiogenet, D-23562 Lubeck, Germany; 67.Imperial Coll, Sch Publ Hlth, Neuroepidemiol & Ageing Res Grp, London W6 8RP, England; 68.Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Biol Sci, Div Neurosci & Expt Psychol, Manchester M13 9PL, Greater Manches, England; 69.Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98101 USA; 70.Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98101 USA; 71.Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA; 72.Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA; 73.Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TD, Lanark, Scotland; 74.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA
推荐引用方式 GB/T 7714	Joshi, Peter K.,Pirastu, Nicola,Kentistou, Katherine A.,et al. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity[J]. NATURE COMMUNICATIONS,2017,8.
APA	Joshi, Peter K..,Pirastu, Nicola.,Kentistou, Katherine A..,Fischer, Krista.,Hofer, Edith.,...&Wilson, James F..(2017).Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.NATURE COMMUNICATIONS,8.
MLA	Joshi, Peter K.,et al."Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity".NATURE COMMUNICATIONS 8(2017).