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Cholangiocyte organoids can repair bile ducts after transplantation in the human liver 期刊论文
Science, 2021
作者:  Fotios Sampaziotis;  Daniele Muraro;  Olivia C. Tysoe;  Stephen Sawiak;  Timothy E. Beach;  Edmund M. Godfrey;  Sara S. Upponi;  Teresa Brevini;  Brandon T. Wesley;  Jose Garcia-Bernardo;  Krishnaa Mahbubani;  Giovanni Canu;  Richard Gieseck;  Natalie L. Berntsen;  Victoria L. Mulcahy;  Keziah Crick;  Corrina Fear;  Sharayne Robinson;  Lisa Swift;  Laure Gambardella;  Johannes Bargehr;  Daniel Ortmann;  Stephanie E. Brown;  Anna Osnato;  Michael P. Murphy;  Gareth Corbett;  William T. H. Gelson;  George F. Mells;  Peter Humphreys;  Susan E. Davies;  Irum Amin;  Paul Gibbs;  Sanjay Sinha;  Sarah A. Teichmann;  Andrew J. Butler;  Teik Choon See;  Espen Melum;  Christopher J. E. Watson;  Kourosh Saeb-Parsy;  Ludovic Vallier
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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events 期刊论文
Science, 2021
作者:  Jacob E. Lemieux;  Katherine J. Siddle;  Bennett M. Shaw;  Christine Loreth;  Stephen F. Schaffner;  Adrianne Gladden-Young;  Gordon Adams;  Timelia Fink;  Christopher H. Tomkins-Tinch;  Lydia A. Krasilnikova;  Katherine C. DeRuff;  Melissa Rudy;  Matthew R. Bauer;  Kim A. Lagerborg;  Erica Normandin;  Sinéad B. Chapman;  Steven K. Reilly;  Melis N. Anahtar;  Aaron E. Lin;  Amber Carter;  Cameron Myhrvold;  Molly E. Kemball;  Sushma Chaluvadi;  Caroline Cusick;  Katelyn Flowers;  Anna Neumann;  Felecia Cerrato;  Maha Farhat;  Damien Slater;  Jason B. Harris;  John A. Branda;  David Hooper;  Jessie M. Gaeta;  Travis P. Baggett;  James O’Connell;  Andreas Gnirke;  Tami D. Lieberman;  Anthony Philippakis;  Meagan Burns;  Catherine M. Brown;  Jeremy Luban;  Edward T. Ryan;  Sarah E. Turbett;  Regina C. LaRocque;  William P. Hanage;  Glen R. Gallagher;  Lawrence C. Madoff;  Sandra Smole;  Virginia M. Pierce;  Eric Rosenberg;  Pardis C. Sabeti;  Daniel J. Park;  Bronwyn L. MacInnis
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Ecological insights from three decades of animal movement tracking across a changing Arctic 期刊论文
Science, 2020
作者:  Sarah C. Davidson;  Gil Bohrer;  Eliezer Gurarie;  Scott LaPoint;  Peter J. Mahoney;  Natalie T. Boelman;  Jan U. H. Eitel;  Laura R. Prugh;  Lee A. Vierling;  Jyoti Jennewein;  Emma Grier;  Ophélie Couriot;  Allicia P. Kelly;  Arjan J. H. Meddens;  Ruth Y. Oliver;  Roland Kays;  Martin Wikelski;  Tomas Aarvak;  Joshua T. Ackerman;  José A. Alves;  Erin Bayne;  Bryan Bedrosian;  Jerrold L. Belant;  Andrew M. Berdahl;  Alicia M. Berlin;  Dominique Berteaux;  Joël Bêty;  Dmitrijs Boiko;  Travis L. Booms;  Bridget L. Borg;  Stan Boutin;  W. Sean Boyd;  Kane Brides;  Stephen Brown;  Victor N. Bulyuk;  Kurt K. Burnham;  David Cabot;  Michael Casazza;  Katherine Christie;  Erica H. Craig;  Shanti E. Davis;  Tracy Davison;  Dominic Demma;  Christopher R. DeSorbo;  Andrew Dixon;  Robert Domenech;  Götz Eichhorn;  Kyle Elliott;  Joseph R. Evenson;  Klaus-Michael Exo;  Steven H. Ferguson;  Wolfgang Fiedler;  Aaron Fisk;  Jérôme Fort;  Alastair Franke;  Mark R. Fuller;  Stefan Garthe;  Gilles Gauthier;  Grant Gilchrist;  Petr Glazov;  Carrie E. Gray;  David Grémillet;  Larry Griffin;  Michael T. Hallworth;  Autumn-Lynn Harrison;  Holly L. Hennin;  J. Mark Hipfner;  James Hodson;  James A. Johnson;  Kyle Joly;  Kimberly Jones;  Todd E. Katzner;  Jeff W. Kidd;  Elly C. Knight;  Michael N. Kochert;  Andrea Kölzsch;  Helmut Kruckenberg;  Benjamin J. Lagassé;  Sandra Lai;  Jean-François Lamarre;  Richard B. Lanctot;  Nicholas C. Larter;  A. David M. Latham;  Christopher J. Latty;  James P. Lawler;  Don-Jean Léandri-Breton;  Hansoo Lee;  Stephen B. Lewis;  Oliver P. Love;  Jesper Madsen;  Mark Maftei;  Mark L. Mallory;  Buck Mangipane;  Mikhail Y. Markovets;  Peter P. Marra;  Rebecca McGuire;  Carol L. McIntyre;  Emily A. McKinnon;  Tricia A. Miller;  Sander Moonen;  Tong Mu;  Gerhard J. D. M. Müskens;  Janet Ng;  Kerry L. Nicholson;  Ingar Jostein Øien;  Cory Overton;  Patricia A. Owen;  Allison Patterson;  Aevar Petersen;  Ivan Pokrovsky;  Luke L. Powell;  Rui Prieto;  Petra Quillfeldt;  Jennie Rausch;  Kelsey Russell;  Sarah T. Saalfeld;  Hans Schekkerman;  Joel A. Schmutz;  Philipp Schwemmer;  Dale R. Seip;  Adam Shreading;  Mónica A. Silva;  Brian W. Smith;  Fletcher Smith;  Jeff P. Smith;  Katherine R. S. Snell;  Aleksandr Sokolov;  Vasiliy Sokolov;  Diana V Solovyeva;  Mathew S. Sorum;  Grigori Tertitski;  J. F. Therrien;  Kasper Thorup;  T. Lee Tibbitts;  Ingrid Tulp;  Brian D. Uher-Koch;  Rob S. A. van Bemmelen;  Steven Van Wilgenburg;  Andrew L. Von Duyke;  Jesse L. Watson;  Bryan D. Watts;  Judy A. Williams;  Matthew T. Wilson;  James R. Wright;  Michael A. Yates;  David J. Yurkowski;  Ramūnas Žydelis;  Mark Hebblewhite
收藏  |  浏览/下载:19/0  |  提交时间:2020/11/09
Cell type–specific genetic regulation of gene expression across human tissues 期刊论文
Science, 2020
作者:  Sarah Kim-Hellmuth;  François Aguet;  Meritxell Oliva;  Manuel Muñoz-Aguirre;  Silva Kasela;  Valentin Wucher;  Stephane E. Castel;  Andrew R. Hamel;  Ana Viñuela;  Amy L. Roberts;  Serghei Mangul;  Xiaoquan Wen;  Gao Wang;  Alvaro N. Barbeira;  Diego Garrido-Martín;  Brian B. Nadel;  Yuxin Zou;  Rodrigo Bonazzola;  Jie Quan;  Andrew Brown;  Angel Martinez-Perez;  José Manuel Soria;  GTEx Consortium§;  Gad Getz;  Emmanouil T. Dermitzakis;  Kerrin S. Small;  Matthew Stephens;  Hualin S. Xi;  Hae Kyung Im;  Roderic Guigó;  Ayellet V. Segrè;  Barbara E. Stranger;  Kristin G. Ardlie;  Tuuli Lappalainen
收藏  |  浏览/下载:12/0  |  提交时间:2020/09/14
The impact of sex on gene expression across human tissues 期刊论文
Science, 2020
作者:  Meritxell Oliva;  Manuel Muñoz-Aguirre;  Sarah Kim-Hellmuth;  Valentin Wucher;  Ariel D. H. Gewirtz;  Daniel J. Cotter;  Princy Parsana;  Silva Kasela;  Brunilda Balliu;  Ana Viñuela;  Stephane E. Castel;  Pejman Mohammadi;  François Aguet;  Yuxin Zou;  Ekaterina A. Khramtsova;  Andrew D. Skol;  Diego Garrido-Martín;  Ferran Reverter;  Andrew Brown;  Patrick Evans;  Eric R. Gamazon;  Anthony Payne;  Rodrigo Bonazzola;  Alvaro N. Barbeira;  Andrew R. Hamel;  Angel Martinez-Perez;  José Manuel Soria;  GTEx Consortium§;  Brandon L. Pierce;  Matthew Stephens;  Eleazar Eskin;  Emmanouil T. Dermitzakis;  Ayellet V. Segrè;  Hae Kyung Im;  Barbara E. Engelhardt;  Kristin G. Ardlie;  Stephen B. Montgomery;  Alexis J. Battle;  Tuuli Lappalainen;  Roderic Guigó;  Barbara E. Stranger
收藏  |  浏览/下载:14/0  |  提交时间:2020/09/14
SARS-CoV-2 infection protects against rechallenge in rhesus macaques 期刊论文
Science, 2020
作者:  Abishek Chandrashekar;  Jinyan Liu;  Amanda J. Martinot;  Katherine McMahan;  Noe B. Mercado;  Lauren Peter;  Lisa H. Tostanoski;  Jingyou Yu;  Zoltan Maliga;  Michael Nekorchuk;  Kathleen Busman-Sahay;  Margaret Terry;  Linda M. Wrijil;  Sarah Ducat;  David R. Martinez;  Caroline Atyeo;  Stephanie Fischinger;  John S. Burke;  Matthew D. Slein;  Laurent Pessaint;  Alex Van Ry;  Jack Greenhouse;  Tammy Taylor;  Kelvin Blade;  Anthony Cook;  Brad Finneyfrock;  Renita Brown;  Elyse Teow;  Jason Velasco;  Roland Zahn;  Frank Wegmann;  Peter Abbink;  Esther A. Bondzie;  Gabriel Dagotto;  Makda S. Gebre;  Xuan He;  Catherine Jacob-Dolan;  Nicole Kordana;  Zhenfeng Li;  Michelle A. Lifton;  Shant H. Mahrokhian;  Lori F. Maxfield;  Ramya Nityanandam;  Joseph P. Nkolola;  Aaron G. Schmidt;  Andrew D. Miller;  Ralph S. Baric;  Galit Alter;  Peter K. Sorger;  Jacob D. Estes;  Hanne Andersen;  Mark G. Lewis;  Dan H. Barouch
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A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
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The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Analogies for a No-Analog World: Tackling Uncertainties in Reintroduction Planning 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2020, 35 (7) : 551-554
作者:  Forbes, Elizabeth S.;  Alagona, Peter S.;  Adams, Andrea J.;  Anderson, Sarah E.;  Brown, Kevin C.;  Colby, Jolie;  Cooper, Scott D.;  Denny, Sean M.;  Hiroyasu, Elizabeth H. T.;  Heilmayr, Robert;  Kendall, Bruce E.;  Martin, Jennifer A.;  Hardesty-Moore, Molly;  Mychajliw, Alexis M.;  Tyrrell, Brian P.;  Welch, Zoe S.
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Microbial processing of plant remains is co‐limited by multiple nutrients in global grasslands 期刊论文
Global Change Biology, 2020
作者:  Raú;  l Ochoa‐;  Hueso;  Elizabeth T. Borer;  Eric W. Seabloom;  Sarah E. Hobbie;  Anita C. Risch;  Scott L. Collins;  Juan Alberti;  ;  ctor A. Bahamonde;  Cynthia S. Brown;  Maria C. Caldeira;  Pedro Daleo;  Chris R. Dickman;  Anne Ebeling;  Nico Eisenhauer;  Ellen H. Esch;  Anu Eskelinen;  Victoria Ferná;  ndez;  Sabine Gü;  sewell;  Blanca Gutierrez‐;  Larruga;  Kirsten Hofmockel;  Ramesh Laungani;  Eric Lind;  Andrea Ló;  pez;  Rebecca L. McCulley;  Joslin L. Moore;  Pablo L. Peri;  Sally A. Power;  Jodi N. Price;  Suzanne M. Prober;  Christiane Roscher;  Judith M. Sarneel;  Martin Schü;  tz;  Julia Siebert;  Rachel J. Standish;  Sergio Velasco Ayuso;  Risto Virtanen;  Glenda M. Wardle;  Georg Wiehl;  Laura Yahdjian;  Tara Zamin
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Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
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