GSTDTAP

浏览/检索结果: 共74条,第1-10条 帮助

限定条件                
已选(0)清除 条数/页:   排序方式:
Distribution and stable carbon isotopic composition of dicarboxylic acids, ketocarboxylic acids and α-dicarbonyls in fresh and aged biomass burning aerosols 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Minxia Shen, Kin Fai Ho, Wenting Dai, Suixin Liu, Ting Zhang, Qiyuan Wang, Jingjing Meng, Judith C. Chow, John G. Watson, Junji Cao, and Jianjun Li
收藏  |  浏览/下载:11/0  |  提交时间:2022/06/24
A comprehensive quantification of global nitrous oxide sources and sinks 期刊论文
Nature, 2020
作者:  Hanqin Tian;  Rongting Xu;  Josep G. Canadell;  Rona L. Thompson;  Wilfried Winiwarter;  Parvadha Suntharalingam;  Eric A. Davidson;  Philippe Ciais;  Robert B. Jackson;  Greet Janssens-Maenhout;  Michael J. Prather;  Pierre Regnier;  Naiqing Pan;  Shufen Pan;  Glen P. Peters;  Hao Shi;  Francesco N. Tubiello;  ;  nke Zaehle;  Feng Zhou;  Almut Arneth;  Gianna Battaglia;  Sarah Berthet;  Laurent Bopp;  Alexander F. Bouwman;  Erik T. Buitenhuis;  Jinfeng Chang;  Martyn P. Chipperfield;  Shree R. S. Dangal;  Edward Dlugokencky;  James W. Elkins;  Bradley D. Eyre;  Bojie Fu;  Bradley Hall;  Akihiko Ito;  Fortunat Joos;  Paul B. Krummel;  Angela Landolfi;  Goulven G. Laruelle;  Ronny Lauerwald;  Wei Li;  Sebastian Lienert;  Taylor Maavara;  Michael MacLeod;  Dylan B. Millet;  Stefan Olin;  Prabir K. Patra;  Ronald G. Prinn;  Peter A. Raymond;  Daniel J. Ruiz;  Guido R. van der Werf;  Nicolas Vuichard;  Junjie Wang;  Ray F. Weiss;  Kelley C. Wells;  Chris Wilson;  Jia Yang;  Yuanzhi Yao
收藏  |  浏览/下载:24/0  |  提交时间:2020/10/12
Vulnerability of Antarctica鈥檚 ice shelves to meltwater-driven fracture 期刊论文
Nature, 2020
作者:  Ching-Yao Lai;  Jonathan Kingslake;  Martin G. Wearing;  Po-Hsuan Cameron Chen;  Pierre Gentine;  Harold Li;  Julian J. Spergel;  J. Melchior van Wessem
收藏  |  浏览/下载:13/0  |  提交时间:2020/09/08
New Guinea has the world鈥檚 richest island flora 期刊论文
Nature, 2020
作者:  Rodrigo Cá;  mara-Leret;  David G. Frodin;  Frits Adema;  Christiane Anderson;  Marc S. Appelhans;  George Argent;  Susana Arias Guerrero;  Peter Ashton;  William J. Baker;  Anders S. Barfod;  David Barrington;  Renata Borosova;  Gemma L. C. Bramley;  Marie Briggs;  Sven Buerki;  Daniel Cahen;  Martin W. Callmander;  Martin Cheek;  Cheng-Wei Chen;  Barry J. Conn;  Mark J. E. Coode;  Iain Darbyshire;  Sally Dawson;  John Dransfield;  Clare Drinkell;  Brigitta Duyfjes;  Atsushi Ebihara;  Zacky Ezedin;  Long-Fei Fu;  Osia Gideon;  Deden Girmansyah;  Rafaë;  l Govaerts;  Helen Fortune-Hopkins;  Gustavo Hassemer;  Alistair Hay;  Charlie D. Heatubun;  D. J. Nicholas Hind;  Peter Hoch;  Peter Homot;  Peter Hovenkamp;  Mark Hughes;  Matthew Jebb;  Laura Jennings;  Tiberius Jimbo;  Michael Kessler;  Ruth Kiew;  Sandra Knapp;  Penniel Lamei;  Marcus Lehnert;  Gwilym P. Lewis;  Hans Peter Linder;  Stuart Lindsay;  Yee Wen Low;  Eve Lucas;  Jeffrey P. Mancera;  Alexandre K. Monro;  Alison Moore;  David J. Middleton;  Hidetoshi Nagamasu;  Mark F. Newman;  Eimear Nic Lughadha;  Pablo H. A. Melo;  Daniel J. Ohlsen;  Caroline M. Pannell;  Barbara Parris;  Laura Pearce;  Darin S. Penneys;  Leon R. Perrie;  Peter Petoe;  Axel Dalberg Poulsen;  Ghillean T. Prance;  J. Peter Quakenbush;  Niels Raes;  Michele Rodda;  Zachary S. Rogers;  André;  Schuiteman;  Pedro Schwartsburd;  Robert W. Scotland;  Mark P. Simmons;  David A. Simpson;  Peter Stevens;  Michael Sundue;  Weston Testo;  Anna Trias-Blasi;  Ian Turner;  Timothy Utteridge;  Lesley Walsingham;  Bruce L. Webber;  Ran Wei;  George D. Weiblen;  Maximilian Weigend;  Peter Weston;  Willem de Wilde;  Peter Wilkie;  Christine M. Wilmot-Dear;  Hannah P. Wilson;  John R. I. Wood;  Li-Bing Zhang;  Peter C. van Welzen
收藏  |  浏览/下载:32/0  |  提交时间:2020/08/18
Atmospheric Evolution of Emissions from a Boreal Forest Fire: The Formation of Highly-Functionalized Oxygen-, Nitrogen-, and Sulfur-Containing Compounds 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Jenna C. Ditto, Megan He, Tori N. Hass-Mitchell, Samar G. Moussa, Katherine Hayden, Shao-Meng Li, John Liggio, Amy Leithead, Patrick Lee, Michael J. Wheeler, Jeremy J. B. Wenztell, and Drew R. Gentner
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/09
WHY POLLUTION IS FALLING IN SOME CITIES - BUT NOT OTHERS 期刊论文
NATURE, 2020, 580 (7803) : 313-313
作者:  Sulkowski, Parker L.;  Oeck, Sebastian;  Dow, Jonathan;  Economos, Nicholas G.;  Mirfakhraie, Lily;  Liu, Yanfeng;  Noronha, Katelyn;  Bao, Xun;  Li, Jing;  Shuch, Brian M.;  King, Megan C.;  Bindra, Ranjit S.;  Glazer, Peter M.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03
Chesapeake Bay acidification buffered by spatially decoupled carbonate mineral cycling 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 441-+
作者:  Su, Jianzhong;  Cai, Wei-Jun;  Brodeur, Jean;  Chen, Baoshan;  Hussain, Najid;  Yao, Yichen;  Ni, Chaoying;  Testa, Jeremy M.;  Li, Ming;  Xie, Xiaohui;  Ni, Wenfei;  Scaboo, K. Michael;  Xu, Yuan-yuan;  Cornwell, Jeffrey;  Gurbisz, Cassie;  Owens, Michael S.;  Waldbusser, George G.;  Dai, Minhan;  Kemp, W. Michael
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/09
Anthropogenic and volcanic point source SO2 emissions derived from TROPOMI on board Sentinel-5 Precursor: first results 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5591-5607
作者:  Fioletov, Vitali;  Mclinden, Chris A.;  Griffin, Debora;  Theys, Nicolas;  Loyola, Diego G.;  Hedelt, Pascal;  Krotkov, Nickolay A.;  Li, Can
收藏  |  浏览/下载:17/0  |  提交时间:2020/05/20
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Monumental architecture at Aguada Fenix and the rise of Maya civilization 期刊论文
NATURE, 2020
作者:  Bedding, Timothy R.;  Murphy, Simon J.;  Hey, Daniel R.;  Huber, Daniel;  Li, Tanda;  Smalley, Barry;  Stello, Dennis;  White, Timothy R.;  Ball, Warrick H.;  Chaplin, William J.;  Colman, Isabel L.;  Fuller, Jim;  Gaidos, Eric;  Harbeck, Daniel R.;  Hermes, J. J.;  Holdsworth, Daniel L.;  Li, Gang;  Li, Yaguang;  Mann, Andrew W.;  Reese, Daniel R.;  Sekaran, Sanjay;  Yu, Jie;  Antoci, Victoria;  Bergmann, Christoph;  Brown, Timothy M.;  Howard, Andrew W.;  Ireland, Michael J.;  Isaacson, Howard;  Jenkins, Jon M.;  Kjeldsen, Hans;  McCully, Curtis;  Rabus, Markus;  Rains, Adam D.;  Ricker, George R.;  Tinney, Christopher G.;  Vanderspek, Roland K.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

Archaeologists have traditionally thought that the development of Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclassic period (1000-350 bc  dates are calibrated throughout) along with the use of ceramics and the adoption of sedentism(1). Recent finds of early ceremonial complexes are beginning to challenge this model. Here we describe an airborne lidar survey and excavations of the previously unknown site of Aguada Fenix (Tabasco, Mexico) with an artificial plateau, which measures 1,400 m in length and 10 to 15 m in height and has 9 causeways radiating out from it. We dated this construction to between 1000 and 800 bc using a Bayesian analysis of radiocarbon dates. To our knowledge, this is the oldest monumental construction ever found in the Maya area and the largest in the entire pre-Hispanic history of the region. Although the site exhibits some similarities to the earlier Olmec centre of San Lorenzo, the community of Aguada Fenix probably did not have marked social inequality comparable to that of San Lorenzo. Aguada Fenix and other ceremonial complexes of the same period suggest the importance of communal work in the initial development of Maya civilization.


Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fenix, which dates to around 1000-800 bc and points to the role of communal construction in the development of Maya civilization.