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Increasing risk of another Cape Town “Day Zero” drought in the 21st century 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Salvatore Pascale;  Sarah B. Kapnick;  Thomas L. Delworth;  William F. Cooke
收藏  |  浏览/下载:9/0  |  提交时间:2020/11/20
A comprehensive quantification of global nitrous oxide sources and sinks 期刊论文
Nature, 2020
作者:  Hanqin Tian;  Rongting Xu;  Josep G. Canadell;  Rona L. Thompson;  Wilfried Winiwarter;  Parvadha Suntharalingam;  Eric A. Davidson;  Philippe Ciais;  Robert B. Jackson;  Greet Janssens-Maenhout;  Michael J. Prather;  Pierre Regnier;  Naiqing Pan;  Shufen Pan;  Glen P. Peters;  Hao Shi;  Francesco N. Tubiello;  ;  nke Zaehle;  Feng Zhou;  Almut Arneth;  Gianna Battaglia;  Sarah Berthet;  Laurent Bopp;  Alexander F. Bouwman;  Erik T. Buitenhuis;  Jinfeng Chang;  Martyn P. Chipperfield;  Shree R. S. Dangal;  Edward Dlugokencky;  James W. Elkins;  Bradley D. Eyre;  Bojie Fu;  Bradley Hall;  Akihiko Ito;  Fortunat Joos;  Paul B. Krummel;  Angela Landolfi;  Goulven G. Laruelle;  Ronny Lauerwald;  Wei Li;  Sebastian Lienert;  Taylor Maavara;  Michael MacLeod;  Dylan B. Millet;  Stefan Olin;  Prabir K. Patra;  Ronald G. Prinn;  Peter A. Raymond;  Daniel J. Ruiz;  Guido R. van der Werf;  Nicolas Vuichard;  Junjie Wang;  Ray F. Weiss;  Kelley C. Wells;  Chris Wilson;  Jia Yang;  Yuanzhi Yao
收藏  |  浏览/下载:24/0  |  提交时间:2020/10/12
Bending the curve of terrestrial biodiversity needs an integrated strategy 期刊论文
Nature, 2020
作者:  David Leclè;  re;  Michael Obersteiner;  Mike Barrett;  Stuart H. M. Butchart;  Abhishek Chaudhary;  Adriana De Palma;  Fabrice A. J. DeClerck;  Moreno Di Marco;  Jonathan C. Doelman;  Martina Dü;  rauer;  Robin Freeman;  Michael Harfoot;  Tomoko Hasegawa;  Stefanie Hellweg;  Jelle P. Hilbers;  Samantha L. L. Hill;  Florian Humpenö;  der;  Nancy Jennings;  Tamá;  s Krisztin;  Georgina M. Mace;  Haruka Ohashi;  Alexander Popp;  Andy Purvis;  Aafke M. Schipper;  Andrzej Tabeau;  Hugo Valin;  Hans van Meijl;  Willem-Jan van Zeist;  Piero Visconti;  Rob Alkemade;  Rosamunde Almond;  Gill Bunting;  Neil D. Burgess;  Sarah E. Cornell;  Fulvio Di Fulvio;  Simon Ferrier;  Steffen Fritz;  Shinichiro Fujimori;  Monique Grooten;  Thomas Harwood;  Petr Havlí;  k;  Mario Herrero;  Andrew J. Hoskins;  Martin Jung;  Tom Kram;  Hermann Lotze-Campen;  Tetsuya Matsui;  Carsten Meyer;  Deon Nel;  Tim Newbold;  Guido Schmidt-Traub;  Elke Stehfest;  Bernardo B. N. Strassburg;  Detlef P. van Vuuren;  Chris Ware;  James E. M. Watson;  Wenchao Wu;  Lucy Young
收藏  |  浏览/下载:77/0  |  提交时间:2020/09/14
Large stocks of peatland carbon and nitrogen are vulnerable to permafrost thaw 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Gustaf Hugelius;  Julie Loisel;  Sarah Chadburn;  Robert B. Jackson;  Miriam Jones;  Glen MacDonald;  Maija Marushchak;  David Olefeldt;  Maara Packalen;  Matthias B. Siewert;  Claire Treat;  Merritt Turetsky;  Carolina Voigt;  Zicheng Yu
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/18
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
PTR-TOF-MS eddy covariance measurements of isoprene and monoterpene fluxes from an eastern Amazonian rainforest 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7179-7191
作者:  Sarkar, Chinmoy;  Guenther, Alex B.;  Park, Jeong-Hoo;  Seco, Roger;  Alyes, Eliane;  Batalha, Sarah;  Santana, Raoni;  Kiml, Saewung;  Smith, James;  Tota, Julio;  Vega, Oscar
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Exploring dynamical phase transitions with cold atoms in an optical cavity 期刊论文
NATURE, 2020, 580 (7805) : 602-+
作者:  Halbach, Rebecca;  Miesen, Pascal;  Joosten, Joep;  Taskopru, Ezgi;  Rondeel, Inge;  Pennings, Bas;  Vogels, Chantal B. F.;  Merkling, Sarah H.;  Koenraadt, Constantianus J.;  Lambrechts, Louis;  van Rij, Ronald P.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Interactions between light and an ensemble of strontium atoms in an optical cavity can serve as a testbed for studying dynamical phase transitions, which are currently not well understood.


Interactions between atoms and light in optical cavities provide a means of investigating collective (many-body) quantum physics in controlled environments. Such ensembles of atoms in cavities have been proposed for studying collective quantum spin models, where the atomic internal levels mimic a spin degree of freedom and interact through long-range interactions tunable by changing the cavity parameters(1-4). Non-classical steady-state phases arising from the interplay between atom-light interactions and dissipation of light from the cavity have previously been investigated(5-11). These systems also offer the opportunity to study dynamical phases of matter that are precluded from existence at equilibrium but can be stabilized by driving a system out of equilibrium(12-16), as demonstrated by recent experiments(17-22). These phases can also display universal behaviours akin to standard equilibrium phase transitions(8,23,24). Here, we use an ensemble of about a million strontium-88 atoms in an optical cavity to simulate a collective Lipkin-Meshkov-Glick model(25,26), an iconic model in quantum magnetism, and report the observation of distinct dynamical phases of matter in this system. Our system allows us to probe the dependence of dynamical phase transitions on system size, initial state and other parameters. These observations can be linked to similar dynamical phases in related systems, including the Josephson effect in superfluid helium(27), or coupled atomic(28) and solid-state polariton(29) condensates. The system itself offers potential for generation of metrologically useful entangled states in optical transitions, which could permit quantum enhancement in state-of-the-art atomic clocks(30,31).


  
Signatures of self-organized criticality in an ultracold atomic gas 期刊论文
NATURE, 2020, 577 (7791) : 481-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  De Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Self-organized criticality is an elegant explanation of how complex structures emerge and persist throughout nature(1), and why such structures often exhibit similar scale-invariant properties(2-9). Although self-organized criticality is sometimes captured by simple models that feature a critical point as an attractor for the dynamics(10-15), the connection to real-world systems is exceptionally hard to test quantitatively(16-21). Here we observe three key signatures of self-organized criticality in the dynamics of a driven-dissipative gas of ultracold potassium atoms: self-organization to a stationary state that is largely independent of the initial conditions  scale-invariance of the final density characterized by a unique scaling function  and large fluctuations of the number of excited atoms (avalanches) obeying a characteristic power-law distribution. This work establishes a well-controlled platform for investigating self-organization phenomena and non-equilibrium criticality, with experimental access to the underlying microscopic details of the system.


A driven-dissipative gas of ultracold potassium atoms is used to demonstrate three key signatures of self-organized criticality, and provides a system in which the phenomenon can be experimentally tested.