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Unexpected river water quality deterioration due to stormwater management in an urbanizing watershed 期刊论文
Water Resources Research, 2021
作者:  Xiaoyue Zhang;  Lei Chen;  Guowangchen Liu;  Yu Yu;  Yukun Ma;  Zhenyao Shen
收藏  |  浏览/下载：13/0  |  提交时间：2021/11/15
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus 期刊论文
Science, 2021
作者:  Yongkun Chen;  Laura Graf;  Tao Chen;  Qijun Liao;  Tian Bai;  Philipp P. Petric;  Wenfei Zhu;  Lei Yang;  Jie Dong;  Jian Lu;  Ying Chen;  Juan Shen;  Otto Haller;  Peter Staeheli;  Georg Kochs;  Dayan Wang;  Martin Schwemmle;  Yuelong Shu
收藏  |  浏览/下载：16/0  |  提交时间：2021/08/25
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载：17/0  |  提交时间：2021/04/06
Global COVID-19 pandemic demands joint interventions for the suppression of future waves 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Ruiyun Li;  Bin Chen;  Tao Zhang;  Zhehao Ren;  Yimeng Song;  Yixiong Xiao;  Lin Hou;  Jun Cai;  Bo Xu;  Miao Li;  Karen Kie Yan Chan;  Ying Tu;  Mu Yang;  Jing Yang;  Zhaoyang Liu;  Chong Shen;  Che Wang;  Lei Xu;  Qiyong Liu;  Shuming Bao;  Jianqin Zhang;  Yuhai Bi;  Yuqi Bai;  Ke Deng;  Wusheng Zhang;  Wenyu Huang;  Jason D. Whittington;  Nils Chr. Stenseth;  Dabo Guan;  Peng Gong;  Bing Xu
收藏  |  浏览/下载：14/0  |  提交时间：2020/10/12
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
Science, 2020
作者:  Yan Wu;  Feiran Wang;  Chenguang Shen;  Weiyu Peng;  Delin Li;  Cheng Zhao;  Zhaohui Li;  Shihua Li;  Yuhai Bi;  Yang Yang;  Yuhuan Gong;  Haixia Xiao;  Zheng Fan;  Shuguang Tan;  Guizhen Wu;  Wenjie Tan;  Xuancheng Lu;  Changfa Fan;  Qihui Wang;  Yingxia Liu;  Chen Zhang;  Jianxun Qi;  George Fu Gao;  Feng Gao;  Lei Liu
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/16
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Nitrifier adaptation to low energy flux controls inventory of reduced nitrogen in the dark ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4823-4830
作者:  Zhang, Yao;  Qin, Wei;  Hou, Lei;  Zakem, Emily J.;  Wan, Xianhui;  Zhao, Zihao;  Liu, Li;  Hunt, Kristopher A.;  Jiao, Nianzhi;  Kao, Shuh-Ji;  Tang, Kai;  Xie, Xiabing;  Shen, Jiaming;  Li, Yufang;  Chen, Mingming;  Dai, Xiaofeng;  Liu, Chang;  Deng, Wenchao;  Dai, Minhan;  Ingalls, Anitra E.;  Stahl, David A.;  Herndl, Gerhard J.
收藏  |  浏览/下载：14/0  |  提交时间：2020/05/13
nitrification  dark ocean  nitrogen flux  carbon fixation  homeostasis  
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Huang, Fengjie;  Zheng, Xiaojiao;  Ma, Xiaohui;  Jiang, Runqiu;  Zhou, Wangyi;  Zhou, Shuiping;  Zhang, Yunjing;  Lei, Sha;  Wang, Shouli;  Kuang, Junliang;  Han, Xiaolong;  Wei, Meilin;  You, Yijun;  Li, Mengci;  Li, Yitao;  Liang, Dandan;  Liu, Jiajian;  Chen, Tianlu;  Yan, Chao;  Wei, Runmin;  Rajani, Cynthia;  Shen, Chengxing;  Xie, Guoxiang;  Bian, Zhaoxiang;  Li, Houkai;  Zhao, Aihua;  Jia, Wei
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jiang, Xi;  Hu, Chao;  Ferchen, Kyle;  Nie, Ji;  Cui, Xiaolong;  Chen, Chih-Hong;  Cheng, Liting;  Zuo, Zhixiang;  Seibel, William;  He, Chunjiang;  Tang, Yixuan;  Skibbe, Jennifer R.;  Wunderlich, Mark;  Reinhold, William C.;  Dong, Lei;  Shen, Chao;  Arnovitz, Stephen;  Ulrich, Bryan;  Lu, Jiuwei;  Weng, Hengyou;  Su, Rui;  Huang, Huilin;  Wang, Yungui;  Li, Chenying;  Qin, Xi;  Mulloy, James;  Zheng, Yi;  Diao, Jiajie;  Jin, Jie;  Li, Chong;  Liu, Paul P.;  He, Chuan;  Chen, Yuan;  Chen, Jianjun
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Selective self-assembly of 2,3-diaminophenazine molecules on MoSe2 mirror twin boundaries 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  He, Xiaoyue;  Zhang, Lei;  Chua, Rebekah;  Wong, Ping Kwan Johnny;  Arramel, Arramel;  Feng, Yuan Ping;  Wang, Shi Jie;  Chi, Dongzhi;  Yang, Ming;  Huang, Yu Li;  Wee, Andrew Thye Shen
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27