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DOI | 10.1038/ncomms15519 |
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism | |
Huang, Fengjie1,2,3; Zheng, Xiaojiao1,2; Ma, Xiaohui4; Jiang, Runqiu5; Zhou, Wangyi4; Zhou, Shuiping4; Zhang, Yunjing1,2; Lei, Sha1,2; Wang, Shouli1,2; Kuang, Junliang1,2; Han, Xiaolong1,2; Wei, Meilin1,2; You, Yijun1,2; Li, Mengci1,2; Li, Yitao1,2; Liang, Dandan1,2; Liu, Jiajian1,2; Chen, Tianlu1,2; Yan, Chao3; Wei, Runmin5; Rajani, Cynthia5; Shen, Chengxing6; Xie, Guoxiang5; Bian, Zhaoxiang7; Li, Houkai8; Zhao, Aihua1,2; Jia, Wei1,2,5,7 | |
2019-10-31 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. Theabrownin increases the levels of ileal conjugated bile acids (BAs) which, in turn, inhibit the intestinal FXR-FGF15 signaling pathway, resulting in increased hepatic production and fecal excretion of BAs, reduced hepatic cholesterol, and decreased lipogenesis. The inhibition of intestinal FXR-FGF15 signaling is accompanied by increased gene expression of enzymes in the alternative BA synthetic pathway, production of hepatic chenodeoxycholic acid, activation of hepatic FXR, and hepatic lipolysis. Our results shed light into the mechanisms behind the cholesterol- and lipid-lowering effects of Pu-erh tea, and suggest that decreased intestinal BSH microbes and/or decreased FXR-FGF15 signaling may be potential anti-hypercholesterolemia and anti-hyperlipidemia |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493438700019 |
WOS关键词 | FARNESOID-X-RECEPTOR ; SALT HYDROLASE ACTIVITY ; GROWTH-FACTOR 15 ; GREEN TEA ; BODY-FAT ; BLACK ; INTESTINE ; HEALTHY ; OOLONG ; RATS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203320 |
专题 | 资源环境科学 |
作者单位 | 1.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China; 4.Tasly Pharmaceut Co Ltd, Dept Pharmacol & Toxicol, Tianjin, Peoples R China; 5.Univ Hawaii, Canc Ctr, Honolulu, HI 96822 USA; 6.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai, Peoples R China; 7.Hong Kong Baptist Univ, Sch Chinese Med, Chinese Med Clin Study Ctr, Hong Kong, Peoples R China; 8.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Funct Metab & Gut Microbiome Lab, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, Fengjie,Zheng, Xiaojiao,Ma, Xiaohui,et al. Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Huang, Fengjie.,Zheng, Xiaojiao.,Ma, Xiaohui.,Jiang, Runqiu.,Zhou, Wangyi.,...&Jia, Wei.(2019).Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism.NATURE COMMUNICATIONS,10. |
MLA | Huang, Fengjie,et al."Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism".NATURE COMMUNICATIONS 10(2019). |
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