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Senolytics reduce coronavirus-related mortality in old mice 期刊论文
Science, 2021
作者:  Christina D. Camell;  Matthew J. Yousefzadeh;  Yi Zhu;  Larissa G. P. Langhi Prata;  Matthew A. Huggins;  Mark Pierson;  Lei Zhang;  Ryan D. O’Kelly;  Tamar Pirtskhalava;  Pengcheng Xun;  Keisuke Ejima;  Ailing Xue;  Utkarsh Tripathi;  Jair Machado Espindola-Netto;  Nino Giorgadze;  Elizabeth J. Atkinson;  Christina L. Inman;  Kurt O. Johnson;  Stephanie H. Cholensky;  Timothy W. Carlson;  Nathan K. LeBrasseur;  Sundeep Khosla;  M. Gerard O’Sullivan;  David B. Allison;  Stephen C. Jameson;  Alexander Meves;  Ming Li;  Y. S. Prakash;  Sergio E. Chiarella;  Sara E. Hamilton;  Tamara Tchkonia;  Laura J. Niedernhofer;  James L. Kirkland;  Paul D. Robbins
收藏  |  浏览/下载:15/0  |  提交时间:2021/07/27
Subpolar North Atlantic western boundary density anomalies and the Meridional Overturning Circulation 期刊论文
Nature Communications, 2021
作者:  F. Li;  M. S. Lozier;  S. Bacon;  A. S. Bower;  S. A. Cunningham;  M. F. de Jong;  B. deYoung;  N. Fraser;  N. Fried;  G. Han;  N. P. Holliday;  J. Holte;  L. Houpert;  M. E. Inall;  W. E. Johns;  S. Jones;  C. Johnson;  J. Karstensen;  I. A. Le Bras;  P. Lherminier;  X. Lin;  H. Mercier;  M. Oltmanns;  A. Pacini;  T. Petit;  R. S. Pickart;  D. Rayner;  F. Straneo;  V. Thierry;  M. Visbeck;  I. Yashayaev;  C. Zhou
收藏  |  浏览/下载:12/0  |  提交时间:2021/06/07
Contrasting drivers of diversity in hosts and parasites across the tropical Andes 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  Sabrina M. McNew;  Lisa N. Barrow;  Jessie L. Williamson;  Spencer C. Galen;  Heather R. Skeen;  Shane G. DuBay;  Ariel M. Gaffney;  Andrew B. Johnson;  Emil Bautista;  Paloma Ordoñez;  C. Jonathan Schmitt;  Ashley Smiley;  Thomas Valqui;  John M. Bates;  Shannon J. Hackett;  Christopher C. Witt
收藏  |  浏览/下载:9/0  |  提交时间:2021/03/29
Combating ecosystem collapse from the tropics to the Antarctic 期刊论文
Global Change Biology, 2021
作者:  Dana M. Bergstrom;  Barbara C. Wienecke;  John van den Hoff;  Lesley Hughes;  David B. Lindenmayer;  Tracy D. Ainsworth;  Christopher M. Baker;  Lucie Bland;  David M. J. S. Bowman;  Shaun T. Brooks;  Josep G. Canadell;  Andrew J. Constable;  Katherine A. Dafforn;  Michael H. Depledge;  Catherine R. Dickson;  Norman C. Duke;  Kate J. Helmstedt;  André;  s Holz;  Craig R. Johnson;  Melodie A. McGeoch;  Jessica Melbourne‐;  Thomas;  Rachel Morgain;  Emily Nicholson;  Suzanne M. Prober;  Ben Raymond;  Euan G. Ritchie;  Sharon A. Robinson;  Katinka X. Ruthrof;  Samantha A. Setterfield;  Carla M. Sgrò;  Jonathan S. Stark;  Toby Travers;  Rowan Trebilco;  Delphi F. L. Ward;  Glenda M. Wardle;  Kristen J. Williams;  Phillip J. Zylstra;  Justine D. Shaw
收藏  |  浏览/下载:12/0  |  提交时间:2021/03/02
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:25/0  |  提交时间:2020/12/07
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic 期刊论文
Science, 2020
作者:  Emily N. Chin;  Chenguang Yu;  Vincent F. Vartabedian;  Ying Jia;  Manoj Kumar;  Ana M. Gamo;  William Vernier;  Sabrina H. Ali;  Mildred Kissai;  Daniel C. Lazar;  Nhan Nguyen;  Laura E. Pereira;  Brent Benish;  Ashley K. Woods;  Sean B. Joseph;  Alan Chu;  Kristen A. Johnson;  Philipp N. Sander;  Francisco Martínez-Peña;  Eric N. Hampton;  Travis S. Young;  Dennis W. Wolan;  Arnab K. Chatterjee;  Peter G. Schultz;  H. Michael Petrassi;  John R. Teijaro;  Luke L. Lairson
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
Climate change considerations are fundamental to management of deep‐sea resource extraction 期刊论文
Global Change Biology, 2020
作者:  Lisa A. Levin;  Chih‐;  Lin Wei;  Daniel C. Dunn;  Diva J. Amon;  Oliver S. Ashford;  William W. L. Cheung;  Ana Colaç;  o;  Carlos Dominguez‐;  Carrió;  Elva G. Escobar;  Harriet R. Harden‐;  Davies;  Jeffrey C. Drazen;  Khaira Ismail;  Daniel O. B. Jones;  David E. Johnson;  Jennifer T. Le;  Franck Lejzerowicz;  Satoshi Mitarai;  Telmo Morato;  Sandor Mulsow;  Paul V. R. Snelgrove;  Andrew K. Sweetman;  Moriaki Yasuhara
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/09
Pervasive shifts in forest dynamics in a changing world 期刊论文
Science, 2020
作者:  Nate G. McDowell;  Craig D. Allen;  Kristina Anderson-Teixeira;  Brian H. Aukema;  Ben Bond-Lamberty;  Louise Chini;  James S. Clark;  Michael Dietze;  Charlotte Grossiord;  Adam Hanbury-Brown;  George C. Hurtt;  Robert B. Jackson;  Daniel J. Johnson;  Lara Kueppers;  Jeremy W. Lichstein;  Kiona Ogle;  Benjamin Poulter;  Thomas A. M. Pugh;  Rupert Seidl;  Monica G. Turner;  Maria Uriarte;  Anthony P. Walker;  Chonggang Xu
收藏  |  浏览/下载:17/0  |  提交时间:2020/06/01
ECOSTRESS: NASA's Next Generation Mission to Measure Evapotranspiration From the International Space Station 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (4)
作者:  Fisher, Joshua B.;  Lee, Brian;  Purdy, Adam J.;  Halverson, Gregory H.;  Dohlen, Matthew B.;  Cawse-Nicholson, Kerry;  Wang, Audrey;  Anderson, Ray G.;  Aragon, Bruno;  Arain, M. Altaf;  Baldocchi, Dennis D.;  Baker, John M.;  Barral, Helene;  Bernacchi, Carl J.;  Bernhofer, Christian;  Biraud, Sebastien C.;  Bohrer, Gil;  Brunsell, Nathaniel;  Cappelaere, Bernard;  Castro-Contreras, Saulo;  Chun, Junghwa;  Conrad, Bryan J.;  Cremonese, Edoardo;  Demarty, Jerome;  Desai, Ankur R.;  De Ligne, Anne;  Foltynova, Lenka;  Goulden, Michael L.;  Griffis, Timothy J.;  Gruenwald, Thomas;  Johnson, Mark S.;  Kang, Minseok;  Kelbe, Dave;  Kowalska, Natalia;  Lim, Jong-Hwan;  Mainassara, Ibrahim;  McCabe, Matthew F.;  Missik, Justine E. C.;  Mohanty, Binayak P.;  Moore, Caitlin E.;  Morillas, Laura;  Morrison, Ross;  Munger, J. William;  Posse, Gabriela;  Richardson, Andrew D.;  Russell, Eric S.;  Ryu, Youngryel;  Sanchez-Azofeifa, Arturo;  Schmidt, Marius;  Schwartz, Efrat;  Sharp, Iain;  Sigut, Ladislav;  Tang, Yao;  Hulley, Glynn;  Anderson, Martha;  Hain, Christopher;  French, Andrew;  Wood, Eric;  Hook, Simon
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/02
ECOSTRESS  eddy covariance  evapotranspiration  latent heat flux  satellite  validation  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.