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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity 期刊论文
Science, 2021
作者:  Parsa Akbari;  Ankit Gilani;  Olukayode Sosina;  Jack A. Kosmicki;  Lori Khrimian;  Yi-Ya Fang;  Trikaldarshi Persaud;  Victor Garcia;  Dylan Sun;  Alexander Li;  Joelle Mbatchou;  Adam E. Locke;  Christian Benner;  Niek Verweij;  Nan Lin;  Sakib Hossain;  Kevin Agostinucci;  Jonathan V. Pascale;  Ercument Dirice;  Michael Dunn;  Regeneron Genetics Center‡;  DiscovEHR Collaboration‡;  William E. Kraus;  Svati H. Shah;  Yii-Der I. Chen;  Jerome I. Rotter;  Daniel J. Rader;  Olle Melander;  Christopher D. Still;  Tooraj Mirshahi;  David J. Carey;  Jaime Berumen-Campos;  Pablo Kuri-Morales;  Jesus Alegre-Díaz;  Jason M. Torres;  Jonathan R. Emberson;  Rory Collins;  Suganthi Balasubramanian;  Alicia Hawes;  Marcus Jones;  Brian Zambrowicz;  Andrew J. Murphy;  Charles Paulding;  Giovanni Coppola;  John D. Overton;  Jeffrey G. Reid;  Alan R. Shuldiner;  Michael Cantor;  Hyun M. Kang;  Goncalo R. Abecasis;  Katia Karalis;  Aris N. Economides;  Jonathan Marchini;  George D. Yancopoulos;  Mark W. Sleeman;  Judith Altarejos;  Giusy Della Gatta;  Roberto Tapia-Conyer;  Michal L. Schwartzman;  Aris Baras;  Manuel A. R. Ferreira;  Luca A. Lotta
收藏  |  浏览/下载:26/0  |  提交时间:2021/07/27
Targeting a neoantigen derived from a common TP53 mutation 期刊论文
Science, 2021
作者:  Emily Han-Chung Hsiue;  Katharine M. Wright;  Jacqueline Douglass;  Michael S. Hwang;  Brian J. Mog;  Alexander H. Pearlman;  Suman Paul;  Sarah R. DiNapoli;  Maximilian F. Konig;  Qing Wang;  Annika Schaefer;  Michelle S. Miller;  Andrew D. Skora;  P. Aitana Azurmendi;  Michael B. Murphy;  Qiang Liu;  Evangeline Watson;  Yana Li;  Drew M. Pardoll;  Chetan Bettegowda;  Nickolas Papadopoulos;  Kenneth W. Kinzler;  Bert Vogelstein;  Sandra B. Gabelli;  Shibin Zhou
收藏  |  浏览/下载:9/0  |  提交时间:2021/03/12
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver 期刊论文
Science, 2021
作者:  Fotios Sampaziotis;  Daniele Muraro;  Olivia C. Tysoe;  Stephen Sawiak;  Timothy E. Beach;  Edmund M. Godfrey;  Sara S. Upponi;  Teresa Brevini;  Brandon T. Wesley;  Jose Garcia-Bernardo;  Krishnaa Mahbubani;  Giovanni Canu;  Richard Gieseck;  Natalie L. Berntsen;  Victoria L. Mulcahy;  Keziah Crick;  Corrina Fear;  Sharayne Robinson;  Lisa Swift;  Laure Gambardella;  Johannes Bargehr;  Daniel Ortmann;  Stephanie E. Brown;  Anna Osnato;  Michael P. Murphy;  Gareth Corbett;  William T. H. Gelson;  George F. Mells;  Peter Humphreys;  Susan E. Davies;  Irum Amin;  Paul Gibbs;  Sanjay Sinha;  Sarah A. Teichmann;  Andrew J. Butler;  Teik Choon See;  Espen Melum;  Christopher J. E. Watson;  Kourosh Saeb-Parsy;  Ludovic Vallier
收藏  |  浏览/下载:15/0  |  提交时间:2021/02/22
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth 期刊论文
Science, 2021
作者:  Ryan S. Roark;  Hui Li;  Wilton B. Williams;  Hema Chug;  Rosemarie D. Mason;  Jason Gorman;  Shuyi Wang;  Fang-Hua Lee;  Juliette Rando;  Mattia Bonsignori;  Kwan-Ki Hwang;  Kevin O. Saunders;  Kevin Wiehe;  M. Anthony Moody;  Peter T. Hraber;  Kshitij Wagh;  Elena E. Giorgi;  Ronnie M. Russell;  Frederic Bibollet-Ruche;  Weimin Liu;  Jesse Connell;  Andrew G. Smith;  Julia DeVoto;  Alexander I. Murphy;  Jessica Smith;  Wenge Ding;  Chengyan Zhao;  Neha Chohan;  Maho Okumura;  Christina Rosario;  Yu Ding;  Emily Lindemuth;  Anya M. Bauer;  Katharine J. Bar;  David Ambrozak;  Cara W. Chao;  Gwo-Yu Chuang;  Hui Geng;  Bob C. Lin;  Mark K. Louder;  Richard Nguyen;  Baoshan Zhang;  Mark G. Lewis;  Donald D. Raymond;  Nicole A. Doria-Rose;  Chaim A. Schramm;  Daniel C. Douek;  Mario Roederer;  Thomas B. Kepler;  Garnett Kelsoe;  John R. Mascola;  Peter D. Kwong;  Bette T. Korber;  Stephen C. Harrison;  Barton F. Haynes;  Beatrice H. Hahn;  George M. Shaw
收藏  |  浏览/下载:20/0  |  提交时间:2021/01/15
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters 期刊论文
Science, 2020
作者:  Alina Baum;  Dharani Ajithdoss;  Richard Copin;  Anbo Zhou;  Kathryn Lanza;  Nicole Negron;  Min Ni;  Yi Wei;  Kusha Mohammadi;  Bret Musser;  Gurinder S. Atwal;  Adelekan Oyejide;  Yenny Goez-Gazi;  John Dutton;  Elizabeth Clemmons;  Hilary M. Staples;  Carmen Bartley;  Benjamin Klaffke;  Kendra Alfson;  Michal Gazi;  Olga Gonzalez;  Edward Dick;  Ricardo Carrion;  Laurent Pessaint;  Maciel Porto;  Anthony Cook;  Renita Brown;  Vaneesha Ali;  Jack Greenhouse;  Tammy Taylor;  Hanne Andersen;  Mark G. Lewis;  Neil Stahl;  Andrew J. Murphy;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:13/0  |  提交时间:2020/11/30
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail 期刊论文
Science, 2020
作者:  Johanna Hansen;  Alina Baum;  Kristen E. Pascal;  Vincenzo Russo;  Stephanie Giordano;  Elzbieta Wloga;  Benjamin O. Fulton;  Ying Yan;  Katrina Koon;  Krunal Patel;  Kyung Min Chung;  Aynur Hermann;  Erica Ullman;  Jonathan Cruz;  Ashique Rafique;  Tammy Huang;  Jeanette Fairhurst;  Christen Libertiny;  Marine Malbec;  Wen-yi Lee;  Richard Welsh;  Glen Farr;  Seth Pennington;  Dipali Deshpande;  Jemmie Cheng;  Anke Watty;  Pascal Bouffard;  Robert Babb;  Natasha Levenkova;  Calvin Chen;  Bojie Zhang;  Annabel Romero Hernandez;  Kei Saotome;  Yi Zhou;  Matthew Franklin;  Sumathi Sivapalasingam;  David Chien Lye;  Stuart Weston;  James Logue;  Robert Haupt;  Matthew Frieman;  Gang Chen;  William Olson;  Andrew J. Murphy;  Neil Stahl;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/25
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies 期刊论文
Science, 2020
作者:  Alina Baum;  Benjamin O. Fulton;  Elzbieta Wloga;  Richard Copin;  Kristen E. Pascal;  Vincenzo Russo;  Stephanie Giordano;  Kathryn Lanza;  Nicole Negron;  Min Ni;  Yi Wei;  Gurinder S. Atwal;  Andrew J. Murphy;  Neil Stahl;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:7/0  |  提交时间:2020/08/25
Exploring movement patterns and changing distributions of baleen whales in the western North Atlantic using a decade of passive acoustic data 期刊论文
Global Change Biology, 2020
作者:  Genevieve E. Davis;  Mark F. Baumgartner;  Peter J. Corkeron;  Joel Bell;  Catherine Berchok;  Julianne M. Bonnell;  Jacqueline Bort Thornton;  Solange Brault;  Gary A. Buchanan;  Danielle M. Cholewiak;  Christopher W. Clark;  Julien Delarue;  Leila T. Hatch;  Holger Klinck;  Scott D. Kraus;  Bruce Martin;  David K. Mellinger;  Hilary Moors‐;  Murphy;  Sharon Nieukirk;  Douglas P. Nowacek;  Susan E. Parks;  Dawn Parry;  Nicole Pegg;  Andrew J. Read;  Aaron N. Rice;  Denise Risch;  Alyssa Scott;  Melissa S. Soldevilla;  Kathleen M. Stafford;  Joy E. Stanistreet;  Erin Summers;  Sean Todd;  Sofie M. Van Parijs
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/14
Monumental architecture at Aguada Fenix and the rise of Maya civilization 期刊论文
NATURE, 2020
作者:  Bedding, Timothy R.;  Murphy, Simon J.;  Hey, Daniel R.;  Huber, Daniel;  Li, Tanda;  Smalley, Barry;  Stello, Dennis;  White, Timothy R.;  Ball, Warrick H.;  Chaplin, William J.;  Colman, Isabel L.;  Fuller, Jim;  Gaidos, Eric;  Harbeck, Daniel R.;  Hermes, J. J.;  Holdsworth, Daniel L.;  Li, Gang;  Li, Yaguang;  Mann, Andrew W.;  Reese, Daniel R.;  Sekaran, Sanjay;  Yu, Jie;  Antoci, Victoria;  Bergmann, Christoph;  Brown, Timothy M.;  Howard, Andrew W.;  Ireland, Michael J.;  Isaacson, Howard;  Jenkins, Jon M.;  Kjeldsen, Hans;  McCully, Curtis;  Rabus, Markus;  Rains, Adam D.;  Ricker, George R.;  Tinney, Christopher G.;  Vanderspek, Roland K.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

Archaeologists have traditionally thought that the development of Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclassic period (1000-350 bc  dates are calibrated throughout) along with the use of ceramics and the adoption of sedentism(1). Recent finds of early ceremonial complexes are beginning to challenge this model. Here we describe an airborne lidar survey and excavations of the previously unknown site of Aguada Fenix (Tabasco, Mexico) with an artificial plateau, which measures 1,400 m in length and 10 to 15 m in height and has 9 causeways radiating out from it. We dated this construction to between 1000 and 800 bc using a Bayesian analysis of radiocarbon dates. To our knowledge, this is the oldest monumental construction ever found in the Maya area and the largest in the entire pre-Hispanic history of the region. Although the site exhibits some similarities to the earlier Olmec centre of San Lorenzo, the community of Aguada Fenix probably did not have marked social inequality comparable to that of San Lorenzo. Aguada Fenix and other ceremonial complexes of the same period suggest the importance of communal work in the initial development of Maya civilization.


Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fenix, which dates to around 1000-800 bc and points to the role of communal construction in the development of Maya civilization.


  
Structure, Variability, and Mean-Flow Interactions of the January 2015 Quasi-2-Day Wave at Middle and High Southern Latitudes 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (12) : 5981-6008
作者:  Fritts, David C.;  Iimura, Hiroyuki;  Janches, Diego;  Lieberman, Ruth S.;  Riggin, Dennis M.;  Mitchell, Nicholas J.;  Vincent, Robert A.;  Reid, Iain M.;  Murphy, Damian J.;  Tsutsumi, Masaki;  Kavanagh, Andrew J.;  Batista, Paulo P.;  Hocking, Wayne K.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
quasi-2-day wave  quasi-2-day wave transience  planetary-wave  mean-flow interactions  planetary-wave Eliassen-Palm fluxes