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Thermal adaptation occurs in the respiration and growth of widely distributed bacteria 期刊论文
Global Change Biology, 2022
作者:  Weitao Tian;  Huimin Sun;  Yan Zhang;  Jianjun Xu;  Jia Yao;  Jinquan Li;  Bo Li;  Ming Nie
收藏  |  浏览/下载:15/0  |  提交时间:2022/02/23
Timing and magnitude of climatic extremes differentially elevate mortality but enhance recovery in a fish population 期刊论文
Global Change Biology, 2021
作者:  Ming-Chih Chiu;  Shih-Hsun Chang;  Yu-Ting Yen;  Lin-Yan Liao;  Hsing-Juh Lin
收藏  |  浏览/下载:7/0  |  提交时间:2021/10/07
Echolocation in soft-furred tree mice 期刊论文
Science, 2021
作者:  Kai He;  Qi Liu;  Dong-Ming Xu;  Fei-Yan Qi;  Jing Bai;  Shui-Wang He;  Peng Chen;  Xin Zhou;  Wan-Zhi Cai;  Zhong-Zheng Chen;  Zhen Liu;  Xue-Long Jiang;  Peng Shi
收藏  |  浏览/下载:11/0  |  提交时间:2021/06/24
Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance 期刊论文
Global Change Biology, 2021
作者:  Ming‐;  ling Liao;  Gao‐;  yang Li;  Jie Wang;  David J. Marshall;  Tin Yan Hui;  Shu‐;  yang Ma;  Yi‐;  min Zhang;  Brian Helmuth;  Yun‐;  wei Dong
收藏  |  浏览/下载:12/0  |  提交时间:2021/03/29
Quantum computational advantage using photons 期刊论文
Science, 2020
作者:  Han-Sen Zhong;  Hui Wang;  Yu-Hao Deng;  Ming-Cheng Chen;  Li-Chao Peng;  Yi-Han Luo;  Jian Qin;  Dian Wu;  Xing Ding;  Yi Hu;  Peng Hu;  Xiao-Yan Yang;  Wei-Jun Zhang;  Hao Li;  Yuxuan Li;  Xiao Jiang;  Lin Gan;  Guangwen Yang;  Lixing You;  Zhen Wang;  Li Li;  Nai-Le Liu;  Chao-Yang Lu;  Jian-Wei Pan
收藏  |  浏览/下载:39/0  |  提交时间:2020/12/22
Reconsidering the fate of fertilizer N: A response to Quan et al. 期刊论文
Global Change Biology, 2020
作者:  Richard T. Conant;  Jocelyn M. Lavallee;  Ming Yan;  Genxing Pan
收藏  |  浏览/下载:7/0  |  提交时间:2020/12/07
Light grazing facilitates carbon accumulation in subsoil in Chinese grasslands: A meta‐analysis 期刊论文
Global Change Biology, 2020
作者:  Zhi‐;  Yun Jiang;  Zhong‐;  Min Hu;  Derrick Y. F. Lai;  Dao‐;  Rui Han;  Mei Wang;  Min Liu;  Meng Zhang;  Ming‐;  Yan Guo
收藏  |  浏览/下载:9/0  |  提交时间:2020/10/12
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/20
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).