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Lysyl oxidase is essential for hypoxia-induced metastasis (Retraction of Vol 440, Pg 1222, 2006) 期刊论文
NATURE, 2020, 579 (7799) : 456-456
作者:  Asaad, Serwan;  Mourik, Vincent;  Joecker, Benjamin;  Johnson, Mark A. I.;  Baczewski, Andrew D.;  Firgau, Hannes R.;  Madzik, Mateusz T.;  Schmitt, Vivien;  Pla, Jarryd J.;  Hudson, Fay E.;  Itoh, Kohei M.;  McCallum, Jeffrey C.;  Dzurak, Andrew S.;  Laucht, Arne;  Morello, Andrea
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

A Retraction to this paper has been published and can be accessed via a link at the top of the paper.


  
GDF15 mediates the effects of metformin on body weight and energy balance (vol 74, pg 856, 2019) 期刊论文
NATURE, 2020
作者:  Schulz, Frederik;  Roux, Simon;  Paez-Espino, David;  Jungbluth, Sean;  Walsh, David A.;  Denef, Vincent J.;  McMahon, Katherine D.;  Konstantinidis, Konstantinos T.;  Eloe-Fadrosh, Emiley A.;  Kyrpides, Nikos C.;  Woyke, Tanja
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/03
Classification with a disordered dopantatom network in silicon 期刊论文
NATURE, 2020, 577 (7790) : 341-+
作者:  Vagnozzi, Ronald J.;  Maillet, Marjorie;  Sargent, Michelle A.;  Khalil, Hadi;  Johansen, Anne Katrine Z.;  Schwanekamp, Jennifer A.;  York, Allen J.;  Huang, Vincent;  Nahrendorf, Matthias;  Sadayappan, Sakthivel;  Molkentin, Jeffery D.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Classification is an important task at which both biological and artificial neural networks excel(1,2). In machine learning, nonlinear projection into a high-dimensional feature space can make data linearly separable(3,4), simplifying the classification of complex features. Such nonlinear projections are computationally expensive in conventional computers. A promising approach is to exploit physical materials systems that perform this nonlinear projection intrinsically, because of their high computational density(5), inherent parallelism and energy efficiency(6,7). However, existing approaches either rely on the systems'  time dynamics, which requires sequential data processing and therefore hinders parallel computation(5,6,8), or employ large materials systems that are difficult to scale up(7). Here we use a parallel, nanoscale approach inspired by filters in the brain(1) and artificial neural networks(2) to perform nonlinear classification and feature extraction. We exploit the nonlinearity of hopping conduction(9-11) through an electrically tunable network of boron dopant atoms in silicon, reconfiguring the network through artificial evolution to realize different computational functions. We first solve the canonical two-input binary classification problem, realizing all Boolean logic gates(12) up to room temperature, demonstrating nonlinear classification with the nanomaterial system. We then evolve our dopant network to realize feature filters(2) that can perform four-input binary classification on the Modified National Institute of Standards and Technology handwritten digit database. Implementation of our material-based filters substantially improves the classification accuracy over that of a linear classifier directly applied to the original data(13). Our results establish a paradigm of silicon-based electronics for smallfootprint and energy-efficient computation(14).


  
Images from the surface of asteroid Ryugu show rocks similar to carbonaceous chondrite meteorites 期刊论文
SCIENCE, 2019, 365 (6455) : 817-+
作者:  Jaumann, R.;  Schmitz, N.;  Ho, T. -M.;  Schroder, S. E.;  Otto, K. A.;  Stephan, K.;  Elgner, S.;  Krohn, K.;  Preusker, F.;  Scholten, F.;  Biele, J.;  Ulamec, S.;  Krause, C.;  Sugita, S.;  Matz, K. -D.;  Roatsch, T.;  Parekh, R.;  Mottola, S.;  Grott, M.;  Michel, P.;  Trauthan, F.;  Koncz, A.;  Michaelis, H.;  Lange, C.;  Grundmann, J. T.;  Maibaum, M.;  Sasaki, K.;  Wolff, F.;  Reill, J.;  Moussi-Soffys, A.;  Lorda, L.;  Neumann, W.;  Vincent, J. -B.;  Wagner, R.;  Bibring, J. -P.;  Kameda, S.;  Yano, H.;  Watanabe, S.;  Yoshikawa, M.;  Tsuda, Y.;  Okada, T.;  Yoshimitsu, T.;  Mimasu, Y.;  Saiki, T.;  Yabuta, H.;  Rauer, H.;  Honda, R.;  Morota, T.;  Yokota, Y.;  Kouyama, T.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis 期刊论文
SCIENCE, 2019, 365 (6451) : 386-+
作者:  Chaurasia, Bhagirath;  Tippetts, Trevor S.;  Monibas, Rafael Mayoral;  Liu, Jinqi;  Li, Ying;  Wang, Liping;  Wilkerson, Joseph L.;  Sweeney, C. Rufus;  Pereira, Renato Felipe;  Sumida, Doris Hissako;  Maschek, J. Alan;  Cox, James E.;  Kaddai, Vincent;  Lancaster, Graeme Iain;  Siddique, Monowarul Mobin;  Poss, Annelise;  Pearson, Mackenzie;  Satapati, Santhosh;  Zhou, Heather;  McLaren, David G.;  Previs, Stephen F.;  Chen, Ying;  Qian, Ying;  Petrov, Aleksandr;  Wu, Margaret;  Shen, Xiaolan;  Yao, Jun;  Nunes, Christian N.;  Howard, Andrew D.;  Wang, Liangsu;  Erion, Mark D.;  Rutter, Jared;  Holland, William L.;  Kelley, David E.;  Summers, Scott A.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt object 期刊论文
SCIENCE, 2019, 364 (6441) : 649-+
作者:  Stern, S. A.;  Weaver, H. A.;  Spencer, J. R.;  Olkin, C. B.;  Gladstone, G. R.;  Grundy, W. M.;  Moore, J. M.;  Cruikshank, D. P.;  Elliott, H. A.;  McKinnon, W. B.;  Parker, J. Wm.;  Verbiscer, A. J.;  Young, L. A.;  Aguilar, D. A.;  Albers, J. M.;  Andert, T.;  Andrews, J. P.;  Bagenal, F.;  Banks, M. E.;  Bauer, B. A.;  Bauman, J. A.;  Bechtold, K. E.;  Beddingfield, C. B.;  Behrooz, N.;  Beisser, K. B.;  Benecchi, S. D.;  Bernardoni, E.;  Beyer, R. A.;  Bhaskaran, S.;  Bierson, C. J.;  Binzel, R. P.;  Birath, E. M.;  Bird, M. K.;  Boone, D. R.;  Bowman, A. F.;  Bray, V. J.;  Britt, D. T.;  Brown, L. E.;  Buckley, M. R.;  Buie, M. W.;  Buratti, B. J.;  Burke, L. M.;  Bushman, S. S.;  Careich, B.;  Chaikin, A. L.;  Chavez, C. L.;  Cheng, A. F.;  Colwell, E. J.;  Conard, S. J.;  Conner, M. P.;  Conrad, C. A.;  Cook, J. C.;  Cooper, S. B.;  Custodio, O. S.;  Ore, C. M. Dalle;  Deboy, C. C.;  Dharmavaram, P.;  Dhingra, R. D.;  Dunn, G. F.;  Earle, A. M.;  Egan, A. F.;  Eisig, J.;  El-Maarry, M. R.;  Engelbrecht, C.;  Enke, B. L.;  Ercol, C. J.;  Fattig, E. D.;  Ferrell, C. L.;  Finley, T. J.;  Firer, J.;  Fischetti, J.;  Folkner, W. M.;  Fosbury, M. N.;  Fountain, G. H.;  Freeze, J. M.;  Gabasova, L.;  Glaze, L. S.;  Green, J. L.;  Griffith, G. A.;  Guo, Y.;  Hahn, M.;  Hals, D. W.;  Hamilton, D. P.;  Hamilton, S. A.;  Hanley, J. J.;  Harch, A.;  Harmon, K. A.;  Hart, H. M.;  Hayes, J.;  Hersman, C. B.;  Hill, M. E.;  Hill, T. A.;  Hofgartner, J. D.;  Holdridge, M. E.;  Horanyi, M.;  Hosadurga, A.;  Howard, A. D.;  Howett, C. J. A.;  Jaskulek, S. E.;  Jennings, D. E.;  Jensen, J. R.;  Jones, M. R.;  Kang, H. K.;  Katz, D. J.;  Kaufmann, D. E.;  Kavelaars, J. J.;  Keane, J. T.;  Keleher, G. P.;  Kinczyk, M.;  Kochte, M. C.;  Kolmnann, P.;  Krimigis, S. M.;  Kruizinga, G. L.;  Kusnierkiewicz, D. Y.;  Lahr, M. S.;  Lauer, T. R.;  Lawrence, G. B.;  Lee, J. E.;  Lessac-Chenen, E. J.;  Linscott, I. R.;  Lisse, C. M.;  Lunsford, A. W.;  Mages, D. M.;  Mallder, V. A.;  Martin, N. P.;  May, B. H.;  McComas, D. J.;  MeNutt, R. L., Jr.;  Mehoke, D. S.;  Mehoke, T. S.;  Nelson, D. S.;  Nguyen, H. D.;  Nunez, J. I.;  Ocampo, A. C.;  Owen, W. M.;  Oxton, G. K.;  Parker, A. H.;  Patzold, M.;  Pelgrift, J. Y.;  Pelletier, F. J.;  Pineau, J. P.;  Piquette, M. R.;  Porter, S. B.;  Protopapa, S.;  Quirico, E.;  Redfern, J. A.;  Regiec, A. L.;  Reitsema, H. J.;  Reuter, D. C.;  Richardson, D. C.;  Riedel, J. E.;  Ritterbush, M. A.;  Robbins, S. J.;  Rodgers, D. J.;  Rogers, G. D.;  Rose, D. M.;  Rosendal, P. E.;  Runyon, K. D.;  Ryschkewitsch, M. G.;  Saina, M. M.;  Salinas, M. J.;  Schenk, P. M.;  Scherrer, J. R.;  Schlei, W. R.;  Schmitt, B.;  Schultz, D. J.;  Schurr, D. C.;  Scipioni, F.;  Sepan, R. L.;  Shelton, R. G.;  Showalter, M. R.;  Simon, M.;  Singer, K. N.;  Stahlheber, E. W.;  Stanbridge, D. R.;  Stansberry, J. A.;  Steffi, A. J.;  Strobel, D. F.;  Stothoff, M. M.;  Stryk, T.;  Stuart, J. M.;  Summers, M. E.;  Tapley, M. B.;  Taylor, A.;  Taylor, H. W.;  Tedford, R. M.;  Throop, H. B.;  Turner, L. S.;  Umurhan, O. M.;  Van Eck, J.;  Velez, D.;  Versteeg, M. H.;  Vincent, M. A.;  Webbert, R. W.;  Weidner, S. E.;  Ii, G. E. Weigle;  Wendel, J. R.;  White, O. L.;  Whittenburg, K. E.;  Williams, B. G.;  Williams, K. E.;  Williams, S. P.;  Wimters, H. L.;  Zangari, A. M.;  Zurbuchen, T. H.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Bilobate comet morphology and internal structure controlled by shear deformation 期刊论文
NATURE GEOSCIENCE, 2019, 12 (3) : 157-+
作者:  Matonti, C.;  Attree, N.;  Groussin, O.;  Jorda, L.;  Viseur, S.;  Hviid, S. F.;  Bouley, S.;  Nebouy, D.;  Auger, A-T;  Lamy, P. L.;  Sierks, H.;  Naletto, G.;  Rodrigo, R.;  Koschny, D.;  Davidsson, B.;  Barucci, M. A.;  Bertaux, J-L;  Bertini, I;  Bodewits, D.;  Cremonese, G.;  Da Deppo, V;  Debei, S.;  De Cecco, M.;  Deller, J.;  Fornasier, S.;  Fulle, M.;  Gutierrez, P. J.;  Guettler, C.;  Ip, W-H;  Keller, H. U.;  Lara, L. M.;  La Forgia, F.;  Lazzarin, M.;  Lucchetti, A.;  Lopez-Moreno, J. J.;  Marzari, F.;  Massironi, M.;  Mottola, S.;  Oklay, N.;  Pajola, M.;  Penasa, L.;  Preusker, F.;  Rickman, H.;  Scholten, F.;  Shi, X.;  Toth, I;  Tubiana, C.;  Vincent, J-B
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
Proglacial freshwaters are significant and previously unrecognized sinks of atmospheric CO2 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (36) : 17690-17695
作者:  St Pierre, Kyra A.;  St Louis, Vincent L.;  Schiff, Sherry L.;  Lehnherr, Igor;  Dainard, Paul G.;  Gardner, Alex S.;  Aukes, Pieter J. K.;  Sharp, Martin J.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
glacial meltwaters  carbon  biogeochemistry  freshwater  
Response to Comment on "An excess of massive stars in the local 30 Doradus starburst" 期刊论文
SCIENCE, 2018, 361 (6400)
作者:  Schneider, Fabian R. N.;  Sana, Hugues;  Evans, Christopher J.;  Bestenlehner, Joachim M.;  Castro, Norberto;  Fossati, Luca;  Graefener, Goetz;  Langer, Norbert;  Ramirez-Agudelo, Oscar H.;  Sabin-Sanjulian, Carolina;  Simon-Diaz, Sergio;  Tramper, Frank;  Crowther, Paul A.;  de Koter, Alexander;  de Mink, Selma E.;  Dufton, Philip L.;  Garcia, Miriam;  Gieles, Mark;  Henault-Brunet, Vincent;  Herrero, Artemio;  Izzard, Robert G.;  Kalari, Venu;  Lennon, Danny J.;  Maiz Apellaniz, Jesus;  Markova, Nevy;  Najarro, Francisco;  Podsiadlowski, Philipp;  Puls, Joachim;  Taylor, William D.;  van Loon, Jacco Th.;  Vink, Jorick S.;  Norman, Colin
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
A new data effort to inform career choices in biomedicine 期刊论文
SCIENCE, 2017, 358 (6369) : 1388-1389
作者:  Blank, Rebecca;  Daniels, Ronald J.;  Gilliland, Gary;  Gutmann, Amy;  Hawgood, Samuel;  Hrabowski, Freeman A.;  Pollack, Martha E.;  Price, Vincent;  Reif, L. Rafael;  Schlissel, Mark S.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27