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CAN THE WORLD MAKE ENOUGH CORONAVIRUS VACCINE? 期刊论文
NATURE, 2020, 580 (7805) : 578-580
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Liu, Mingjie;  Jiang, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


  
Very regular high-frequency pulsation modes in young intermediate-mass stars 期刊论文
NATURE, 2020, 581 (7807) : 147-+
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Jiang, Lei;  Liu, Mingjie
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Asteroseismology probes the internal structures of stars by using their natural pulsation frequencies(1). It relies on identifying sequences of pulsation modes that can be compared with theoretical models, which has been done successfully for many classes of pulsators, including low-mass solar-type stars(2), red giants(3), high-mass stars(4) and white dwarfs(5). However, a large group of pulsating stars of intermediate mass-the so-called delta Scuti stars-have rich pulsation spectra for which systematic mode identification has not hitherto been possible(6,7). This arises because only a seemingly random subset of possible modes are excited and because rapid rotation tends to spoil regular patterns(8-10). Here we report the detection of remarkably regular sequences of high-frequency pulsation modes in 60 intermediate-mass main-sequence stars, which enables definitive mode identification. The space motions of some of these stars indicate that they are members of known associations of young stars, as confirmed by modelling of their pulsation spectra.


The pulsation spectra of intermediate-mass stars (so-called delta Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.


  
REPLY TO ZHANG ET AL.: Using long-term all-available Landsat data to study water bodies over large areas represents a paradigm shift 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (12) : 6310-6311
作者:  Feng, Shuailong;  Liu, Shuguang;  Huang, Zhihong;  Jing, Lei;  Zhao, Meifang;  Peng, Xi;  Yan, Wende;  Wu, Yiping;  Lv, Yihe;  Smith, Andrew R.;  McDonald, Morag A.;  Patil, Sopan D.;  Sarkissian, Arbi J.;  Shi, Zhihua;  Xia, Jun;  Ogbodo, U. S.
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/13
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载:37/0  |  提交时间:2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tao, Chunhui;  Seyfried, W. E., Jr.;  Lowell, R. P.;  Liu, Yunlong;  Liang, Jin;  Guo, Zhikui;  Ding, Kang;  Zhang, Huatian;  Liu, Jia;  Qiu, Lei;  Egorov, Igor;  Liao, Shili;  Zhao, Minghui;  Zhou, Jianping;  Deng, Xianming;  Li, Huaiming;  Wang, Hanchuang;  Cai, Wei;  Zhang, Guoyin;  Zhou, Hongwei;  Lin, Jian;  Li, Wei
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/13
Nitrifier adaptation to low energy flux controls inventory of reduced nitrogen in the dark ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4823-4830
作者:  Zhang, Yao;  Qin, Wei;  Hou, Lei;  Zakem, Emily J.;  Wan, Xianhui;  Zhao, Zihao;  Liu, Li;  Hunt, Kristopher A.;  Jiao, Nianzhi;  Kao, Shuh-Ji;  Tang, Kai;  Xie, Xiabing;  Shen, Jiaming;  Li, Yufang;  Chen, Mingming;  Dai, Xiaofeng;  Liu, Chang;  Deng, Wenchao;  Dai, Minhan;  Ingalls, Anitra E.;  Stahl, David A.;  Herndl, Gerhard J.
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
nitrification  dark ocean  nitrogen flux  carbon fixation  homeostasis  
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tang, Bai-Lu;  Yang, Jie;  Chen, Xiu-Lan;  Wang, Peng;  Zhao, Hui-Lin;  Su, Hai-Nan;  Li, Chun-Yang;  Yu, Yang;  Zhong, Shuai;  Wang, Lei;  Lidbury, Ian;  Ding, Haitao;  Wang, Min;  McMinn, Andrew;  Zhang, Xi-Ying;  Chen, Yin;  Zhang, Yu-Zhong
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Dissecting primate early post-implantation development using long-term in vitro embryo culture 期刊论文
SCIENCE, 2019, 366 (6467) : 837-+
作者:  Niu, Yuyu;  Sun, Nianqin;  Li, Chang;  Lei, Ying;  Huang, Zhihao;  Wu, Jun;  Si, Chenyang;  Dai, Xi;  Liu, Chuanyu;  Wei, Jingkuan;  Liu, Longqi;  Feng, Su;  Kang, Yu;  Si, Wei;  Wang, Hong;  Zhang, E.;  Zhao, Lu;  Li, Ziwei;  Luo, Xi;  Cui, Guizhong;  Peng, Guangdun;  Belmonte, Juan Carlos Izpisua;  Ji, Weizhi;  Tan, Tao
收藏  |  浏览/下载:16/0  |  提交时间:2020/02/17
In vitro culture of cynomolgus monkey embryos beyond early gastrulation 期刊论文
SCIENCE, 2019, 366 (6467) : 836-+
作者:  Ma, Huaixiao;  Zhai, Jinglei;  Wan, Haifeng;  Jiang, Xiangxiang;  Wang, Xiaoxiao;  Wang, Lin;  Xiang, Yunlong;  He, Xiechao;  Zhao, Zhen-Ao;  Zhao, Bo;  Zheng, Ping;  Li, Lei;  Wang, Hongmei
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/17