GSTDTAP

浏览/检索结果: 共19条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Mutual promotion between aerosol particle liquid water and particulate nitrate enhancement leads to severe nitrate-dominated particulate matter pollution and low visibility 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (4) : 2161-2175
作者:  Wang, Yu;  Chen, Ying;  Wu, Zhijun;  Shang, Dongjie;  Bian, Yuxuan;  Du, Zhuofei;  Schmitt, Sebastian H.;  Su, Rong;  Gkatzelis, Georgios, I;  Schlag, Patrick;  Hohaus, Thorsten;  Voliotis, Aristeidis;  Lu, Keding;  Zen, Limin;  Zhao, Chunsheng;  Alfarra, M. Rami;  McFiggans, Gordon;  Wiedensohler, Alfred;  Kiendler-Scharr, Astrid;  Zhang, Yuanhang;  Hu, Min
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tang, Bai-Lu;  Yang, Jie;  Chen, Xiu-Lan;  Wang, Peng;  Zhao, Hui-Lin;  Su, Hai-Nan;  Li, Chun-Yang;  Yu, Yang;  Zhong, Shuai;  Wang, Lei;  Lidbury, Ian;  Ding, Haitao;  Wang, Min;  McMinn, Andrew;  Zhang, Xi-Ying;  Chen, Yin;  Zhang, Yu-Zhong
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
A review of experimental techniques for aerosol hygroscopicity studies 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (19) : 12631-12686
作者:  Tang, Mingjin;  Chan, Chak K.;  Li, Yong Jie;  Su, Hang;  Ma, Qingxin;  Wu, Zhijun;  Zhang, Guohua;  Wang, Zhe;  Ge, Maofa;  Hu, Min;  He, Hong;  Wang, Xinming
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
A missing component of Arctic warming: black carbon from gas flaring 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (9)
作者:  Cho, Mee-Hyun;  Park, Rokjin J.;  Yoon, Jinho;  Choi, Yonghan;  Jeong, Jaein I.;  Labzovskii, Lev;  Fu, Joshua S.;  Huang, Kan;  Jeong, Su-Jong;  Kim, Baek-Min
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
black carbon  gas flaring  sea-ice melting  Arctic warming  moisture transport  
A beta-induced vulnerability propagates via the brain's default mode network 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Pascoal, Tharick A.;  Mathotaarachchi, Sulantha;  Kang, Min Su;  Mohaddes, Sara;  Shin, Monica;  Park, Ah Yeon;  Parent, Maxime J.;  Benedet, Andrea L.;  Chamoun, Mira;  Therriault, Joseph;  Hwang, Heungsun;  Cuello, A. Claudio;  Misic, Bratislav;  Soucy, Jean-Paul;  Aston, John A. D.;  Gauthier, Serge;  Rosa-Neto, Pedro
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yang, Mi;  Li, Chang-Jun;  Sun, Xi;  Guo, Qi;  Xiao, Ye;  Su, Tian;  Tu, Man-Li;  Peng, Hui;  Lu, Qiong;  Liu, Qing;  He, Hong-Bo;  Jiang, Tie-Jian;  Lei, Min-Xiang;  Wan, Mei;  Cao, Xu;  Luo, Xiang-Hang
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Physicochemical uptake and release of volatile organic compounds by soil in coated-wall flow tube experiments with ambient air 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (4) : 2209-2232
作者:  Li, Guo;  Cheng, Yafang;  Kuhn, Uwe;  Xu, Rongjuan;  Yang, Yudong;  Meusel, Hannah;  Wang, Zhibin;  Ma, Nan;  Wu, Yusheng;  Li, Meng;  Williams, Jonathan;  Hoffmann, Thorsten;  Ammann, Markus;  Poechl, Ulrich;  Shao, Min;  Su, Hang
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Promotion of homology-directed DNA repair by polyamines 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Lee, Chih-Ying;  Su, Guan-Chin;  Huang, Wen-Yen;  Ko, Min-Yu;  Yeh, Hsin-Yi;  Chang, Geen-Dong;  Lin, Sung-Jan;  Chi, Peter
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27