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DOI | 10.1038/ncomms14086 |
Promotion of homology-directed DNA repair by polyamines | |
Lee, Chih-Ying1; Su, Guan-Chin1; Huang, Wen-Yen2; Ko, Min-Yu1; Yeh, Hsin-Yi1; Chang, Geen-Dong1; Lin, Sung-Jan2,3,4,5; Chi, Peter1,6 | |
2019-01-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Taiwan |
英文摘要 | Polyamines, often elevated in cancer cells, have been shown to promote cell growth and proliferation. Whether polyamines regulate other cell functions remains unclear. Here, we explore whether and how polyamines affect genome integrity. When DNA double-strand break (DSB) is induced in hair follicles by ionizing radiation, reduction of cellular polyamines augments dystrophic changes with delayed regeneration. Mechanistically, polyamines facilitate homologous recombination-mediated DSB repair without affecting repair via non-homologous DNA end-joining and single-strand DNA annealing. Biochemical reconstitution and functional analyses demonstrate that polyamines enhance the DNA strand exchange activity of RAD51 recombinase. The effect of polyamines on RAD51 stems from their ability to enhance the capture of homologous duplex DNA and synaptic complex formation by the RAD51-ssDNA nucleoprotein filament. Our work demonstrates a novel function of polyamines in the maintenance of genome integrity via homology-directed DNA repair. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455102900004 |
WOS关键词 | STRAND EXCHANGE ; ATP HYDROLYSIS ; RAD51 ; RECOMBINATION ; RECA ; CHEMOTHERAPY ; AGGREGATION ; INHIBITION ; MODULATION ; SINGLE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203190 |
专题 | 资源环境科学 |
作者单位 | 1.Natl Taiwan Univ, Inst Biochem Sci, Taipei 10617, Taiwan; 2.Natl Taiwan Univ, Dept Biomed Engn, Taipei 10617, Taiwan; 3.Natl Taiwan Univ Hosp, Dept Dermatol, Taipei 100, Taiwan; 4.Natl Taiwan Univ, Coll Med, Dept Dermatol, Taipei 10051, Taiwan; 5.Natl Taiwan Univ, Ctr Dev Biol & Regenerat Med, Taipei 10617, Taiwan; 6.Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan |
推荐引用方式 GB/T 7714 | Lee, Chih-Ying,Su, Guan-Chin,Huang, Wen-Yen,et al. Promotion of homology-directed DNA repair by polyamines[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Lee, Chih-Ying.,Su, Guan-Chin.,Huang, Wen-Yen.,Ko, Min-Yu.,Yeh, Hsin-Yi.,...&Chi, Peter.(2019).Promotion of homology-directed DNA repair by polyamines.NATURE COMMUNICATIONS,10. |
MLA | Lee, Chih-Ying,et al."Promotion of homology-directed DNA repair by polyamines".NATURE COMMUNICATIONS 10(2019). |
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