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DOI | 10.1038/s41467-019-09591-2 |
MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity | |
Yang, Mi1,2; Li, Chang-Jun1,2; Sun, Xi1,3; Guo, Qi1,4; Xiao, Ye1; Su, Tian1; Tu, Man-Li1,2; Peng, Hui1,3; Lu, Qiong1; Liu, Qing5; He, Hong-Bo5; Jiang, Tie-Jian1; Lei, Min-Xiang1; Wan, Mei2; Cao, Xu2; Luo, Xiang-Hang1 | |
2019-04-29 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31(hi)Emcn(hi) vessels decrease during ageing. Here we show that expression of the miR-497 similar to 195 cluster is high in CD31(hi)Emcn(hi) endothelium but gradually decreases during ageing. Mice with depletion of miR-497 similar to 195 in endothelial cells show fewer CD31(hi)Emcn(hi) vessels and lower bone mass. Conversely, transgenic overexpression of miR-497 similar to 195 in murine endothelium alleviates age-related reduction of type CD31(hi)Emcn(hi) vessels and bone loss. miR-497 similar to 195 cluster maintains the endothelial Notch activity and HIF-1a stability via targeting F-box and WD-40 domain protein (Fbxw7) and Prolyl 4-hydroxylase possessing a transmembrane domain (P4HTM) respectively. Notably, endothelialium-specific activation of miR-195 by intravenous injection of aptamer-agomiR-195 stimulates CD31(hi)Emcn(hi) vessel and bone formation in aged mice. Together, our study indicates that miR-497 similar to 195 regulates angiogenesis coupled with osteogenesis and may represent a potential therapeutic target for age-related osteoporosis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000404974500001 |
WOS关键词 | MESENCHYMAL STEM-CELLS ; HEPATOCELLULAR-CARCINOMA ; SUPPRESSES ANGIOGENESIS ; ANGIOCRINE FACTORS ; RNA INTERFERENCE ; BONE ; DIFFERENTIATION ; MICRORNAS ; TISSUE ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204342 |
专题 | 资源环境科学 |
作者单位 | 1.Cent S Univ, Xiangya Hosp, Endocrinol Res Ctr, Dept Endocrinol, Changsha 410008, Hunan, Peoples R China; 2.Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA; 3.Cent S Univ, Xiangya Hosp 2, Dept Endocrinol, Changsha 410011, Hunan, Peoples R China; 4.Aging & Regenerat Med Hunan Prov, Key Lab Organ Injury, Changsha 410008, Hunan, Peoples R China; 5.Cent S Univ, Xiangya Hosp, Dept Orthoped Surg, Changsha 410008, Hunan, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Mi,Li, Chang-Jun,Sun, Xi,et al. MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Yang, Mi.,Li, Chang-Jun.,Sun, Xi.,Guo, Qi.,Xiao, Ye.,...&Luo, Xiang-Hang.(2019).MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity.NATURE COMMUNICATIONS,8. |
MLA | Yang, Mi,et al."MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity".NATURE COMMUNICATIONS 8(2019). |
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