GSTDTAP  > 资源环境科学
DOI10.1038/s41467-019-09591-2
MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity
Yang, Mi1,2; Li, Chang-Jun1,2; Sun, Xi1,3; Guo, Qi1,4; Xiao, Ye1; Su, Tian1; Tu, Man-Li1,2; Peng, Hui1,3; Lu, Qiong1; Liu, Qing5; He, Hong-Bo5; Jiang, Tie-Jian1; Lei, Min-Xiang1; Wan, Mei2; Cao, Xu2; Luo, Xiang-Hang1
2019-04-29
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2017
卷号8
文章类型Article
语种英语
国家Peoples R China; USA
英文摘要

A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31(hi)Emcn(hi) vessels decrease during ageing. Here we show that expression of the miR-497 similar to 195 cluster is high in CD31(hi)Emcn(hi) endothelium but gradually decreases during ageing. Mice with depletion of miR-497 similar to 195 in endothelial cells show fewer CD31(hi)Emcn(hi) vessels and lower bone mass. Conversely, transgenic overexpression of miR-497 similar to 195 in murine endothelium alleviates age-related reduction of type CD31(hi)Emcn(hi) vessels and bone loss. miR-497 similar to 195 cluster maintains the endothelial Notch activity and HIF-1a stability via targeting F-box and WD-40 domain protein (Fbxw7) and Prolyl 4-hydroxylase possessing a transmembrane domain (P4HTM) respectively. Notably, endothelialium-specific activation of miR-195 by intravenous injection of aptamer-agomiR-195 stimulates CD31(hi)Emcn(hi) vessel and bone formation in aged mice. Together, our study indicates that miR-497 similar to 195 regulates angiogenesis coupled with osteogenesis and may represent a potential therapeutic target for age-related osteoporosis.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000404974500001
WOS关键词MESENCHYMAL STEM-CELLS ; HEPATOCELLULAR-CARCINOMA ; SUPPRESSES ANGIOGENESIS ; ANGIOCRINE FACTORS ; RNA INTERFERENCE ; BONE ; DIFFERENTIATION ; MICRORNAS ; TISSUE ; IDENTIFICATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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引用统计
被引频次:184[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/204342
专题资源环境科学
作者单位1.Cent S Univ, Xiangya Hosp, Endocrinol Res Ctr, Dept Endocrinol, Changsha 410008, Hunan, Peoples R China;
2.Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA;
3.Cent S Univ, Xiangya Hosp 2, Dept Endocrinol, Changsha 410011, Hunan, Peoples R China;
4.Aging & Regenerat Med Hunan Prov, Key Lab Organ Injury, Changsha 410008, Hunan, Peoples R China;
5.Cent S Univ, Xiangya Hosp, Dept Orthoped Surg, Changsha 410008, Hunan, Peoples R China
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GB/T 7714
Yang, Mi,Li, Chang-Jun,Sun, Xi,et al. MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity[J]. NATURE COMMUNICATIONS,2019,8.
APA Yang, Mi.,Li, Chang-Jun.,Sun, Xi.,Guo, Qi.,Xiao, Ye.,...&Luo, Xiang-Hang.(2019).MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity.NATURE COMMUNICATIONS,8.
MLA Yang, Mi,et al."MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity".NATURE COMMUNICATIONS 8(2019).
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