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Differentiation Between Nitrate Aerosol Formation Pathways in a Southeast Chinese City by Dual Isotope and Modeling Studies 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Xiao, Hong-Wei;  Zhu, Ren-Guo;  Pan, Yuan-Yuan;  Guo, Wei;  Zheng, Neng-Jian;  Liu, Yong-Hui;  Liu, Cheng;  Zhang, Zhong-Yi;  Wu, Jing-Feng;  Kang, Chang-An;  Luo, Li;  Xiao, Hua-Yun
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/18
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
Nagaoka ferromagnetism observed in a quantum dot plaquette 期刊论文
NATURE, 2020, 579 (7800) : 528-533
作者:  Yu, Yong;  Ma, Fei;  Luo, Xi-Yu;  Jing, Bo;  Sun, Peng-Fei;  Fang, Ren-Zhou;  Yang, Chao-Wei;  Liu, Hui;  Zheng, Ming-Yang;  Xie, Xiu-Ping;  Zhang, Wei-Jun;  You, Li-Xing;  Wang, Zhen;  Chen, Teng-Yun;  Zhang, Qiang;  Bao, Xiao-Hui;  Pan, Jian-Wei
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

A quantum dot device designed to host four electrons is used to demonstrate Nagaoka ferromagnetism-a model of itinerant magnetism that has so far been limited to theoretical investigation.


Engineered, highly controllable quantum systems are promising simulators of emergent physics beyond the simulation capabilities of classical computers(1). An important problem in many-body physics is itinerant magnetism, which originates purely from long-range interactions of free electrons and whose existence in real systems has been debated for decades(2,3). Here we use a quantum simulator consisting of a four-electron-site square plaquette of quantum dots(4) to demonstrate Nagaoka ferromagnetism(5). This form of itinerant magnetism has been rigorously studied theoretically(6-9) but has remained unattainable in experiments. We load the plaquette with three electrons and demonstrate the predicted emergence of spontaneous ferromagnetic correlations through pairwise measurements of spin. We find that the ferromagnetic ground state is remarkably robust to engineered disorder in the on-site potentials and we can induce a transition to the low-spin state by changing the plaquette topology to an open chain. This demonstration of Nagaoka ferromagnetism highlights that quantum simulators can be used to study physical phenomena that have not yet been observed in any experimental system. The work also constitutes an important step towards large-scale quantum dot simulators of correlated electron systems.


  
The Amplified Arctic Warming in the Recent Decades may Have Been Overestimated by CMIP5 Models 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (22) : 13338-13345
作者:  Huang, Jianbin;  Ou, Tinghai;  Chen, Deliang;  Luo, Yong;  Zhao, Zongci
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/17
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Future projection of summer surface air temperature trend over central India: Role of external forcing and internal variability 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Nath, Reshmita;  Luo, Yong;  Chen, Wen
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
external forcings  future projection  natural variability  SAT  summer  
Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Xing, Rui;  Zhou, Yong;  Yu, Jun;  Yu, Yingyan;  Nie, Yongzhan;  Luo, Wen;  Yang, Chao;  Xiong, Teng;  Wu, William K. K.;  Li, Zhongwu;  Bing, Yang;  Lin, Shuye;  Zhang, Yaping;  Hu, Yingqi;  Li, Lin;  Han, Lijuan;  Yang, Chen;  Huang, Shaogang;  Huang, Suiping;  Zhou, Rui;  Li, Jing;  Wu, Kaichun;  Fan, Daiming;  Tang, Guangbo;  Dou, Jianhua;  Zhu, Zhenggang;  Ji, Jiafu;  Fang, Xiaodong;  Lu, Youyong
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Contribution of atmospheric moisture transport to winter Arctic warming 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (5) : 2697-2710
作者:  Hao, Mingju;  Luo, Yong;  Lin, Yanluan;  Zhao, Zongci;  Wang, Lei;  Huang, Jianbin
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
Arctic  atmospheric moisture content  atmospheric moisture transport  Polar-WRF  surface air temperature  surface radiation balance  water cycle  
Underestimated ecosystem carbon turnover time and sequestration under the steady state assumption: A perspective from long-term data assimilation 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (3) : 938-953
作者:  Ge, Rong;  He, Honglin;  Ren, Xiaoli;  Zhang, Li;  Yu, Guirui;  Smallman, T. Luke;  Zhou, Tao;  Yu, Shi-Yong;  Luo, Yiqi;  Xie, Zongqiang;  Wang, Silong;  Wang, Huimin;  Zhou, Guoyi;  Zhang, Qibin;  Wang, Anzhi;  Fan, Zexin;  Zhang, Yiping;  Shen, Weijun;  Yin, Huajun;  Lin, Luxiang
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
carbon sequestration  climate sensitivity  non-steady state  steady state  turnover time  
Colossal grain growth yields single-crystal metal foils by contact-free annealing 期刊论文
SCIENCE, 2018, 362 (6418) : 1021-+
作者:  Jin, Sunghwan;  Huang, Ming;  Kwon, Youngwoo;  Zhang, Leining;  Li, Bao-Wen;  Oh, Sangjun;  Dong, Jichen;  Luo, Da;  Biswal, Mandakini;  Cunning, Benjamin V.;  Bakharev, Pavel V.;  Moon, Inyong;  Yoo, Won Jong;  Camacho-Mojica, Dulce C.;  Kim, Yong-Jin;  Lee, Sun Hwa;  Wang, Bin;  Seong, Won Kyung;  Saxena, Manav;  Ding, Feng;  Shin, Hyung-Joon;  Ruoff, Rodney S.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27