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DOI | 10.1038/s41467-017-01839-z |
Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer | |
Xing, Rui1; Zhou, Yong1; Yu, Jun2,3; Yu, Yingyan4; Nie, Yongzhan5; Luo, Wen1; Yang, Chao1; Xiong, Teng1; Wu, William K. K.2,3; Li, Zhongwu1; Bing, Yang1; Lin, Shuye1; Zhang, Yaping1; Hu, Yingqi1; Li, Lin6; Han, Lijuan7; Yang, Chen7; Huang, Shaogang7; Huang, Suiping7; Zhou, Rui8; Li, Jing8; Wu, Kaichun5; Fan, Daiming5; Tang, Guangbo5; Dou, Jianhua5; Zhu, Zhenggang4; Ji, Jiafu1; Fang, Xiaodong7; Lu, Youyong1,9 | |
2019-05-02 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which lead to high-level amplification of oncogenes. We find varying proportion of tandem-duplications (TDs) among individuals and identify 24 TD hotspots involving well-established cancer genes such as CCND1, ERBB2 and MYC. Specifically, we nominate a novel hotspot involving the super-enhancer of ZFP36L2 presents in approximately 10% GCs from different cohorts, the oncogenic role of which is further confirmed by experimental data. In addition, our data reveal a mutational signature, specifically occurring in noncoding region, significantly enriched in tumors with cadherin 1 mutations, and associated with poor prognoses. Collectively, our data suggest that TDs might serve as an important mechanism for cancer gene activation and provide a novel signature for stratification. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466458800014 |
WOS关键词 | SUPER-ENHANCERS ; MOLECULAR CHARACTERIZATION ; IDENTIFICATION ; INSTABILITY ; FRAMEWORK ; SUBTYPES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203541 |
专题 | 资源环境科学 |
作者单位 | 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Lab Mol Oncol, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China; 2.CUHK Shenzhen Res Inst, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Inst Digest Dis, Shenzhen 518000, Peoples R China; 3.CUHK Shenzhen Res Inst, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Dept Med & Therapeut, Shenzhen 518000, Peoples R China; 4.Shanghai Jiao Tong Univ, Rui Jin Hosp, Dept Surg, Sch Med, Shanghai 200025, Peoples R China; 5.Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Shanxi, Peoples R China; 6.Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Clin Ctr Endocrine & Metab Dis, Shanghai Key Lab Endocrine Tumours,Sch Med, Shanghai 200025, Peoples R China; 7.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China; 8.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Hubei, Peoples R China; 9.Beijing Hosp, Dept Med Oncol, Beijing 100730, Peoples R China |
推荐引用方式 GB/T 7714 | Xing, Rui,Zhou, Yong,Yu, Jun,et al. Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Xing, Rui.,Zhou, Yong.,Yu, Jun.,Yu, Yingyan.,Nie, Yongzhan.,...&Lu, Youyong.(2019).Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer.NATURE COMMUNICATIONS,10. |
MLA | Xing, Rui,et al."Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer".NATURE COMMUNICATIONS 10(2019). |
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