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Effects of single- and double-moment microphysics schemes on the intensity of super typhoon Sarika (2016) 期刊论文
ATMOSPHERIC RESEARCH, 2020, 238
作者:  Li, Jiangnan;  Ding, Chenghui;  Li, Fangzhou;  Chen, Youlong
收藏  |  浏览/下载：7/0  |  提交时间：2020/08/18
Tropical cyclone  Single moment microphysics  Double moment microphysics  Intensity  
Biomass-burning-induced surface darkening and its impact on regional meteorology in eastern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 6177-6191
作者:  Tang, Rong;  Huang, Xin;  Zhou, Derong;  Ding, Aijun
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/01
Significant production of ClNO2 and possible source of Cl-2 from N2O5 uptake at a suburban site in eastern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 6147-6158
作者:  Xia, Men;  Peng, Xiang;  Wang, Weihao;  Yu, Chuan;  Sun, Peng;  Li, Yuanyuan;  Liu, Yuliang;  Xu, Zhengning;  Wang, Zhe;  Xu, Zheng;  Nie, Wei;  Ding, Aijun;  Wang, Tao
收藏  |  浏览/下载：16/0  |  提交时间：2020/06/01
Amplified transboundary transport of haze by aerosol-boundary layer interaction in China 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 428-+
作者:  Huang, Xin;  Ding, Aijun;  Wang, Zilin;  Ding, Ke;  Gao, Jian;  Chai, Fahe;  Fu, Congbin
收藏  |  浏览/下载：8/0  |  提交时间：2020/06/01
A preliminary study on wind tunnel simulations of the explosive growth and dissipation of fine particulate matter in ambient air 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Xu, Jingxin;  Zhu, Fahua;  Wang, Sheng;  Zhao, Xiuyong;  Zhang, Ming;  Ge, Xinlei;  Wang, Junfeng;  Tian, Wenxin;  Wang, Liwen;  Yang, Liu;  Ding, Li;  Lu, Xiaobo;  Chen, Xinxin;  Zheng, Youfei;  Guo, Zhaobing
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/02
Wind tunnel  Fine particulate matter  Explosive growth  Dissipation  Relative humidity  Liquid water content  
Contrasting frontal and warm-sector heavy rainfalls over South China during the early-summer rainy season 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Wu, Naigeng;  Ding, Xi;  Wen, Zhiping;  Chen, Guixing;  Meng, Zhiyong;  Lin, Liangxun;  Min, Jinzhong
收藏  |  浏览/下载：7/0  |  提交时间：2020/07/02
Warm-sector heavy rainfall  Frontal heavy rainfall  Monsoon  Land-sea breeze  Diurnal variation  Early-summer rainy season  
Structural analysis and tectonic evolution of the western domain of the Eastern Kunlun Range, northwest Tibet 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1291-1315
作者:  Wu, Chen;  Liu, Changfeng;  Fan, Suoya;  Zuza, Andrew, V;  Ding, Lin;  Liu, Wencan;  Ye, Baoying;  Yang, Shijie;  Zhou, Zhiguang
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/02
Vertical characteristics of aerosol hygroscopicity and impacts on optical properties over the North China Plain during winter 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3931-3944
作者:  Liu, Quan;  Liu, Dantong;  Gao, Qian;  Tian, Ping;  Wang, Fei;  Zhao, Delong;  Bi, Kai;  Wu, Yangzhou;  Ding, Shuo;  Hu, Kang;  Zhang, Jiale;  Ding, Deping;  Zhao, Chunsheng
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/02
Editorial Expression of Concern: Quantized Majorana conductance 期刊论文
NATURE, 2020: 1-1
作者:  Ge, Peng;  Scholl, Dean;  Prokhorov, Nikolai S.;  Avaylon, Jaycob;  Shneider, Mikhail M.;  Browning, Christopher;  Buth, Sergey A.;  Plattner, Michel;  Chakraborty, Urmi;  Ding, Ke;  Leiman, Petr G.;  Miller, Jeff F.;  Zhou, Z. Hong
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03
Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.