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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Xing, Rui;  Zhou, Yong;  Yu, Jun;  Yu, Yingyan;  Nie, Yongzhan;  Luo, Wen;  Yang, Chao;  Xiong, Teng;  Wu, William K. K.;  Li, Zhongwu;  Bing, Yang;  Lin, Shuye;  Zhang, Yaping;  Hu, Yingqi;  Li, Lin;  Han, Lijuan;  Yang, Chen;  Huang, Shaogang;  Huang, Suiping;  Zhou, Rui;  Li, Jing;  Wu, Kaichun;  Fan, Daiming;  Tang, Guangbo;  Dou, Jianhua;  Zhu, Zhenggang;  Ji, Jiafu;  Fang, Xiaodong;  Lu, Youyong
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Single-cell multiomics sequencing and analyses of human colorectal cancer 期刊论文
SCIENCE, 2018, 362 (6418) : 1060-+
作者:  Bian, Shuhui;  Hou, Yu;  Zhou, Xin;  Li, Xianlong;  Yong, Jun;  Wang, Yicheng;  Wang, Wendong;  Yan, Jia;  Hu, Boqiang;  Guo, Hongshan;  Wang, Jilian;  Gao, Shuai;  Mao, Yunuo;  Dong, Ji;  Zhu, Ping;  Xiu, Dianrong;  Yan, Liying;  Wen, Lu;  Qiao, Jie;  Tang, Fuchou;  Fu, Wei
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Late spring soil moisture variation over the Tibetan Plateau and its influences on the plateau summer monsoon 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 (12) : 4597-4609
作者:  Zhou, Juan;  Wen, Jun;  Liu, Rong;  Wang, Xin;  Xie, Yan
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
mechanism  plateau monsoon  soil moisture  Tibetan Plateau  
Snow damage strongly reduces the strength of the carbon sink in a primary subtropical evergreen broadleaved forest 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2017, 12 (10)
作者:  Song, Qing-Hai;  Fei, Xue-Hai;  Zhang, Yi-Ping;  Sha, Li-Qing;  Wu, Chuan-Sheng;  Lu, Zhi-Yun;  Luo, Kang;  Zhou, Wen-Jun;  Liu, Yun-Tong;  Gao, Jin-Bo
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
snow damage  carbon balance  subtropical forest  southwest China  
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27