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Sensitivity Study of Weather Research and Forecasting Physical Schemes and Evaluation of Cool Coating Effects in Singapore by Weather Research and Forecasting Coupled with Urban Canopy Model Simulations 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Zhou, Mandi;  Long, Yongping;  Zhang, Xiaoqin;  Donthu, Eswara V. S. K. K.;  Ng, Bing Feng;  Wan, Man Pun
收藏  |  浏览/下载：13/0  |  提交时间：2020/08/18
Darwin's naturalization conundrum can be explained by spatial scale 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (20) : 10904-10910
作者:  Park, Daniel S.;  Feng, Xiao;  Maitner, Brian S.;  Ernst, Kacey C.;  Enquist, Brian J.
收藏  |  浏览/下载：16/0  |  提交时间：2020/05/13
biological invasions  competition  Darwin'  s naturalization hypothesis  environmental filtering  spatial resolution  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Plant community composition steers grassland vegetation via soil legacy effects 期刊论文
ECOLOGY LETTERS, 2020, 23 (6) : 973-982
作者:  Heinen, Robin;  Hannula, S. Emilia;  De Long, Jonathan R.;  Huberty, Martine;  Jongen, Renske;  Kielak, Anna;  Steinauer, Katja;  Zhu, Feng;  Bezemer, T. Martijn
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/13
Field experiment  grassland  pathogens  plant-soil feedback  soil bacteria  soil fungi  soil legacy effects  soil microbiome  
Leaf size of woody dicots predicts ecosystem primary productivity 期刊论文
ECOLOGY LETTERS, 2020, 23 (6) : 1003-1013
作者:  Li, Yaoqi;  Reich, Peter B.;  Schmid, Bernhard;  Shrestha, Nawal;  Feng, Xiao;  Lyu, Tong;  Maitner, Brian S.;  Xu, Xiaoting;  Li, Yichao;  Zou, Dongting;  Tan, Zheng-Hong;  Su, Xiangyan;  Tang, Zhiyao;  Guo, Qinghua;  Feng, Xiaojuan;  Enquist, Brian J.;  Wang, Zhiheng
收藏  |  浏览/下载：13/0  |  提交时间：2020/05/13
Annual evapotranspiration  China  community mean leaf size  large-scale eco-evolutionary patterns  leaf area index  North America  palaeo-primary productivity  plant functional traits  
REPLY TO ZHANG ET AL.: Using long-term all-available Landsat data to study water bodies over large areas represents a paradigm shift 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (12) : 6310-6311
作者:  Feng, Shuailong;  Liu, Shuguang;  Huang, Zhihong;  Jing, Lei;  Zhao, Meifang;  Peng, Xi;  Yan, Wende;  Wu, Yiping;  Lv, Yihe;  Smith, Andrew R.;  McDonald, Morag A.;  Patil, Sopan D.;  Sarkissian, Arbi J.;  Shi, Zhihua;  Xia, Jun;  Ogbodo, U. S.
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
Mechanisms and therapeutic implications of hypermutation in gliomas 期刊论文
NATURE, 2020, 580 (7804) : 517-+
作者:  Feng, Kaibo;  Quevedo, Raundi E.;  Kohrt, Jeffrey T.;  Oderinde, Martins S.;  Reilly, Usa;  White, M. Christina
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/03

A high tumour mutational burden (hypermutation) is observed in some gliomas(1-5)  however, the mechanisms by which hypermutation develops and whether it predicts the response to immunotherapy are poorly understood. Here we comprehensively analyse the molecular determinants of mutational burden and signatures in 10,294 gliomas. We delineate two main pathways to hypermutation: a de novo pathway associated with constitutional defects in DNA polymerase and mismatch repair (MMR) genes, and a more common post-treatment pathway, associated with acquired resistance driven by MMR defects in chemotherapy-sensitive gliomas that recur after treatment with the chemotherapy drug temozolomide. Experimentally, the mutational signature of post-treatment hypermutated gliomas was recapitulated by temozolomide-induced damage in cells with MMR deficiency. MMR-deficient gliomas were characterized by a lack of prominent T cell infiltrates, extensive intratumoral heterogeneity, poor patient survival and a low rate of response to PD-1 blockade. Moreover, although bulk analyses did not detect microsatellite instability in MMR-deficient gliomas, single-cell whole-genome sequencing analysis of post-treatment hypermutated glioma cells identified microsatellite mutations. These results show that chemotherapy can drive the acquisition of hypermutated populations without promoting a response to PD-1 blockade and supports the diagnostic use of mutational burden and signatures in cancer.


Temozolomide therapy seems to lead to mismatch repair deficiency and hypermutation in gliomas, but not to an increase in response to immunotherapy.


  
Asian inland wildfires driven by glacial-interglacial climate change 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (10) : 5184-5189
作者:  Han, Yongming;  An, Zhisheng;  Marlon, Jennifer R.;  Bradley, Raymond S.;  Zhan, Changlin;  Arimoto, Richard;  Sun, Youbin;  Zhou, Weijian;  Wu, Feng;  Wang, Qiyuan;  Burr, George S.;  Cao, Junji
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
biomass burning  Quaternary climate  carbon cycle  high-intensity fires  soluble iron  
Substantial Increases in Eastern Amazon and Cerrado Biomass Burning-Sourced Tropospheric Ozone 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Pope, Richard J.;  Arnold, Stephen R.;  Chipperfield, Martyn P.;  Reddington, Carly L. S.;  Butt, Edward W.;  Keslake, Tim D.;  Feng, Wuhu;  Latter, Barry G.;  Kerridge, Brian J.;  Siddans, Richard;  Rizzo, Luciana;  Artaxo, Paulo;  Sadiq, Mehliyar;  Tai, Amos P. K.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/02
African climate response to orbital and glacial forcing in 140,000-y simulation with implications for early modern human environments 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (5) : 2255-2264
作者:  Kutzbach, John E.;  Guan, Jian;  He, Feng;  Cohen, Andrew S.;  Orland, Ian J.;  Chen, Guangshan
收藏  |  浏览/下载：15/0  |  提交时间：2020/05/13
paleoclimate  Africa  climate modeling  glacial and orbital forcing  human dispersal