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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Bezawork-Geleta, Ayenachew;  Wen, He;  Dong, LanFeng;  Yan, Bing;  Vider, Jelena;  Boukalova, Stepana;  Krobova, Linda;  Vanova, Katerina;  Zobalova, Renata;  Sobol, Margarita;  Hozak, Pavel;  Novais, Silvia Magalhaes;  Caisova, Veronika;  Abaffy, Pavel;  Naraine, Ravindra;  Pang, Ying;  Zaw, Thiri;  Zhang, Ping;  Sindelka, Radek;  Kubista, Mikael;  Zuryn, Steven;  Molloy, Mark P.;  Berridge, Michael V.;  Pacak, Karel;  Rohlena, Jakub;  Park, Sunghyouk;  Neuzil, Jiri
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
Transport evidence of asymmetric spin-orbit coupling in few-layer superconducting 1T(d)-MoTe2 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Cui, Jian;  Li, Peiling;  Zhou, Jiadong;  He, Wen-Yu;  Huang, Xiangwei;  Yi, Jian;  Fan, Jie;  Ji, Zhongqing;  Jing, Xiunian;  Qu, Fanming;  Cheng, Zhi Gang;  Yang, Changli;  Lu, Li;  Suenaga, Kazu;  Liu, Junwei;  Law, Kam Tuen;  Lin, Junhao;  Liu, Zheng;  Liu, Guangtong
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Chen, Yuhan;  Huang, Qingyang;  Liu, Wen;  Zhu, Qiong;  Cui, Chun-Ping;  Xu, Liang;  Guo, Xing;  Wang, Ping;  Liu, Jingwen;  Dong, Guanglong;  Wei, Wenyi;  Liu, Cui Hua;  Feng, Zhichun;  He, Fuchu;  Zhang, Lingqiang
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Gli1 identifies osteogenic progenitors for bone formation and fracture repair 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Shi, Yu;  He, Guangxu;  Lee, Wen-Chih;  McKenzie, Jennifer A.;  Silva, Matthew J.;  Long, Fanxin
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Ground-to-satellite quantum teleportation 期刊论文
NATURE, 2017, 549 (7670) : 70-+
作者:  Ren, Ji-Gang;  Xu, Ping;  Yong, Hai-Lin;  Zhang, Liang;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Yang, Meng;  Li, Li;  Yang, Kui-Xing;  Han, Xuan;  Yao, Yong-Qiang;  Li, Ji;  Wu, Hai-Yan;  Wan, Song;  Liu, Lei;  Liu, Ding-Quan;  Kuang, Yao-Wu;  He, Zhi-Ping;  Shang, Peng;  Guo, Cheng;  Zheng, Ru-Hua;  Tian, Kai;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Lu, Chao-Yang;  Shu, Rong;  Chen, Yu-Ao;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy 期刊论文
SCIENCE, 2017, 357 (6350) : 507-511
作者:  Myers, Robert W.;  Guan, Hong-Ping;  Ehrhart, Juliann;  Petrov, Aleksandr;  Prahalada, Srinivasa;  Tozzo, Effie;  Yang, Xiaodong;  Kurtz, Marc M.;  Trujillo, Maria;  Trotter, Dinko Gonzalez;  Feng, Danqing;  Xu, Shiyao;  Eiermann, George;  Holahan, Marie A.;  Rubins, Daniel;  Conarello, Stacey;  Niu, Xiaoda;  Souza, Sandra C.;  Miller, Corin;  Liu, Jinqi;  Lu, Ku;  Feng, Wen;  Li, Ying;  Painter, Ronald E.;  Milligan, James A.;  He, Huaibing;  Liu, Franklin;  Ogawa, Aimie;  Wisniewski, Douglas;  Rohm, Rory J.;  Wang, Liyang;  Bunzel, Michelle;  Qian, Ying;  Zhu, Wei;  Wang, Hongwu;  Bennet, Bindu;  Scheuch, Lisa LaFranco;  Fernandez, Guillermo E.;  Li, Cai;  Klimas, Michael;  Zhou, Gaochao;  van Heek, Margaret;  Biftu, Tesfaye;  Weber, Ann;  Kelley, David E.;  Thornberry, Nancy;  Erion, Mark D.;  Kemp, Daniel M.;  Sebhat, Iyassu K.
收藏  |  浏览/下载:34/0  |  提交时间:2019/11/27
Regional variation in the temperature sensitivity of soil organic matter decomposition in China's forests and grasslands 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (8)
作者:  Liu, Yuan;  He, Nianpeng;  Zhu, Jianxing;  Xu, Li;  Yu, Guirui;  Niu, Shuli;  Sun, Xiaomin;  Wen, Xuefa
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
decomposition  forest  grassland  regional variation  soil organic matter  temperature sensitivity  
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27