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DOI | 10.1038/s41467-019-12338-8 |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints | |
Bezawork-Geleta, Ayenachew1,2; Wen, He3,4; Dong, LanFeng1; Yan, Bing1; Vider, Jelena1; Boukalova, Stepana5; Krobova, Linda5; Vanova, Katerina5; Zobalova, Renata5; Sobol, Margarita6; Hozak, Pavel6; Novais, Silvia Magalhaes5; Caisova, Veronika7,8; Abaffy, Pavel5; Naraine, Ravindra5; Pang, Ying7; Zaw, Thiri9; Zhang, Ping1; Sindelka, Radek5; Kubista, Mikael5,10; Zuryn, Steven2; Molloy, Mark P.9; Berridge, Michael V.11; Pacak, Karel7; Rohlena, Jakub5; Park, Sunghyouk4; Neuzil, Jiri1,5 | |
2019-09-25 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia; Peoples R China; South Korea; Czech Republic; USA; Sweden; New Zealand |
英文摘要 | Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CIIlow, serves as a checkpoint for metabolite biosynthesis under bioenergetic stress, with cells suppressing their energy utilization by modulating DNA synthesis and cell cycle progression. Depletion of CIIlow leads to an imbalance in energy utilization and metabolite synthesis, as evidenced by recovery of the de novo pyrimidine pathway and unlocking cell cycle arrest from the S-phase. In vitro experiments are further corroborated by analysis of paraganglioma tissues from patients with sporadic, SDHA and SDHB mutations. These findings suggest that CIIlow is a core complex inside mitochondria that provides homeostatic control of cellular metabolism depending on the availability of energy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000434379800018 |
WOS关键词 | ELECTRON-TRANSPORT CHAIN ; PYRUVATE-KINASE M2 ; MITOCHONDRIAL-DNA MUTATIONS ; NOVO PYRIMIDINE SYNTHESIS ; SUCCINATE-DEHYDROGENASE ; BREAST-CANCER ; CELL-PROLIFERATION ; PROTEIN-LEVELS ; GENE LISTS ; TCA CYCLE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204559 |
专题 | 资源环境科学 |
作者单位 | 1.Griffith Univ, Sch Med Sci, Southport, Qld 4222, Australia; 2.Univ Queensland, Queensland Brain Inst, Clem Jones Ctr Ageing Dementia Res, Brisbane, Qld 4072, Australia; 3.Shenzhen Univ, Sch Med, Dept Biochem & Mol Biol, Shenzhen 518060, Peoples R China; 4.Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; 5.Czech Acad Sci, Inst Biotechnol, Prague 25250, Czech Republic; 6.Czech Acad Sci, Inst Mol Genet, Prague 14220, Czech Republic; 7.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA; 8.Univ South Bohemia, Fac Sci, Ceske Budejovice 37005, Czech Republic; 9.Macquarie Univ, Australian Proteome Anal Facil, N Ryde, NSW 2109, Australia; 10.TATAA Bioctr, S-41103 Gothenburg, Sweden; 11.Malaghan Inst Med Res, Wellington 6242, New Zealand |
推荐引用方式 GB/T 7714 | Bezawork-Geleta, Ayenachew,Wen, He,Dong, LanFeng,et al. Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Bezawork-Geleta, Ayenachew.,Wen, He.,Dong, LanFeng.,Yan, Bing.,Vider, Jelena.,...&Neuzil, Jiri.(2019).Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.NATURE COMMUNICATIONS,9. |
MLA | Bezawork-Geleta, Ayenachew,et al."Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints".NATURE COMMUNICATIONS 9(2019). |
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