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Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Nitrifier adaptation to low energy flux controls inventory of reduced nitrogen in the dark ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4823-4830
作者:  Zhang, Yao;  Qin, Wei;  Hou, Lei;  Zakem, Emily J.;  Wan, Xianhui;  Zhao, Zihao;  Liu, Li;  Hunt, Kristopher A.;  Jiao, Nianzhi;  Kao, Shuh-Ji;  Tang, Kai;  Xie, Xiabing;  Shen, Jiaming;  Li, Yufang;  Chen, Mingming;  Dai, Xiaofeng;  Liu, Chang;  Deng, Wenchao;  Dai, Minhan;  Ingalls, Anitra E.;  Stahl, David A.;  Herndl, Gerhard J.
收藏  |  浏览/下载：14/0  |  提交时间：2020/05/13
nitrification  dark ocean  nitrogen flux  carbon fixation  homeostasis  
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Huang, Fengjie;  Zheng, Xiaojiao;  Ma, Xiaohui;  Jiang, Runqiu;  Zhou, Wangyi;  Zhou, Shuiping;  Zhang, Yunjing;  Lei, Sha;  Wang, Shouli;  Kuang, Junliang;  Han, Xiaolong;  Wei, Meilin;  You, Yijun;  Li, Mengci;  Li, Yitao;  Liang, Dandan;  Liu, Jiajian;  Chen, Tianlu;  Yan, Chao;  Wei, Runmin;  Rajani, Cynthia;  Shen, Chengxing;  Xie, Guoxiang;  Bian, Zhaoxiang;  Li, Houkai;  Zhao, Aihua;  Jia, Wei
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jiang, Xi;  Hu, Chao;  Ferchen, Kyle;  Nie, Ji;  Cui, Xiaolong;  Chen, Chih-Hong;  Cheng, Liting;  Zuo, Zhixiang;  Seibel, William;  He, Chunjiang;  Tang, Yixuan;  Skibbe, Jennifer R.;  Wunderlich, Mark;  Reinhold, William C.;  Dong, Lei;  Shen, Chao;  Arnovitz, Stephen;  Ulrich, Bryan;  Lu, Jiuwei;  Weng, Hengyou;  Su, Rui;  Huang, Huilin;  Wang, Yungui;  Li, Chenying;  Qin, Xi;  Mulloy, James;  Zheng, Yi;  Diao, Jiajie;  Jin, Jie;  Li, Chong;  Liu, Paul P.;  He, Chuan;  Chen, Yuan;  Chen, Jianjun
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Selective self-assembly of 2,3-diaminophenazine molecules on MoSe2 mirror twin boundaries 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  He, Xiaoyue;  Zhang, Lei;  Chua, Rebekah;  Wong, Ping Kwan Johnny;  Arramel, Arramel;  Feng, Yuan Ping;  Wang, Shi Jie;  Chi, Dongzhi;  Yang, Ming;  Huang, Yu Li;  Wee, Andrew Thye Shen
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
A universal state and its relaxation mechanisms of long-range interacting polygons 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Shen, Hongchuan;  Tong, Hua;  Tan, Peng;  Xu, Lei
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
Natural variation in CTB4a enhances rice adaptation to cold habitats 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Zhang, Zhanying;  Li, Jinjie;  Pan, Yinghua;  Li, Jilong;  Zhou, Lei;  Shi, Hongli;  Zeng, Yawen;  Guo, Haifeng;  Yang, Shuming;  Zheng, Weiwei;  Yu, Jianping;  Sun, Xingming;  Li, Gangling;  Ding, Yanglin;  Ma, Liang;  Shen, Shiquan;  Dai, Luyuan;  Zhang, Hongliang;  Yang, Shuhua;  Guo, Yan;  Li, Zichao
收藏  |  浏览/下载：18/0  |  提交时间：2019/11/27
Molecular basis for pore blockade of human Na+ channel Na(v)1.2 by the mu-conotoxin KIIIA 期刊论文
SCIENCE, 2019, 363 (6433) : 1309-+
作者:  Pan, Xiaojing;  Li, Zhangqiang;  Huang, Xiaoshuang;  Huang, Gaoxingyu;  Gao, Shuai;  Shen, Huaizong;  Liu, Lei;  Lei, Jianlin;  Yan, Nieng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins 期刊论文
SCIENCE, 2019, 363 (6433) : 1303-+
作者:  Shen, Huaizong;  Liu, Dongliang;  Wu, Kun;  Lei, Jianlin;  Yan, Nieng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Raman enhancement on ultra-clean graphene quantum dots produced by quasi-equilibrium plasma-enhanced chemical vapor deposition 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Liu, Donghua;  Chen, Xiaosong;  Hu, Yibin;  Sun, Tai;  Song, Zhibo;  Zheng, Yujie;  Cao, Yongbin;  Cai, Zhi;  Cao, Min;  Peng, Lan;  Huang, Yuli;  Du, Lei;  Yang, Wuli;  Chen, Gang;  Wei, Dapeng;  Shen, Andrew Thye;  Wei, Dacheng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27