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Temperature Inversion and Clouds Over the Arctic Ocean Observed by the 5th Chinese National Arctic Research Expedition 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Wang, Ding;  Guo, Jianping;  Chen, Aijun;  Bian, Lingen;  Ding, Minghu;  Liu, Lin;  Lv, Yanmin;  Li, Jian;  Guo, Xiaoran;  Han, Yi
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/18
cloud  temperature inversion  radiosonde  Arctic  
Role of Atmospheric Variability in Driving the "Warm-Arctic, Cold-Continent" Pattern Over the North America Sector and Sea Ice Variability Over the Chukchi-Bering Sea 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Guan, Weina;  Jiang, Xianan;  Ren, Xuejuan;  Chen, Gang;  Ding, Qinghua
收藏  |  浏览/下载:15/0  |  提交时间:2020/06/09
Arctic warming  surface air temperature  sea ice loss  atmospheric variability  large-scale circulation  
Amplified transboundary transport of haze by aerosol-boundary layer interaction in China 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 428-+
作者:  Huang, Xin;  Ding, Aijun;  Wang, Zilin;  Ding, Ke;  Gao, Jian;  Chai, Fahe;  Fu, Congbin
收藏  |  浏览/下载:8/0  |  提交时间:2020/06/01
Analysis of Location Errors of the US National Lightning Detection Network Using Lightning Strikes to Towers 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (9)
作者:  Zhu, Yanan;  Lyu, Weitao;  Cramer, John;  Rakov, Vladimir;  Bitzer, Phillip;  Ding, Ziqin
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Increasing Escape of Oxygen From Oceans Under Climate Change 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Li, Changyu;  Huang, Jianping;  Ding, Lei;  Liu, Xiaoyue;  Yu, Haipeng;  Huang, Jiping
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/13
Upper Mantle Deformation of the Terror Rift and Northern Transantarctic Mountains in Antarctica: Insight From P Wave Anisotropic Tomography 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Zhang, Heng;  Zhao, Dapeng;  Ju, Changhui;  Li, Yunyue Elita;  Li, Guohui;  Ding, Min;  Chen, Shuze;  Zhao, Junmeng
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Multiscale Variability of Meiyu and Its Prediction: A New Review 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (7)
作者:  Ding, Yihui;  Liang, Ping;  Liu, Yanju;  Zhang, Yaocun
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/02
Meiyu  multiscale variability  East Asian summer monsoon  Meiyu prediction  
Editorial Expression of Concern: Quantized Majorana conductance 期刊论文
NATURE, 2020: 1-1
作者:  Ge, Peng;  Scholl, Dean;  Prokhorov, Nikolai S.;  Avaylon, Jaycob;  Shneider, Mikhail M.;  Browning, Christopher;  Buth, Sergey A.;  Plattner, Michel;  Chakraborty, Urmi;  Ding, Ke;  Leiman, Petr G.;  Miller, Jeff F.;  Zhou, Z. Hong
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03
Relating CMIP5 Model Biases to Seasonal Forecast Skill in the Tropical Pacific 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Ding, Hui;  Newman, Matthew;  Alexander, Michael A.;  Wittenberg, Andrew T.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.