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Evaluation of land-atmosphere processes of the Polar WRF in the summertime Arctic tundra 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Kim, Jeongwon;  Lee, Junhong;  Hong, Je-Woo;  Hong, Jinkyu;  Koo, Ja-Ho;  Kim, Joo-Hong;  Yun, Juyeol;  Nam, Sungjin;  Jung, Ji Young;  Choi, Taejin;  Lee, Bang Yong
收藏  |  浏览/下载：14/0  |  提交时间：2020/08/18
Polar WRF  Arctic tundra  Land-atmosphere interaction  Surface energy balance  Soil moisture  Planetary boundary layer  
Subduction megathrust heterogeneity characterized from 3D seismic data 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Kirkpatrick, James D.;  Edwards, Joel H.;  Verdecchia, Alessandro;  Kluesner, Jared W.;  Harrington, Rebecca M.;  Silver, Eli A.
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
Lithological and structural controls on river profiles and networks in the northern Sierra Nevada (California, USA) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 655-667
作者:  Gabet, Emmanuel J.
收藏  |  浏览/下载：3/0  |  提交时间：2020/07/02
A very high-resolution assessment and modelling of urban air quality 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 625-647
作者:  Wolf, Tobias;  Pettersson, Lasse H.;  Esau, Igor
收藏  |  浏览/下载：5/0  |  提交时间：2020/07/02
Genomic basis for RNA alterations in cancer 期刊论文
NATURE, 2020, 578 (7793) : 129-+
作者:  Petitprez, Florent;  39;han
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Transcript alterations often result from somatic changes in cancer genomes(1). Various forms of RNA alterations have been described in cancer, including overexpression(2), altered splicing(3) and gene fusions(4)  however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(5). Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed '  bridged'  fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer.


  
Field-based investigation of fault architecture: A case study from the Lenghu fold-and-thrust belt, Qaidam Basin, NE Tibetan Plateau 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (1-2) : 389-408
作者:  Pei, Yangwen;  Paton, Douglas A.;  Knipe, Rob J.;  Lickorish, W. Henry;  Li, Anren;  Wu, Kongyou
收藏  |  浏览/下载：0/0  |  提交时间：2020/07/02
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1 期刊论文
SCIENCE, 2019, 366 (6472) : 1522-+
作者:  Le Nours, Jerome;  Gherardin, Nicholas A.;  Ramarathinam, Sri H.;  Awad, Wael;  Wiede, Florian;  Gully, Benjamin S.;  Khandokar, Yogesh;  Praveena, T.;  Wubben, Jacinta M.;  Sandow, Jarrod J.;  Webb, Andrew I.;  von Borstel, Anouk;  Rice, Michael T.;  Redmond, Samuel J.;  Seneviratna, Rebecca;  Sandoval-Romero, Maria L.;  Li, Shihan;  Souter, Michael N. T.;  Eckle, Sidonia B. G.;  Corbett, Alexandra J.;  Reid, Hugh H.;  Liu, Ligong;  Fairlie, David P.;  Giles, Edward M.;  Westall, Glen P.;  Tothill, Richard W.;  Davey, Martin S.;  Berry, Richard;  Tiganis, Tony;  McCluskey, James;  Pellicci, Daniel G.;  Purcell, Anthony W.;  Uldrich, Adam P.;  Godfrey, Dale I.;  Rossjohn, Jamie
收藏  |  浏览/下载：14/0  |  提交时间：2020/02/17
Time-resolved crystallography reveals allosteric communication aligned with molecular breathing 期刊论文
SCIENCE, 2019, 365 (6458) : 1167-+
作者:  Mehrabi, Pedram;  Schulz, Eike C.;  Dsouza, Raison;  Mueller-Werkmeister, Henrike M.;  Tellkamp, Friedjof;  Miller, R. J. Dwayne;  Pai, Emil F.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Molecular basis and biological function of variability in spatial genome organization 期刊论文
SCIENCE, 2019, 365 (6457) : 998-+
作者:  Finn, Elizabeth H.;  Misteli, Tom
收藏  |  浏览/下载：0/0  |  提交时间：2019/11/27
Remigration and leakage from continuous shale reservoirs: Insights from the Sichuan Basin and its periphery, China 期刊论文
AAPG BULLETIN, 2019, 103 (8) : 2009-2030
作者:  Ou, Chenghua;  Li, Chaochun;  Huang, Siyuan;  Sheng, James J.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27